Results 141 to 150 of about 333,629 (311)

Genomic prediction for rust resistance in pea

Frontiers in Plant Science
Genomic selection (GS) has become an indispensable tool in modern plant breeding, particularly for complex traits. This study aimed to assess the efficacy of GS in predicting rust (Uromyces pisi) resistance in pea (Pisum sativum), using a panel of 320 pea accessions and a set of 26,045 Silico-Diversity Arrays Technology (Silico-DArT) markers.
Osuna-Caballero, Salvador, Rubiales, Diego, Annicchiarico, Paolo, Nazzicari, Nelson, Rispail, Nicolas   +4 more
openaire   +4 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Modelling and Using Spatial Effects in Nationwide Historical Data Improve Genomic Prediction of Rice Heading Date in Japan

Rice
Genomic prediction is a promising strategy for enhancing crop breeding efficiency. Historical data of breeding and cultivation tests from geographically wide regions presumably contain rich information for training genomic prediction models.
Shoji Taniguchi, Takeshi Hayashi, Hiroshi Nakagawa, Kei Matsushita, Hiromi Kajiya-Kanegae, Jun-Ichi Yonemaru, Akitoshi Goto   +6 more
doaj   +1 more source

An investigation of machine learning methods applied to genomic prediction in yellow-feathered broilers

Poultry Science
Machine learning (ML) methods have rapidly developed in various theoretical and practical research areas, including predicting genomic breeding values for large livestock animals.
Bogong Liu, Huichao Liu, Junhao Tu, Jian Xiao, Jie Yang, Xi He, Haihan Zhang   +6 more
doaj   +1 more source

Assessment of Genomic Prediction for Sorghum Seed Parent Evaluation

, 2023
Genomic prediction has shown to be an effective tool for plant and animal breeders, allowing for prediction of phenotypes and breeding values. For crops that have vast acres planted in the United States, such as maize, soybean, and wheat, numerous ...
Kent, Mitchell Allen
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

Correction to: Predicting the accuracy of genomic predictions [PDF]

Genetics Selection Evolution, 2021
Jack C. M. Dekkers, Hailin Su, Jian Cheng   +2 more
openaire   +2 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source