Genomic instability - Open Access .click

Science
Germline structural variants are a risk factor for pediatric extracranial solid ...
Jayne Y, Hehir-Kwa, Geoff, Macintyre
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Genomic Instability and Cancer

Current Molecular Medicine, 2003
Tumorigenesis can be viewed as an imbalance between the mechanisms of cell-cycle control and mutation rates within the genes. Genomic instability is broadly classified into microsatellite instability (MIN) associated with mutator phenotype, and chromosome instability (CIN) recognized by gross chromosomal abnormalities.
George S, Charames, Bharati, Bapat
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Apoptosis and genomic instability

Nature Reviews Molecular Cell Biology, 2004
Genomic instability is intrinsically linked to significant alterations in apoptosis control. Chromosomal and microsatellite instability can cause the inactivation of pro-apoptotic pathways. In addition, the inhibition of apoptosis itself can be permissive for the survival and ongoing division of cells that have failed to repair DNA double-strand breaks,
Boris, Zhivotovsky, Guido, Kroemer
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Genomic instability in neoplasia

Seminars in Cell Biology, 1995
Recent studies have demonstrated novel alterations of microsatellite DNA in tumor tissue. The alterations, termed microsatellite instability or replication error phenotype, have now been observed in tumors from patients with hereditary nonpolyposis colorectal cancer (HNPCC), the Muir-Torre syndrome (MTS) and in an increasing number of sporadic tumors ...
R, Honchel, K C, Halling, S N, Thibodeau
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humans
animals
neoplasms

3. good health
dna damage
dna repair

mutation
dna replication
medicine