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Apoptosis and genomic instability
Nature Reviews Molecular Cell Biology, 2004Genomic instability is intrinsically linked to significant alterations in apoptosis control. Chromosomal and microsatellite instability can cause the inactivation of pro-apoptotic pathways. In addition, the inhibition of apoptosis itself can be permissive for the survival and ongoing division of cells that have failed to repair DNA double-strand breaks,
Boris, Zhivotovsky, Guido, Kroemer
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Genomic Instability and Epigenetic Changes during Aging
International Journal of Molecular Sciences, 2023 Aging is considered the deterioration of physiological functions along with an increased mortality rate. This scientific review focuses on the central importance of genomic instability during the aging process, encompassing a range of cellular and ...
Amparo Pascual-Ahuir +2 more
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Annual Review of Physiology, 2013
Genome instability has long been implicated as the main causal factor in aging. Somatic cells are continuously exposed to various sources of DNA damage, from reactive oxygen species to UV radiation to environmental mutagens. To cope with the tens of thousands of chemical lesions introduced into the genome of a typical cell each day, a complex network ...
Jan, Vijg, Yousin, Suh
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Genome instability has long been implicated as the main causal factor in aging. Somatic cells are continuously exposed to various sources of DNA damage, from reactive oxygen species to UV radiation to environmental mutagens. To cope with the tens of thousands of chemical lesions introduced into the genome of a typical cell each day, a complex network ...
Jan, Vijg, Yousin, Suh
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Annual Review of Genetics, 2013
Genomes are transmitted faithfully from dividing cells to their offspring. Changes that occur during DNA repair, chromosome duplication, and transmission or via recombination provide a natural source of genetic variation. They occur at low frequency because of the intrinsic variable nature of genomes, which we refer to as genome instability.
Andrés, Aguilera, Tatiana, García-Muse
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Genomes are transmitted faithfully from dividing cells to their offspring. Changes that occur during DNA repair, chromosome duplication, and transmission or via recombination provide a natural source of genetic variation. They occur at low frequency because of the intrinsic variable nature of genomes, which we refer to as genome instability.
Andrés, Aguilera, Tatiana, García-Muse
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Transcription-Associated Genome Instability
Chemical Reviews, 2013Peer ...
Gaillard, Hélène +2 more
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Science
Germline structural variants are a risk factor for pediatric extracranial solid ...
Jayne Y, Hehir-Kwa, Geoff, Macintyre
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Germline structural variants are a risk factor for pediatric extracranial solid ...
Jayne Y, Hehir-Kwa, Geoff, Macintyre
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Genome instability and oncogenesis
Molecular Biology, 2007Molecular alterations leading to genetic instability play a key role in tumor development. The basic reasons of genetic instability of tumor cells, i.e. up-regulation of intracellular level of endogenous mutagens, in particular reactive oxygen spesies (ROS); decreased fidelity of DNA replication and chromosome segregation in mitosis; defects in DNA ...
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Genomic instability and radiation
Journal of Radiological Protection, 2003Genomic instability is a hallmark of cancer cells, and is thought to be involved in the process of carcinogenesis. Indeed, a number of rare genetic disorders associated with a predisposition to cancer are characterised by genomic instability occurring in somatic cells.
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2018
Genome instability: methods and protocols. , Genome instability: methods and protocols.
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Genome instability: methods and protocols. , Genome instability: methods and protocols.
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Radiation-induced genomic instability
International Journal of Radiation Biology, 1998Purpose: This report reviews the data obtained in the author's laboratory over the past two decades, which support the hypothesis that radiation can induce a genome-wide process of instability in mammalian cells that is transmitted over many generations of cell replication leading to an enhanced frequency of genetic changes occurring among the progeny ...
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