Results 221 to 230 of about 291,376 (305)

A Single‐Enzyme Activated CRISPR‐Cas12a Nano System via Subtly Balanced dsDNA for Kinetic‐Gated UDG Detection and Spatiotemporal Cellular Imaging

Advanced Science, EarlyView.
Kinetic‐gated CRISPR–Cas12a activation enables single‐enzyme detection and spatiotemporal imaging of UDG ABSTRACT Uracil‐DNA glycosylase (UDG) is a key enzyme in base excision repair and an important biomarker for genomic stability and disease. In many reported sensing systems, uracil excision is coupled to signal generation through additional ...
Kejun Dong, Hao Hu, Haiyun Wang, Zijia Zheng, Shuangshuang Cheng, Wan Shu, Ruisi Liu, Xiaoyan Xin, Shiyi Huang, Dingchao Qian, Xianjin Xiao, Qiang Fu, Hongbo Wang   +12 more
wiley   +1 more source

<i>SuFu</i> somatic mutations are recognized as novel markers for genomic instability and tumor growth in lung adenocarcinoma. [PDF]

Transl Lung Cancer Res
Liu JH, Zhang T, Wang Y, Zhang MS, He J, Zhou XD.   +5 more
europepmc   +1 more source

Species Dependent Toxicity Comparison Outcome

Advanced Science, EarlyView.
By quantitatively assessing and comparing toxicity responses across different animal species and material compositions, our data reveal that toxicity rankings among different materials may be reversed across species. ABSTRACT Toxicity comparison plays a crucial role in material selection across diverse application fields.
Lian Xiao, Zhan Yu, Sihang Liu, Yuheng Liu, Chong Deng, Yugang Zhao, Yi Huang, Zhi‐Gang Zheng   +7 more
wiley   +1 more source

PUMA-induced apoptosis drives bone marrow failure and genomic instability in telomerase-deficient mice. [PDF]

Cell Death Differ
Molnar C, Rajak J, Weiss JM, Gonzalez-Menendez I, Andrieux G, Schreiber F, Kornemann EM, Wendeburg L, Göhring G, Strahm B, Beier F, Steinemann D, Börries M, Rudelius M, Quintanilla-Martinez L, Niemeyer CM, Niewisch MR, Labi V, Bohler S, Erlacher M.   +19 more
europepmc   +1 more source

Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination

Advanced Science, EarlyView.
Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song, Jingyang Liu, Xue Wang, Minpu Zhang, Changgang Sun   +4 more
wiley   +1 more source

Robust Assessment of Homologous Recombination Deficiency Genomic Instability by OncoScan Microarrays. [PDF]

J Mol Diagn
Lara Gutierrez A, Halbwedl I, Sauer S, Regitnig P, Petru E, Seeböck R, Schubert S, Peternell C, Bodó K, Prein K, Kashofer K.   +10 more
europepmc   +1 more source

Cell Cycle‐Specific Regulation of Centrosome Clustering Dynamics in Cancer Cells by the Multifunctional Kinesin HSET

Advanced Science, EarlyView.
CDK5RAP2 associates with the kinesin HSET and forms co‐condensates. HSET motors drive the directional transport of CDK5RAP2 condensates toward microtubule minus ends. During mitosis, HSET self‐assembly further stabilizes clustered centrosomes, thereby enabling pseudo‐bipolar spindle formation in cancer cells with supernumerary centrosomes. Upon mitotic
Po‐Pang Chen, Athira Saju, Chia‐Chou Wu, Tzu‐Han Weng, Su‐Yi Tsai, Tzu‐Lun Huang, Jia‐Ying Su, Chien‐Ling Lin, Yu‐Chun Lin, See‐Yeun Ting, Sheng‐hong Chen, Kuo‐Chiang Hsia   +11 more
wiley   +1 more source

Genomic instability and <i>CCNE1</i> amplification as emerging biomarkers for stratifying high-grade serous ovarian cancer. [PDF]

Front Oncol
Conca E, Lorenzini D, Minna E, Agnelli L, Duca M, Gentili M, Bodini B, Polignano M, Mantiero M, Damian S, Devecchi A, Dagrada G, Carminati R, Ardore A, Barbetta F, Da Chuna NB, Guerrizio A, Busico A, Capone I, Piccolo A, Tamborini E, Perrone F, Milione M, Paolini B, Vingiani A, Raspagliesi F, De Braud F, Pruneri G.   +27 more
europepmc   +1 more source

Evolutionary Assembly and Future Design of Gibberellin Signaling

Advanced Science, EarlyView.
ABSTRACT Gibberellin (GA) signaling is widely regarded as a canonical hormone‐controlled growth pathway, yet accumulating evidence suggests that it emerged through stepwise evolutionary assembly rather than as a pre‐formed regulatory system. Here, we revisit the origin and diversification of the GA pathway from an evolutionary perspective.
Weishu Fan, Xihan Chen, Dan Li, Xiuhua Gao, Xiangdong Fu   +4 more
wiley   +1 more source