Results 31 to 40 of about 1,988,937 (263)

Genomics-aided structure prediction [PDF]

Proceedings of the National Academy of Sciences, 2012
We introduce a theoretical framework that exploits the ever-increasing genomic sequence information for protein structure prediction. Structure-based models are modified to incorporate constraints by a large number of non-local contacts estimated from direct coupling analysis (DCA) of co-evolving genomic sequences.
Sulkowska, Joanna I., Morcos, Faruck, Weigt, Martin, Hwa, Terence, Onuchic, Jose N.   +4 more
openaire   +3 more sources

Genomic Prediction of 16 Complex Disease Risks Including Heart Attack, Diabetes, Breast and Prostate Cancer

Scientific Reports, 2019
We construct risk predictors using polygenic scores (PGS) computed from common Single Nucleotide Polymorphisms (SNPs) for a number of complex disease conditions, using L1-penalized regression (also known as LASSO) on case-control data from UK Biobank ...
Louis Lello, Timothy G. Raben, Soke Yuen Yong, Laurent C. A. M. Tellier, Stephen D. H. Hsu   +4 more
doaj   +1 more source

Haplotype analysis of genomic prediction by incorporating genomic pathway information based on high-density SNP marker in Chinese yellow-feathered chicken

Poultry Science, 2023
: Genomic selection using single nucleotide polymorphism (SNP) markers is now intensively investigated in breeding and has been widely utilized for genetic improvement.
Haoqiang Ye, Zhenqiang Xu, Semiu Folaniyi Bello, Qianghui Zhu, Shaofen Kong, Ming Zheng, Xiang Fang, Xinzheng Jia, Haiping Xu, Xiquan Zhang, Qinghua Nie   +10 more
doaj   +1 more source

Accuracy of multi-trait genomic selection using different methods [PDF]

, 2011
Background Genomic selection has become a very important tool in animal genetics and is rapidly emerging in plant genetics. It holds the promise to be particularly beneficial to select for traits that are difficult or expensive to measure, such as traits
Veerkamp Roel F, Calus, M.P.L., Roel F Veerkamp, Calus Mario PL, Veerkamp, R.F., Mario PL Calus   +5 more
core   +1 more source

A classic approach for determining genomic prediction accuracy under terminal drought stress and well-watered conditions in wheat landraces and cultivars.

PLoS ONE, 2021
The present study aimed to improve the accuracy of genomic prediction of 16 agronomic traits in a diverse bread wheat (Triticum aestivum L.) germplasm under terminal drought stress and well-watered conditions in semi-arid environments.
Morteza Shabannejad, Mohammad-Reza Bihamta, Eslam Majidi-Hervan, Hadi Alipour, Asa Ebrahimi   +4 more
doaj   +1 more source

The effect of genomic information on optimal contribution selection in livestock breeding programs [PDF]

, 2013
Long-term benefits in animal breeding programs require that increases in genetic merit be balanced with the need to maintain diversity (lost due to inbreeding). This can be achieved by using optimal contribution selection.
Hickey, John M, Clark, Samuel A, John M Hickey, Brian P Kinghorn, van der Werf, Julius Hj, Samuel A Clark, Julius HJ van der Werf, Kinghorn, Brian P   +7 more
core   +1 more source

Predictive Genomics of Cardioembolic Stroke [PDF]

Stroke, 2009
Cardioembolic stroke is a complex disease resulting from the interaction of numerous factors. Using data from Genes Affecting Stroke Risk and Outcome Study (GASROS), we show that a multivariate predictive model built using Bayesian networks is able to achieve a predictive accuracy of 86% on the fitted values as computed by the area under the receiver ...
Rachel Badovinac, Ramoni, Blanca E, Himes, Michele M, Sale, Karen L, Furie, Marco F, Ramoni   +4 more
openaire   +2 more sources

Preselecting Variants from Large-Scale Genome-Wide Association Study Meta-Analyses Increases the Genomic Prediction Accuracy of Growth and Carcass Traits in Large White Pigs

Animals, 2023
Preselected variants associated with the trait of interest from genome-wide association studies (GWASs) are available to improve genomic prediction in pigs.
Chen Wei, Chengjie Chang, Wenjing Zhang, Duanyang Ren, Xiaodian Cai, Tianru Zhou, Shaolei Shi, Xibo Wu, Jinglei Si, Xiaolong Yuan, Jiaqi Li, Zhe Zhang   +11 more
doaj   +1 more source

A quantitative account of genomic island acquisitions in prokaryotes [PDF]

, 2011
Background Microbial genomes do not merely evolve through the slow accumulation of mutations, but also, and often more dramatically, by taking up new DNA in a process called horizontal gene transfer.
van Passel, Mark W. J., van Passel Mark WJ, Passel, M.W.J., van, Mark WJ van Passel, Roos Tom E, Roos, T.E., van Passel, M.W.J., Roos, Tom E., Tom E Roos   +8 more
core   +3 more sources

Multi-Trait Multi-Environment Genomic Prediction of Agronomic Traits in Advanced Breeding Lines of Winter Wheat

Frontiers in Plant Science, 2021
Genomic prediction is a promising approach for accelerating the genetic gain of complex traits in wheat breeding. However, increasing the prediction accuracy (PA) of genomic prediction (GP) models remains a challenge in the successful implementation of ...
Harsimardeep S. Gill, Jyotirmoy Halder, Jinfeng Zhang, Navreet K. Brar, Teerath S. Rai, Cody Hall, Amy Bernardo, Paul St Amand, Guihua Bai, Eric Olson, Shaukat Ali, Brent Turnipseed, Sunish K. Sehgal   +12 more
doaj   +1 more source