Results 251 to 260 of about 184,862 (303)

Unraveling the nexus: Genomic instability and metabolism in cancer. [PDF]

Cell Rep
Gujar V, Li H, Paull TT, Neumann CA, Weyemi U.   +4 more
europepmc   +1 more source

Chronic Occupational Exposure to Chemical Mixtures Induces Genomic Instability in Paint Workers. [PDF]

Toxics
İritaş SB, Bacanlı MG, Taner G, Türksoy VA, Tutkun L, Yilmaz ÖH, Başaran AN.   +6 more
europepmc   +1 more source

Methylation aberrations and genomic instability synergistically drive the evolution of intrahepatic cholangiocarcinoma. [PDF]

Epigenomics
Li G, Bai Y, Tao F, Hu T, Wang T, Zeng Y, Sun D.   +6 more
europepmc   +1 more source

Lamin A/C loss promotes R-loop-mediated genomic instability and poor survival in small-cell lung cancer. [PDF]

Proc Natl Acad Sci U S A
Schultz CW, Saha S, Dhall A, Zhang Y, Desai P, Pongor LS, Scheiblin DA, Magidson V, Shuklah RP, Sebastian R, Vekariya UM, Ahmed S, Sun Y, Redon C, Kumar S, Krishnamurthy M, Dias HB, Aksenova V, Giordano E, Takahashi N, Nirula M, Arora M, Tabe C, Thomas MS, Kumar R, Arakawa Y, Jo U, Skorski T, Teicher BA, Shreshta R, Aladjem MI, Lockett S, Dasso M, Pommier Y, Sharma AK, Thomas A.   +35 more
europepmc   +1 more source

Single-Cell RNA Analysis of Murine Osteosarcoma Uncovers Skp2 Function in Metastasis, Genomic Instability, and Immune Activation and Reveals Additional Target Pathways. [PDF]

Cancer Res Commun
Ferrena A, Zhang R, Wang J, Wang J, Zheng XY, Göker B, Barotti G, Borjihan H, Chae SS, Lo Y, Zhao H, Schwartz EL, Offenbacher R, Loeb DM, Yang R, Sidoli S, Geller D, Zheng D, Hoang B.   +18 more
europepmc   +1 more source

Cancer histone mutations impact protein binding and DNA repair with possible links to genomic instability. [PDF]

Nucleic Acids Res
Espiritu D, Sheng Y, Peng Y, Ostroverkhova D, Li S, Landsman D, Aristizabal MJ, Panchenko AR.   +7 more
europepmc   +1 more source

Genomic instability — an evolving hallmark of cancer

Nature Reviews Molecular Cell Biology, 2010
Genomic instability is a characteristic of most cancers. In hereditary cancers, genomic instability results from mutations in DNA repair genes and drives cancer development, as predicted by the mutator hypothesis. In sporadic (non-hereditary) cancers the
Vassilis G Gorgoulis, Thanos D Halazonetis, Gorgoulis Vassilis G   +2 more
exaly   +3 more sources

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Combing the genome for genomic instability

Trends in Biotechnology, 2002
Genomic instability is one of the major features of cancer cells. The clinical phenotypes associated with several human diseases have been linked to recurrent DNA rearrangements and dysfunction of DNA replication processes that involve unstable genomic regions.
Sandrine, Caburet, Chiara, Conti, Aaron, Bensimon   +2 more
openaire   +2 more sources

Genomic Instability and Cancer

Current Molecular Medicine, 2003
Tumorigenesis can be viewed as an imbalance between the mechanisms of cell-cycle control and mutation rates within the genes. Genomic instability is broadly classified into microsatellite instability (MIN) associated with mutator phenotype, and chromosome instability (CIN) recognized by gross chromosomal abnormalities.
George S, Charames, Bharati, Bapat
openaire   +2 more sources

Genomic instability in neoplasia

Seminars in Cell Biology, 1995
Recent studies have demonstrated novel alterations of microsatellite DNA in tumor tissue. The alterations, termed microsatellite instability or replication error phenotype, have now been observed in tumors from patients with hereditary nonpolyposis colorectal cancer (HNPCC), the Muir-Torre syndrome (MTS) and in an increasing number of sporadic tumors ...
R, Honchel, K C, Halling, S N, Thibodeau
openaire   +2 more sources