Results 51 to 60 of about 333,629 (311)

Accurate Genomic Prediction of Human Height [PDF]

Genetics, 2017
Abstract Hsu et al. used advanced methods from machine learning to analyze almost half a million genomes. They produced, for the first time, accurate genomic predictors for complex traits such as height, bone density, and educational attainment...
Lello, Louis, Avery, Steven G., Tellier, Laurent, Vazquez, Ana I., de los Campos, Gustavo, Hsu, Stephen D. H.   +5 more
openaire   +4 more sources

Comparison of Single-Trait and Multi-Trait GBLUP Models for Genomic Prediction in Red Clover

Agronomy
Red clover (Trifolium pratense) is a perennial forage legume wildly used in temperate regions, including northern Europe. Its breeders are under increasing pressure to obtain rapid genetic gains to meet the high demand for improved forage yield and ...
Johanna Osterman, Lucia Gutiérrez, Linda Öhlund, Rodomiro Ortiz, Cecilia Hammenhag, David Parsons, Mulatu Geleta   +6 more
doaj   +1 more source

Imputation of genotypes from low- to high-density genotyping platforms and implications for genomic selection

, 2011
peer-reviewedThe objective of this study was to quantify the accuracy achievable from imputing genotypes from a commercially available low-density marker panel (2730 single nucleotide polymorphisms (SNPs) following edits) to a commercially available ...
J.F. Kearney, Kearney, J.F., D.P. Berry, Berry, Donagh   +3 more
core   +1 more source

Exploring the genetic architecture and improving genomic prediction accuracy for mastitis and milk production traits in dairy cattle by mapping variants to hepatic transcriptomic regions responsive to intra-mammary infection

Genetics Selection Evolution, 2017
Background A better understanding of the genetic architecture of complex traits can contribute to improve genomic prediction. We hypothesized that genomic variants associated with mastitis and milk production traits in dairy cattle are enriched in ...
Lingzhao Fang, Goutam Sahana, Peipei Ma, Guosheng Su, Ying Yu, Shengli Zhang, Mogens Sandø Lund, Peter Sørensen   +7 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Genomic Prediction and Genetic Correlation of Agronomic, Blackleg Disease, and Seed Quality Traits in Canola (Brassica napus L.)

Plants, 2020
Genomic selection accelerates genetic progress in crop breeding through the prediction of future phenotypes of selection candidates based on only their genomic information.
Mulusew Fikere, Denise M. Barbulescu, M. Michelle Malmberg, Pankaj Maharjan, Phillip A. Salisbury, Surya Kant, Joe Panozzo, Sally Norton, German C. Spangenberg, Noel O. I. Cogan, Hans D. Daetwyler   +10 more
doaj   +1 more source

Genomic predictions in purebreds with a multibreed genomic relationship matrix1 [PDF]

Journal of Animal Science, 2019
AbstractCombining breeds in a multibreed evaluation can have a negative impact on prediction accuracy, especially if single nucleotide polymorphism (SNP) effects differ among breeds. The aim of this study was to evaluate the use of a multibreed genomic relationship matrix (G), where SNP effects are considered to be unique to each breed, that is ...
Yvette, Steyn, Daniela A L, Lourenco, Ignacy, Misztal   +2 more
openaire   +2 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Effect of breed composition in genomic prediction using crossbred pig reference population

Journal of Animal Science and Technology
In contrast to conventional genomic prediction, which typically targets a single breed and circumvents the necessity for population structure adjustments, multi-breed genomic prediction necessitates accounting for population structure to mitigate ...
Euiseo Hong, Yoonji Chung, Phuong Thanh N. Dinh, Yoonsik Kim, Suyeon Maeng, Young jae Choi, Jaeho Lee, Woonyoung Jeong, Hyunji Choi, Seung Hwan Lee   +9 more
doaj   +1 more source

Genomic Prediction Using Prior Quantitative Trait Loci Information Reveals a Large Reservoir of Underutilised Blackleg Resistance in Diverse Canola (Brassica napus L.) Lines

The Plant Genome, 2018
Genomic prediction is becoming a popular plant breeding method to predict the genetic merit of lines. While some genomic prediction results have been reported in canola, none have been evaluated for blackleg disease.
Mulusew Fikere, Denise M. Barbulescu, Michelle M. Malmberg, Fan Shi, Joshua C.O. Koh, Anthony T. Slater, Iona M. MacLeod, Phillip J. Bowman, Phillip A. Salisbury, German C. Spangenberg, Noel O.I. Cogan, Hans D. Daetwyler   +11 more
doaj   +1 more source