Results 91 to 100 of about 1,988,937 (263)

Ensemble approach combining multiple methods improves human transcription start site prediction [PDF]

, 2010
Dineen DG, Schroeder M, Higgins DG, Cunningham P. Ensemble approach combining multiple methods improves human transcription start site prediction. BMC Genomics.
Cunningham Pádraig, Higgins Desmond G, Desmond G Higgins, David G Dineen, Schröder Markus, Markus Schröder, Pádraig Cunningham, Cunningham, Padraig, Higgins, Desmond G., Dineen David G, Dineen, David G., Schroeder, Markus   +11 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Genomic Prediction of Piglet Responses to Infection with One or Two Porcine Reproductive and Respiratory Syndrome Virus Isolates [PDF]

, 2018
Genomic prediction of the pig’s response to the porcine reproductive and respiratory syndrome (PRRS) virus (PRRSV) would be a useful tool in the swine industry.
Tuggle, Christopher K., Rowland, Raymond R. R., Dekkers, Jack C. M., Plastow, Graham, Schroyen, Martine, Serao, Nick V. I., Lunney, Joan K., Hess, Andrew, Waide, Emily H.   +8 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Multi-omics-data-assisted genomic feature markers preselection improves the accuracy of genomic prediction

Journal of Animal Science and Biotechnology, 2020
Background Presently, multi-omics data (e.g., genomics, transcriptomics, proteomics, and metabolomics) are available to improve genomic predictors. Omics data not only offers new data layers for genomic prediction but also provides a bridge between ...
Shaopan Ye, Jiaqi Li, Zhe Zhang
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Impact of Phenotypic Correction Method and Missing Phenotypic Data on Genomic Prediction of Maize Hybrids

, 2018
Phenotypic datasets in plant breeding are commonly incomplete due to missing phenotypic information. The best approach for correcting these datasets for a stage-wise genomic prediction (GP) is not unanimous in the scientific community.
Galli, G, Lyra, D. H., Alves, F. C, Bandeira-Sousa, M., Granato, I. S. C., Fritsche-Neto, R   +5 more
core   +1 more source

Selected traits for genomic prediction.

, 2021
Selected traits for genomic prediction.
Guillaume P. Ramstein (5515949), Anju Giri (11520266), Edward S. Buckler (8844038), Merritt Khaipho-Burch (11520269)   +3 more
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Utilization Strategies of Two Environment Phenotypes in Genomic Prediction

, 2022
Multiple environment phenotypes may be utilized to implement genomic prediction in plant breeding, while it is unclear about optimal utilization strategies according to its different availability.
Jiaqi Li, Li, Jiaqi, Xiaodian Cai, Zhang, Zhe, Teng, Jinyan, Cai, Xiaodian, Zhe Zhang, Lin, Qing, Jinyan Teng, Qing Lin   +9 more
core   +1 more source