Results 131 to 140 of about 333,629 (311)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Weighted Kernel Ridge Regression to Improve Genomic Prediction

Agriculture
Nonparametric models have recently been receiving increased attention due to their effectiveness in genomic prediction for complex traits. However, regular nonparametric models cannot effectively differentiate the relative importance of various SNPs ...
Chenguang Diao, Yue Zhuo, Ruihan Mao, Weining Li, Heng Du, Lei Zhou, Jianfeng Liu   +6 more
doaj   +1 more source

Genomic prediction script

, 2018
Perl wrapper script (forks to run multiple jobs) to run the genomic prediction option in gemma.
Gompert, Zach, Lucas, Lauren, Lauren Lucas (3288597), Chris Nice (5017265), Zach Gompert (3191738), Nice, Chris   +5 more
core   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Genomic Prediction from Multi-Environment Trials of Wheat Breeding

Genomic prediction relates a set of markers to variability in observed phenotypes of cultivars and allows for the prediction of phenotypes or breeding values of genotypes on unobserved individuals.
Gerard, G.S., Aguilar Rincón, V.H., Leonardo Crespo-Herrera, Crespo Herrera, L.A., Guillermo Sebastián Gerard, José Sergio Sandoval-Islas, Tarsicio Corona-Torres, Corona-Torres, T., Crossa, J., Paolo Vitale, Garcia Barrios, G., Serafín Cruz-Izquierdo, Guillermo García-Barrios, Cruz-Izquierdo, S., Rosa Angela Pacheco-Gil, Vitale, P., Sandoval-Islas, J.S., Víctor Heber Aguilar-Rincón, José Crossa, Pacheco Gil, R.A,   +19 more
core   +1 more source

GIPSy: Genomic island prediction software

, 2016
Soares SC, Geyik H, Ramos RTJ, et al. GIPSy: Genomic island prediction software. Journal of Biotechnology. 2016;232:2-11.Bacteria are highly diverse organisms that are able to adapt to a broad range of environments and hosts due to their high genomic ...
Soares, Siomar C, de Sá, Pablo H. C. G., Soares, Siomar C., Azevedo, Vasco, Baumbach, Jan, Ramos, Rommel T J, Barbosa, Eudes G. V., Figueiredo, Henrique C. P., Miyoshi, Anderson, Tauch, Andreas, Geyik, Hakan, Ramos, Rommel T. J., Barbosa, Eudes G V, Figueiredo, Henrique C P, Silva, Artur, de Sá, Pablo H C G   +15 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source