Results 21 to 30 of about 1,988,937 (263)

Implications of avoiding overlap between training and testing data sets when evaluating genomic predictions of genetic merit [PDF]

, 2010
The aim of this study was to evaluate and quantify the importance of avoiding overlap between training and testing subsets of data when evaluating the effectiveness of predictions of genetic merit based on genetic markers.
G. Banos, Amer, P. R., P.R. Amer, Banos, G.   +3 more
core   +1 more source

Prediction of operons in microbial genomes [PDF]

Nucleic Acids Research, 2001
Operon structure is an important organization feature of bacterial genomes. Many sets of genes occur in the same order on multiple genomes; these conserved gene groupings represent candidate operons. This study describes a computational method to estimate the likelihood that such conserved gene sets form operons.
M D, Ermolaeva, O, White, S L, Salzberg
openaire   +2 more sources

AUC-RF: A New Strategy for Genomic Profiling with Random Forest [PDF]

, 2011
Objective: Genomic profiling, the use of genetic variants at multiple loci simultaneously for the prediction of disease risk, requires the selection of a set of genetic variants that best predicts disease status.
Luz Calle, M., Nuria Malats, Urrea, Victor, Victor Urrea, Calle, M. Luz, Urrea Gales, Víctor, Anne-Laure Boulesteix, Boulesteix, Anne-Laure, Malats, Nuria, M. Luz Calle, Malats i Riera, Núria   +10 more
core   +1 more source

Increased Accuracy of Genomic Prediction Using Preselected SNPs from GWAS with Imputed Whole-Genome Sequence Data in Pigs

Animals, 2023
Enhancing the accuracy of genomic prediction is a key goal in genomic selection (GS) research. Integrating prior biological information into GS methods using appropriate models can improve prediction accuracy for complex traits.
Yiyi Liu, Yuling Zhang, Fuchen Zhou, Zekai Yao, Yuexin Zhan, Zhenfei Fan, Xianglun Meng, Zebin Zhang, Langqing Liu, Jie Yang, Zhenfang Wu, Gengyuan Cai, Enqin Zheng   +12 more
doaj   +1 more source

Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder [PDF]

, 2015
Genetic risk prediction has several potential applications in medical research and clinical practice and could be used, for example, to stratify a heterogeneous population of patients by their predicted genetic risk.
Caesar, Sian, Strohmaier, Jana, Wray, Naomi R., Wiersma D., Puri, Vinay, McGough J. J., Collier, David A., Myin-Germeys, Inez, Absher D., Chen, G. B., Loo, Sandra K., Wijsman E. M., Hallmayer, Joachim, Berrettini, Wade, Paterson A. D., Black D. W., Lathrop, Mark, Leboyer, Marion, Craddock, Nicholas, Lee, S Hong; id_orcid, Maier, R., Pato, Carlos N., Coryell W. H., Franke B., Datta S., Smalley, Susan L., Hansen, Thomas F., Zhang, Peng, Parr JR, Moser G., Santangelo S. L., Pericak-Vance M. A., Mühleisen, Thomas W., Van Os, Jim, Holmans, Peter Alan, Madden P. A. F., Hakonarson, Hakon, Nyholt, Dale R., Krabbendam, Lydia, Moser, Gerhard, State, Matthew, Landen M, De Geus E. J., Roeyers H., Freedman, Robert, Kent, Lindsey, Klauck S. M., Mahon, Pamela B., Gross, Magdalena, Freedman R., Duketis E., Sanders S. J., Nievergelt, Caroline M., Caesar S., Rouleau, Guy, Moreno-De-Luca, Daniel, Elia J., Farmer, Anne E., Hamilton, Steven P., Lesch K. -P., Lawrence J., Hipolito, Maria, Raychaudhuri, Soumya, Vicente, Astrid M., Schalling, Martin, Thapar, Anita, Kwan P., Lee, Sang Hong, Blackwood D. H. R., Craig D. W., Etain, Bruno, Boomsma, Dorret I., Kendler K. S., De Geus, Eco J., et al., Foroud, Tatiana, Gejman, Pablo V., Hickie I. B., Raychaudhuri S., Kennedy, James L., McQuillin, Andrew, Rossin L., Thirumalai S., Van Grootheest G., Ripke, Stephan, Pato, Michele T., Landén, Mikael, Ruderfer, Douglas, Lohoff F. W., Green E. K., Propping P., Maier R, Oliveira G., Kuntsi, Jonna, Li, Jun, Grice D. E., Kahler A. K., van den Oord, Edwin J.C.G., Kendler, Kenneth, other, and, Ribases M., McIntosh, Andrew; id_orcid, Shilling, Paul D., Lord C., Klauck, Sabine M., Kuntsi J., Rasmussen H. B., Vincent J. B., Faraone S. V., Levinson DF, Xu, Wei, Kohli M. A., Banaschewski, Tobias, Agartz I., Gross M., Frank, Josef, Hakonarson H., Tozzi, Federica, Myers R. M., Farmer, Anne, Morrow, Eric M., Wray N. R., Penninx B. W., Gershon E. S., Hong Lee, S., Weissman, Myrna M, Schachar R., Farmer A. E., Levinson, D. F., Doyle, Alysa E., Pato M. T., Santangelo, Susan L., Schellenberg G. D., Leboyer M., Georgieva, Lyudmila, Geschwind D. H., Lewis, Catrin, Coryell, W.H., Middeldorp C. M., Ingason A., Willemsen G., Kuntsi, Jonna; id_orcid, Willsey, A. Jeremy, Watson S. J., Sutcliffe, James, Etain B., Szatmari, Peter, Schwarz, Markus, Smith, Erin N., Psychiatric Genomics Consortium, Cross-Disorder Working Group of the, Hamilton S. P., O'Donovan, Michael Conlon, Medeiros H., Cantor R. M., Amin, Farooq, Visscher, Peter M., Cantor, Rita M., Kenny, Elaine, Hottenga, J.J., Cormand B., Linszen D. H., Smalley S. L., Tzeng J. -Y., McGhee, Kevin A., Vincent, John B., Daly, Mark J., Tzeng, Jung-Ying, Scott L. J., Gill M., Kahn, René S., Middeldorp, C.M., Potash, James B, Stroup, T. Scott, Coryell, William, Hautzinger, Martin, Breen, Gerome, Pickard, Benjamin S., Yu T. W., Olsen, Line, Nurnberger J. I., Vieland V. J., Giegling, Ina, Zandi, Peter P., Smith E. N., Quinn E. M., Tozzi F., Sonuga-Barke, E, Chambert K., Bayés, Mònica, Sullivan P. F., Choudhury, Khalid, McKinney, Rebecca, Medeiros, Helena, Rice, John P., Mowry B. J., Parr J. R., Lewis, Cathryn; id_orcid, Bauer, Michael, Martin, Nicholas G., Hultman, Christina M., Sonuga-Barke, Edmund; id_orcid, Landén, M., Cormican P., Smit J. H., Ingason, Andrés, Kim, Yunjung, Malhotra A. K., Roeder, Kathryn, Betancur C., Nwulia E. A., Shi, J., Cook, Edwin H., Rietschel, Marcella, Wienker T. F., Lande´n, Mikael, Shyn, Stanley I., van den Oord E. J. C. G., Zitman F. G., Van Grootheest, Gerard, Levinson D. F., McGuffin P., Binder E. B., Bayes M., Gill, Michael, Corvin, Aiden, McIntosh A., Owen, Michael J., Young A. H., State M., Akil H., Konte B., Duan, Jubao, Konte, Bettina, Moran J. L., Shi, J. X., Craddock N., Flickinger, Matthew, Nimgaonkar V., McKinney R., Gurling, Hugh, Hoefels, Susanne, Middleton, Lefkos, Schwarz M., Medland, Sarah E., Dawson G., Scott, Laura J., Lieberman J. A., Edenberg, Howard J., Edenberg H. J., Asherson, Philip, Nicol Ferrier I, Mattheisen, Manuel, Buccola N. G., Klei, Lambertus, Andreassen, Ole A., Nikolov I., Malhotra, Anil K., Pericak-Vance, Margaret A., Guan W., Purcell S. M., Nimgaonkar, Vishwajit, Young, Allan H., Kendler KS, Lichtenstein, Paul, Matthews K., Schalling M., Kendler, K. S., Coon H., Kohli, Martin A., Doyle A. E., Maier, Wolfgang, Langstrom N., Montgomery G. W., Franke, B., Backlund L., Smit, Johannes H., Breen G., MacIntyre D. J., Hultman CM, Palotie, Aarno, Hickie, Ian B., Kelsoe J. R., Nievergelt C. M., Heath A. C., Moskvina V., Kenny E., Lin, Dan-Yu, Collier D. A., Backlund, Lena, Shyn S. I., Quested D. J., Weissman, M.M., McCarroll S. A., Lucae S., Buccola, Nancy G., Levinson, Douglas, Holsboer F., Moreno-De-Luca D., Milanova V., Gordon, Scott D., Miranda, Ana, O’Donovan, Michael C., Wray, Naomi, Lencz T., Boehnke, Michael, Meyer, Jobst, Gordon-Smith, Katherine, Reif, Andreas, Kent L., Badner J. A., Lathrop M., Chen, G.B., Smoller, J. W., Amin F., Li J., Landen M., Coryell, W., Binder, Elisabeth B., Hartmann, Annette M., Hipolito M., Murtha M., Robert Cloninger C., Chen G-B, Lencz, Todd, Czamara, Darina, Frisén, Louise, McGrath P. J., Lichtenstein P., Middleton L., Nelson, Stan F., Green, Elaine K., St Clair D., Perlis, Roy H., Scherer S. W., Sanders A. R., Jones, Leslie, de Geus, E.J.C., Grice, Dorothy E., Willemsen, G.; id_orcid, Anjorin, Adebayo, Bettecken, Thomas, Keller, Matthew C., Morken G., Cook E. H., Gallagher L., Ennis S., Treutlein, Jens, Battaglia A., Schumacher J., Weissman MM, Hultman, Christina, Hoogendijk W. J., Cross-Disorder Working Group, of the Psychiatric Genomics Consortium, Myin-Germeys I., Anjorin A., Morrow E. M., Nolen W. A., Kwan, Phoenix, Neale, Benjamin M., Haines, Jonathan L., Grozeva, Detelina, Holmans P. A., Coryell, William H., Ebstein R. P., Freitag C. M., Cormican, Paul, Daly M. J., Cross-Disorder Working Group of the Psychiatric Genomics Consort,, Neale B. M., Frank J., McMahon W. M., McIntosh, Andrew, Kandaswamy, Radhika, Purcell, Shaun M., Friedl M., Buitelaar, J.K., Jones, Lisa, Bergen, Sarah E., Liu, Chunyu, Anney R., Steinhausen H. -C., Bass, Nicholas, Piven J., Fraser C., Chakravarti, Aravinda, Gershon, Elliot S., Rujescu, Dan, Rouleau G., Badner, Judith A., Foroud T., Frisen L., Schatzberg A. F., Bellivier F., Ramos-Quiroga, Josep Antoni, Strauss, John S., Scolnick E., Freimer N. B., Kahn R. S., Xu W., Shilling P. D., Hultman, C. M., Kirov, George K., Zollner S., Cuccaro M. L., Hottenga, Jouke-Jan, Thapar A., Lin D. -Y., Barchas J. D., Posthuma D., Williams, Nigel, Potash J. B., Lewis, Cathryn M., Osby, Urban, Cloninger, C. Robert, Wassink, Thomas H., Lee, S Hong, Jones I., Arking D. E., Fraser, Christine, Banaschewski T., Gurling H., Uhr M., Coryell W., Owen M. J., Dudbridge, Frank, Holmans, Peter A., Nurnberger, John I., Boehnke M., Lee, S. H., Scolnick, Edward, Breen, Gerome; id_orcid, Potash, James, Nöthen, Markus M., Holsboer, Florian, Nyholt, Dale, Klei L., Craig, David W., Van Os J., Henders, Anjali K., Puri V., Maier W., Zandi P. P., Maier, Robert, Scheftner, William A, Långström, Niklas, Datta, Susmita, Melle I., Herms, Stefan, Potash, James B., Wray, Naomi R, Scheftner, William, Propping, Peter, Boomsma D. I., Krasucki R., Krabbendam L., Ebstein, Richard P., Muglia P., McMahon, Francis J., Sklar, Pamela, Ledbetter, David H., Lowe, Jennifer K., Donohoe G. J., Middeldorp, Christel M., Ising M., Schork, Nicholas J., McGhee K. A., Kelsoe, John R., Hottenga J. -J., Young AH, Hoefels S., Azevedo M. H., Hallmayer J., Scheftner, W. A., Schulze T. G., Kendler, Kenneth S, Steinhausen, Hans-Christoph, Biederman, Joseph, Bergen S. E., Rujescu D., Jones L., Scheftner W. A., Hansen T. F., Mahon P. B., Silverman J. M., Ising, Marcus, Medland S. E., Cross-Disorder Working Group of the Psychiatric Genomics Consortium (incl Kent L), Fanous A., Magnusson, Patrik K.E., McMahon F. J., Andreassen O. A., Pimm J., Werge, Thomas, Kähler, Anna K., Weissman, Myrna M., Walsh, Christopher A., Kirov G. K., Shi, Jianxin, Barchas, Jack D., Szelinger, Szabocls, Roeder K., Bellivier, Frank, Olincy, Ann, Visscher P. M., Hultman, C.M., Jamain, Stéphane, Werge T., Georgieva L., Moran, Jennifer L., ?, ?, McMahon, William M., Thompson, Robert C., Maier R., Buxbaum, Joseph D., Guan, Weihua, Barrett, Thomas B., Moser, G., Zhang P., Smoller, J.W., Black, Donald W., Craig I. W., Ripke S, Milanova, Vihra, Landén, Mikael,, Ripke S., Day R., Rehnström, Karola, Day, Richard, Martin C. L., Cichon, Sven, Ribasés, Marta, Coryell W, Lord, Catherine, Wray, N.R., Zammit S., Kirov, George, Nikolov, Ivan, Penninx, Brenda W., Schulze, Thomas G., Todorov, Alexandre A., Cuccaro, Michael L., Keller M. C., Sanders, Alan R., Bass N., Sullivan, Patrick F., Moskvina, Valentina, Oades, Robert D., St Clair, David, Freimer, Nelson B., Bunney, William E., Lee P. H., Byerley, William F., Moser G, Arking, Dan E., Mane, Shrikant M., Weiss L. A., O'Dushlaine C., Lee, Phil H., Smoller J. W., Rice J. P., Absher, Devin, Choudhury K., Craig, Ian, Cross-Disorder Working Group of the Psychiatric Genomics Consortium, Scheftner WA, Chen G. -B., Pimm, Jonathan, Smoller, Jordan, Linszen, Don H., Wienker, Thomas F., Koller, Daniel L., Müller-Myhsok, Bertram, Scheftner, W.A., Ferrier, I. Nicol, Loo S. K., Liu C., Slager, Susan L., Byerley W. F., Maestrini E., Ennis, Sean, Paterson, Andrew D., Breuer R., Lee, S. Hong, Lucae, Susanne, Jamain S., Craig, Ian W., Young, Allan; id_orcid, Korszun, Ania, Casas M., Pergadia, Michele L., Koller D. L., Muglia, Pierandrea, Thirumalai, Srinivasa, Giegling I., McQuillin A., Maestrini, Elena, Flickinger M., Corvin A., Schellenberg, Gerard D., Cichon S., Donohoe, Gary J., Rasmussen, Henrik B., Steffens, Michael, Witt, Stephanie H., Djurovic S., Posthuma, Danielle, Wijsman, Ellen M., Hus V., Martin N. G., Meyer J., Slager S. L., Kendler, Kenneth S., Lesch, Klaus-Peter, Potash, J.B., Asherson P., Dawson, Geraldine, Mattheisen M., Hamshere M. L., Ledbetter D. H., Hultman, Christina M, Cormand, Bru, Duan J., Weissman, M. M., Monaco, Anthony P., Zöllner, Sebastian, Djurovic, Srdjan, Coon, Hilary, Lawrence, Jacob, McLean, Alan W., Barnes M. R., Yu, Timothy W., Sonuga-Barke, Edmund J.S., Williams N., Ripke, S, Silverman, Jeremy M., Franke, Barbara, Jones, Ian Richard, Ophoff, Roel A., Azevedo, Maria H., Chen, G., Pato C. N., Cahn W., Jeremy Willsey A., Todorov A. A., Buitelaar J. K., Schumacher, Johannes, Ophoff R. A., Scott Stroup T., Buitelaar, Jan K., Potash JB, Uhr, Manfred, Meier S., Meier, Sandra, Korszun A., Breuer, René, Bloss, Cinnamon S., Montgomery, Grant W., Smoller, Jordan W., Anney, Richard, Weissman, Myrna, Murtha, Michael, De Haan, Lieuwe, Gordon-Smith K., Quinn, Emma M., Nelson S. F., Hoogendijk, Witte J., Degenhardt, Franziska, Lowe J. K., Rothenberger A., Quested, Digby J., Barrett T. B., Oades R. D., Devlin B., Szatmari P., Asherson, Philip; id_orcid, Nolen, Willem A., Knowles, James A., Grozeva D., Vieland, Veronica J., Thompson R. C., Gejman P. V., De Haan L., Vicente A. M., Perlis R. H., Knowles J. A., Freitag, Christine M., Hautzinger M., Nyholt D. R., Bruggeman, Richard, Ramos-Quiroga J. A., McInnis M. G., Chakravarti A., Meng F., Faraone, Stephen V., Martin, Christa L., Szelinger S., Lee SH, Fombonne E., Palotie A., Degenhardt F., Lawson, William B., Mowry, Bryan J., Devlin, Bernie, Levinson, D.F., Kendler, K.S., Olsen L., Sanders, Stephan J., Miranda A., Scheftner, William A., Potash, J. B., Sutcliffe J., Sergeant, Joseph A., Elia, Josephine, Krasucki, Robert, Morris, Derek W., MacIntyre, Donald J., Witt S. H., Scherer, Stephen W., Hus, Vanessa, Magnusson P. K. E., Duketis, Eftichia, Hamshere, Marian L., Piven, Joseph, Willemsen, Gonneke, Mattingsdal, Morten, Sonuga-Barke E. J. S., Bruggeman R., Nicol Ferrier I., Olincy A., de Geus, E.J.C.; id_orcid, Wiersma, Durk, Wray NR, Morris D. W., Wassink T. H., Madden, Pamela A.F., Hultman C. M., Curtis, David, Rietschel M., Czamara D., Schachar, Russell, Watson, Stanley J., Greenwood T. A., Treutlein J., Cahn, Wiepke, Lohoff, Falk W., Chambert, Kimberly, Biederman J., Hartmann A. M., Melle, Ingrid, Myers, Richard M., Chen, Guo-Bo, Boomsma, D.I.; id_orcid, Rossin, Lizzy, O'Donovan M. C., Poustka F., Crosbie J., Curtis D., Greenwood, Tiffany A., Bailey, Anthony J., Henders A. K., Zammit, Stanley, Friedl, Marion, O’Dushlaine, Colm, Owen, Michael John, Zitman, Frans G., Bloss C. S., Lewis C. M., Buxbaum J. D., Bauer M., Casas, Miguel, McGrath, Patrick J., Bailey A. J., Pergadia M. L., Morken, Gunnar, Levinson, Douglas F, Lee, S.H., Betancur, Catalina, Walsh C. A., Weissman M. M., Steffens M., Mane S. M., Muller-Myhsok B., Nothen M. M., Monaco A. P., Fombonne, Eric, Roeyers, Herbert, Agartz, Ingrid, Rehnstrom K., Weiss, Lauren A., Bettecken T., Strohmaier J., Schatzberg, Alan F., Reif A., Ripke, S., Rothenberger, Aribert, Schork N. J., Shi J, Poustka, Fritz, Wray, N. R., Lee S. H., Gallagher, Louise, Smoller JW, Weissmann, M.M., Kandaswamy R., Levinson, Douglas F., Gordon S. D., Parr, Jeremy R., Lieberman, Jeffrey A., Willemsen, G., Kennedy J. L., Cross-Disorder Working Group of the Psychiatric Genomics, Consortium., Sklar P., Barnes, Michael R., Boomsma, D.I., Lawson W. B., Meng, Fan, Smoller, Jordan W, Osby U., Akil, Huda, McGough, James J., Shi J., Jones, Ian, Muhleisen T. W., Matthews, Keith, Strauss J. S., Haines J. L., Mattingsdal M., Geschwind, Daniel H., Herms S., Sergeant J. A., Oliveira, Guiomar, Nwulia, Evaristus A., Ruderfer D., Battaglia, Agatino, McInnis, Melvin G., Berrettini W., Dudbridge F., Pickard B. S., McGuffin, Peter, McCarroll, Steven A., Bunney W. E., Kim Y., McLean A. W., Crosbie, Jennifer, Heath, Andrew C., Blackwood, Douglas H.R., Fanous, Ayman, Moser, G, Coryell, W, Hultman, CM, Scheftner, WA, Lencz, T., Weissman, MM, +7 additional authors, Smoller, J., Chen, G-B, Potash, JB, Maier, R, Shi, J   +858 more
core   +3 more sources

Pan-genomic open reading frames: A potential supplement of single nucleotide polymorphisms in estimation of heritability and genomic prediction.

PLoS Genetics, 2020
Pan-genomic open reading frames (ORFs) potentially carry protein-coding gene or coding variant information in a population. In this study, we suggest that pan-genomic ORFs are promising to be utilized in estimation of heritability and genomic prediction.
Zhengcao Li, Henner Simianer
doaj   +1 more source

Pre-selecting markers based on fixation index scores improved the power of genomic evaluations in a combined Yorkshire pig population

Animal, 2020
Combining different swine populations in genomic prediction can be an important tool, leading to an increased accuracy of genomic prediction using single nucleotide polymorphism (SNP) chip data compared with within-population genomic.
S. Ye, H. Song, X. Ding, Z. Zhang, J. Li
doaj   +1 more source

Effects of the number of markers per haplotype and clustering of haplotypes on the accuracy of QTL mapping and prediction of genomic breeding values [PDF]

, 2009
The aim of this paper was to compare the effect of haplotype definition on the precision of QTL-mapping and on the accuracy of predicted genomic breeding values.
Veerkamp Roel F, Theo HE Meuwissen, Egbert F Knol, Addie LJ Vereijken, Calus Mario PL, Vereijken Addie LJ, Knol, E.F., Schrooten, C., Windig, J.J., Meuwissen Theo HE, Knol Egbert F, Calus, M.P.L., Vereijken, A.L.J., Roel F Veerkamp, Jack J Windig, Windig Jack J, Veerkamp, R.F., Chris Schrooten, Schrooten Chris, Meuwissen, T.H.E., Mario PL Calus   +20 more
core   +1 more source

Maximum a posteriori Threshold Genomic Prediction Model for Ordinal Traits

G3: Genes, Genomes, Genetics, 2020
Due to the ever-increasing data collected in genomic breeding programs, there is a need for genomic prediction models that can deal better with big data.
Abelardo Montesinos-López, Humberto Gutierrez-Pulido, Osval Antonio Montesinos-López, José Crossa   +3 more
doaj   +1 more source

Comparison of analyses of the QTLMAS XIV common dataset. I: genomic selection [PDF]

, 2011
Background - For the XIV QTLMAS workshop, a dataset for traits with complex genetic architecture has been simulated and released for analyses by participants. One of the tasks was to estimate direct genomic values for individuals without phenotypes.
Tomasz Strabel, Pszczola, M.J., Sebastian Mucha, Mucha, S., Marcin Pszczola, Strabel, T., Wolc, A., Szydlowski, M., Anna Wolc, Maciej Szydlowski   +9 more
core   +1 more source