Results 71 to 80 of about 1,988,937 (263)

Genomic predictions under different genetic architectures are impacted by mating designs

Veterinary and Animal Science
Mating in animal communities must be managed in a way that assures the performance increase in the progenies without increasing the rate of inbreeding. It has currently become possible to identify millions of single nucleotide polymorphisms (SNPs), and ...
Sahar Ansari, Navid Ghavi Hossein-Zadeh, Abdol Ahad Shadparvar   +2 more
doaj   +1 more source

Genomic Prediction and Genetic Correlation of Agronomic, Blackleg Disease, and Seed Quality Traits in Canola (Brassica napus L.)

Plants, 2020
Genomic selection accelerates genetic progress in crop breeding through the prediction of future phenotypes of selection candidates based on only their genomic information.
Mulusew Fikere, Denise M. Barbulescu, M. Michelle Malmberg, Pankaj Maharjan, Phillip A. Salisbury, Surya Kant, Joe Panozzo, Sally Norton, German C. Spangenberg, Noel O. I. Cogan, Hans D. Daetwyler   +10 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Using machine learning to improve the accuracy of genomic prediction of reproduction traits in pigs

Journal of Animal Science and Biotechnology, 2022
Background Recently, machine learning (ML) has become attractive in genomic prediction, but its superiority in genomic prediction over conventional (ss) GBLUP methods and the choice of optimal ML methods need to be investigated.
Xue Wang, Shaolei Shi, Guijiang Wang, Wenxue Luo, Xia Wei, Ao Qiu, Fei Luo, Xiangdong Ding   +7 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

In silico miRNA prediction in metazoan genomes: balancing between sensitivity and specificity [PDF]

, 2009
Background MicroRNAs (miRNAs), short ~21-nucleotide RNA molecules, play an important role in post-transcriptional regulation of gene expression. The number of known miRNA hairpins registered in the miRBase database is rapidly increasing, but recent ...
Roeland CHJ van Ham, Ham, R.C.H.J., van, van der Burgt, A., Ate van der Burgt, Jan-Peter Nap, Mark WJE Fiers, van Ham Roeland CHJ, Fiers Mark WJE, Nap Jan-Peter, van der Burgt Ate, Burgt, A., van der, Fiers, M.W.E.J., Nap, J.P.H., van Ham, R.C.H.J.   +13 more
core   +1 more source

Enhancing Genomic Prediction Accuracy in Beef Cattle Using WMGBLUP and SNP Pre-Selection

Agriculture
Genomic selection (GS) plays a crucial role in livestock breeding. However, its implementation in Chinese beef cattle breeding is constrained by a limited reference population and incomplete data records.
Huqiong Zhao, Xueyuan Xie, Haoran Ma, Peinuo Zhou, Boran Xu, Yuanqing Zhang, Lingyang Xu, Huijiang Gao, Junya Li, Zezhao Wang, Xiaoyan Niu   +10 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Prediction of β-barrel membrane proteins by searching for restricted domains [PDF]

, 2005
BACKGROUND: The identification of beta-barrel membrane proteins out of a genomic/proteomic background is one of the rapidly developing fields in bioinformatics. Our main goal is the prediction of such proteins in genome/proteome wide analyses.
Mirus, O., Schleiff, Enrico, Oliver Mirus, Mirus, Oliver, Schleiff, E., Enrico Schleiff   +5 more
core   +1 more source