Results 121 to 130 of about 1,988,937 (263)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Domestic and Interbull information in the single step genomic evaluation of Holstein milk production

Czech Journal of Animal Science, 2014
Estimated breeding values and genomic enhanced breeding values for milk production of young genotyped Holstein bulls were predicted using a conventional animal model, ridge regression genomic prediction procedure, genomic best linear unbiased prediction,
J. Přibyl, J. Bauer, P. Pešek, J. Přibylová, L. Vostrý, L. Zavadilová   +5 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Optimizing clinico-genomic disease prediction across ancestries: a machine learning strategy with Pareto improvement

Genome Medicine
Background Accurate prediction of an individual’s predisposition to diseases is vital for preventive medicine and early intervention. Various statistical and machine learning models have been developed for disease prediction using clinico-genomic data ...
Yan Gao, Yan Cui
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Modeling copy number variation in the genomic prediction of maize hybrids

, 2019
Non-additive effects resulting from the actions of multiple loci may influence trait variation in single-cross hybrids. In addition, complementation of allelic variation could be a valuable contributor to hybrid genetic variation, especially when ...
Alves, F. C., Morosini, Júlia Silva, Massaine Bandeira e Sousa, Filipe Couto Alves, Morosini, J. S., Vidotti, Miriam Suzane, Fritsche-Neto, R., Júlia Silva Morosini, Granato, Ítalo Stefanine Correia, Granato, I. S. C., Danilo Hottis Lyra, Vidotti, M. S., Miriam Suzane Vidotti, Roberto Fritsche-Neto, Lyra, D. H., Giovanni Galli, Crossa, J., Fritsche-Neto, Roberto, Sousa, M. B., Ítalo Stefanine Correia Granato, Lyra, Danilo Hottis, Crossa, José, Galli, Giovanni, Alves, Filipe Couto, José Crossa, Galli, G., Bandeira e Sousa, Massaine   +26 more
core   +1 more source

Integrating Gene Expression Data into Single-Step Method (ssBLUP) Improves Genomic Prediction Accuracy for Complex Traits of Duroc × Erhualian F₂ Pig Population

Current Issues in Molecular Biology
The development of multi-omics has increased the likelihood of further improving genomic prediction (GP) of complex traits. Gene expression data can directly reflect the genotype effect, and thus, they are widely used for GP.
Fangjun Xu, Zhaoxuan Che, Jiakun Qiao, Pingping Han, Na Miao, Xiangyu Dai, Yuhua Fu, Xinyun Li, Mengjin Zhu   +8 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

(A)cross-breed Genomic Prediction [PDF]

, 2014
Genomic prediction holds the promise to use information of other populations to improve prediction accuracy. Thus far, empirical evaluations showed limited benefit of multi-breed compared to single reed genomic prediction. We compared prediction accuracy
Calus, M.P.L., Vereijken, A., Veerkamp, R.F., ten Napel, J., Napel, J., ten, Bastiaansen, J.W.M., Price, M.D., Windig, J.J., Huang, H., Wientjes, Y.C.J.   +9 more
core  

Triple categorical regression for genomic selection: application to cassava breeding

Scientia Agricola, 2019
: Genome-wide selection (GWS) is currently a technique of great importance in plant breeding, since it improves efficiency of genetic evaluations by increasing genetic gains.
Leísa Pires Lima, Camila Ferreira Azevedo, Marcos Deon Vilela de Resende, Fabyano Fonseca e Silva, José Marcelo Soriano Viana, Eder Jorge de Oliveira   +5 more
doaj   +1 more source