Results 101 to 110 of about 1,988,937 (263)
ShinyGPAS: interactive genomic prediction accuracy simulator based on deterministic formulas
Genetics Selection Evolution, 2017 Background Deterministic formulas for the accuracy of genomic predictions highlight the relationships among prediction accuracy and potential factors influencing prediction accuracy prior to performing computationally intensive cross-validation ...
Gota Morota
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Genomic distance under gene substitutions [PDF]
, 2011 Dias Vieira Braga M, Machado R, Ribeiro LC, Stoye J. Genomic distance under gene substitutions. BMC Bioinformatics. 2011;12(Suppl 9: Proc. of RECOMB-CG 2011): S8.Background: The distance between two genomes is often computed by comparing only the common
Stoye Jens +11 more
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Genomics and predictive medicine
The Siberian Journal of Clinical and Experimental Medicine, 2021 Progress in understanding of structural and functional human genome organization and deciphering primary DNA sequence in human cells allowed for hitherto unreachable new capabilities of medical genetics in identifying the causes and mechanisms of inherited and inborn pathology.
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Controlling population structure in the genomic prediction of tropical maize hybrids
, 2018 In tropical maize breeding programs where more than two heterotic groups are crossed, factors such as population structure (PS) can influence the achievement of reliable estimates of genomic breeding values (GEBVs) for complex traits.
Jianming Yu +26 more
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Signal Processing Methods for Genomic Sequence Analysis [PDF]
, 2007 Signal processing is the art of representing, transforming, analyzing, and manipulating signals. It deals with a wide range of signals, from speech and audio signals to images and video signals, and many others.
Yoon, Byung-Jun
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Computational methods for predicting genomic islands in microbial genomes
Computational and Structural Biotechnology Journal, 2016 Clusters of genes acquired by lateral gene transfer in microbial genomes, are broadly referred to as genomic islands (GIs). GIs often carry genes important for genome evolution and adaptation to niches, such as genes involved in pathogenesis and antibiotic resistance.
Lu, Bingxin, Leong, Hon Wai
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Global sequence features based translation initiation site prediction in human genomic sequences
Heliyon, 2020 Gene prediction has been increasingly important in genome annotation due to advancements in sequencing technology. Genome annotation further helps in determining the structure and function of these genes.
Neelam Goel +2 more
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