Results 201 to 210 of about 159,690 (243)

Genomic instability in non-breast or ovarian malignancies of individuals with germline pathogenic variants in BRCA1/2. [PDF]

J Natl Cancer Inst
Elze L, van der Post RS, Vos JR, Mensenkamp AR, Pamidimarri Naga S, Hampstead JE, Vermeulen E, Oorsprong M, Hofste T, Simons M, Nagtegaal ID, Hoogerbrugge N, de Voer RM, Ligtenberg MJL.   +13 more
europepmc   +1 more source

Expression, Purification, and Microscopy‐Based Assays for Engineered Recombinant Tyrosinated, Detyrosinated, and Δ2 Human Tubulin

Cytoskeleton, EarlyView.
ABSTRACT Microtubules are noncovalent polymers assembled from α/β tubulin dimers. Their structure, dynamics and interaction with effectors are regulated through the expression of diverse tubulin isotypes and chemically diverse posttranslational modifications, also known as the “tubulin code.” Understanding the biophysical correlates between tubulin ...
Jiayi Chen, Agnieska Szyk, Antonina Roll‐Mecak   +2 more
wiley   +1 more source

Update on Recommendations for Cancer Screening and Surveillance in Children with Genomic Instability Disorders. [PDF]

Clin Cancer Res
Nakano Y, Kuiper RP, Nichols KE, Porter CC, Lesmana H, Meade J, Kratz CP, Godley LA, Maese LD, Achatz MI, Khincha PP, Savage SA, Doria AS, Greer MC, Chang VY, Wang LL, Plon SE, Walsh MF.   +17 more
europepmc   +1 more source

Improving Genotype Imputation in High‐Dimensional Pharmacogenomics Using Multiple Imputation: Evaluation with Machine Learning Approaches

Clinical Pharmacology &Therapeutics, EarlyView.
Multiple imputation is well‐established for handling missing data, yet its use in high‐dimensional genetic datasets remains limited. Using pharmacokinetic tuberculosis simulations and SNP data (1000 Genomes Project), we compared machine learning (ML) and traditional approaches (e.g., mean imputation and complete‐case analysis) for imputation and ...
Innocent G. Asiimwe, Tao You, Daniel F. Carr, Munir Pirmohamed, Geraint Davies, Andrea L. Jorgensen, on behalf of the UNITE4TB Consortium   +6 more
wiley   +1 more source

Tolerance of Oncogene-Induced Replication Stress: A Fuel for Genomic Instability. [PDF]

Cancers (Basel)
Igarashi T, Yano K, Endo S, Shiotani B.
europepmc   +1 more source

Genomic instability is associated with response to [¹⁷⁷Lu]Lu-PSMA-I&T radioligand therapy: an exploratory, preliminary liquid biopsy analysis. [PDF]

Eur J Nucl Med Mol Imaging
Kluge K, Haberl D, Haug A, Kenner L, Kramer G, Shariat S, Kumpf K, Hacker M.   +7 more
europepmc   +1 more source

Patterns of genomic instability in > 2000 patients with ovarian cancer across six clinical trials evaluating olaparib. [PDF]

Genome Med
Barnicle A, Ray-Coquard I, Rouleau E, Cadoo K, Simpkins F, Aghajanian C, Leary A, Poveda A, Lheureux S, Pujade-Lauraine E, You B, Ledermann J, Matulonis U, Gourley C, Timms KM, Lai Z, Hodgson DR, Elks CE, Dearden S, Egile C, Lao-Sirieix P, Harrington EA, Brown JS.   +22 more
europepmc   +1 more source

An agricultural triazole induces genomic instability and haploid cell formation in the human fungal pathogen Candida tropicalis. [PDF]

PLoS Biol
Hu T, Zheng Q, Cao C, Li S, Huang Y, Guan Z, Ji L, Bing J, Du H, Perry AM, Nobile CJ, Li B, Chu H, Huang G.   +13 more
europepmc   +1 more source

H3.1K27M-induced misregulation of the TSK/TONSL-H3.1 pathway causes genomic instability

Yuan W, Huang Y, LeBlanc C, Poulet A, Valsakumar D, van Wolfswinkel JC, Voigt P, Jacob Y.   +7 more
europepmc   +1 more source