Results 21 to 30 of about 316,644 (265)

Predictive Genomics of Cardioembolic Stroke [PDF]

Stroke, 2009
Cardioembolic stroke is a complex disease resulting from the interaction of numerous factors. Using data from Genes Affecting Stroke Risk and Outcome Study (GASROS), we show that a multivariate predictive model built using Bayesian networks is able to achieve a predictive accuracy of 86% on the fitted values as computed by the area under the receiver ...
Rachel Badovinac, Ramoni, Blanca E, Himes, Michele M, Sale, Karen L, Furie, Marco F, Ramoni   +4 more
openaire   +2 more sources

Pan-genomic open reading frames: A potential supplement of single nucleotide polymorphisms in estimation of heritability and genomic prediction.

PLoS Genetics, 2020
Pan-genomic open reading frames (ORFs) potentially carry protein-coding gene or coding variant information in a population. In this study, we suggest that pan-genomic ORFs are promising to be utilized in estimation of heritability and genomic prediction.
Zhengcao Li, Henner Simianer
doaj   +1 more source

Maximum a posteriori Threshold Genomic Prediction Model for Ordinal Traits

G3: Genes, Genomes, Genetics, 2020
Due to the ever-increasing data collected in genomic breeding programs, there is a need for genomic prediction models that can deal better with big data.
Abelardo Montesinos-López, Humberto Gutierrez-Pulido, Osval Antonio Montesinos-López, José Crossa   +3 more
doaj   +1 more source

Genomic Prediction of 16 Complex Disease Risks Including Heart Attack, Diabetes, Breast and Prostate Cancer

Scientific Reports, 2019
We construct risk predictors using polygenic scores (PGS) computed from common Single Nucleotide Polymorphisms (SNPs) for a number of complex disease conditions, using L1-penalized regression (also known as LASSO) on case-control data from UK Biobank ...
Louis Lello, Timothy G. Raben, Soke Yuen Yong, Laurent C. A. M. Tellier, Stephen D. H. Hsu   +4 more
doaj   +1 more source

Haplotype analysis of genomic prediction by incorporating genomic pathway information based on high-density SNP marker in Chinese yellow-feathered chicken

Poultry Science, 2023
: Genomic selection using single nucleotide polymorphism (SNP) markers is now intensively investigated in breeding and has been widely utilized for genetic improvement.
Haoqiang Ye, Zhenqiang Xu, Semiu Folaniyi Bello, Qianghui Zhu, Shaofen Kong, Ming Zheng, Xiang Fang, Xinzheng Jia, Haiping Xu, Xiquan Zhang, Qinghua Nie   +10 more
doaj   +1 more source

Translating genomics into risk prediction [PDF]

Thorax, 2017
Cigarette smoking is a leading risk factor in the development of cardiovascular, pulmonary and malignant diseases worldwide.1 Yet, it remains one of the most challenging environmental exposures to quantify. Rudimentary categorisations of ‘never’, ‘former’ and ‘current’ smoker capture only a fraction of the complexity associated with the exposure ...
Emily S, Wan, Dawn L, DeMeo
openaire   +2 more sources

Systematic Evaluation of Genomic Prediction Algorithms for Genomic Prediction and Breeding of Aquatic Animals

Genes, 2022
The extensive use of genomic selection (GS) in livestock and crops has led to a series of genomic-prediction (GP) algorithms despite the lack of a single algorithm that can suit all the species and traits. A systematic evaluation of available GP algorithms is thus necessary to identify the optimal GP algorithm for selective breeding in aquaculture ...
Kuiqin Wang, Ben Yang, Qi Li, Shikai Liu
openaire   +2 more sources

A classic approach for determining genomic prediction accuracy under terminal drought stress and well-watered conditions in wheat landraces and cultivars.

PLoS ONE, 2021
The present study aimed to improve the accuracy of genomic prediction of 16 agronomic traits in a diverse bread wheat (Triticum aestivum L.) germplasm under terminal drought stress and well-watered conditions in semi-arid environments.
Morteza Shabannejad, Mohammad-Reza Bihamta, Eslam Majidi-Hervan, Hadi Alipour, Asa Ebrahimi   +4 more
doaj   +1 more source

Use of biological priors enhances understanding of genetic architecture and genomic prediction of complex traits within and between dairy cattle breeds

BMC Genomics, 2017
Background A better understanding of the genetic architecture underlying complex traits (e.g., the distribution of causal variants and their effects) may aid in the genomic prediction.
Lingzhao Fang, Goutam Sahana, Peipei Ma, Guosheng Su, Ying Yu, Shengli Zhang, Mogens Sandø Lund, Peter Sørensen   +7 more
doaj   +1 more source

GVCHAP: A Computing Pipeline for Genomic Prediction and Variance Component Estimation Using Haplotypes and SNP Markers

Frontiers in Genetics, 2020
Haplotype prediction models open many possibilities to improve the accuracy of genomic selection but require more data processing and computing time than single-SNP prediction models. To facilitate haplotype analysis for genomic prediction and estimation
Dzianis Prakapenka, Chunkao Wang, Zuoxiang Liang, Cheng Bian, Cheng Bian, Cheng Tan, Cheng Tan, Yang Da   +7 more
doaj   +1 more source