Results 61 to 70 of about 2,453,732 (306)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Genomic Prediction Using Prior Quantitative Trait Loci Information Reveals a Large Reservoir of Underutilised Blackleg Resistance in Diverse Canola (Brassica napus L.) Lines

The Plant Genome, 2018
Genomic prediction is becoming a popular plant breeding method to predict the genetic merit of lines. While some genomic prediction results have been reported in canola, none have been evaluated for blackleg disease.
Mulusew Fikere, Denise M. Barbulescu, Michelle M. Malmberg, Fan Shi, Joshua C.O. Koh, Anthony T. Slater, Iona M. MacLeod, Phillip J. Bowman, Phillip A. Salisbury, German C. Spangenberg, Noel O.I. Cogan, Hans D. Daetwyler   +11 more
doaj   +1 more source

Genomic predictions in purebreds with a multibreed genomic relationship matrix1 [PDF]

Journal of Animal Science, 2019
AbstractCombining breeds in a multibreed evaluation can have a negative impact on prediction accuracy, especially if single nucleotide polymorphism (SNP) effects differ among breeds. The aim of this study was to evaluate the use of a multibreed genomic relationship matrix (G), where SNP effects are considered to be unique to each breed, that is ...
Yvette, Steyn, Daniela A L, Lourenco, Ignacy, Misztal   +2 more
openaire   +2 more sources

List of SNP markers for Genomic prediction

, 2023
We described the methodology used to select highly informative SNP markers to be used for genomic selection and prediction for yam 
Paterne AGRE (13848226)
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Effect of breed composition in genomic prediction using crossbred pig reference population

Journal of Animal Science and Technology
In contrast to conventional genomic prediction, which typically targets a single breed and circumvents the necessity for population structure adjustments, multi-breed genomic prediction necessitates accounting for population structure to mitigate ...
Euiseo Hong, Yoonji Chung, Phuong Thanh N. Dinh, Yoonsik Kim, Suyeon Maeng, Young jae Choi, Jaeho Lee, Woonyoung Jeong, Hyunji Choi, Seung Hwan Lee   +9 more
doaj   +1 more source

Multivariate GBLUP Improves Accuracy of Genomic Selection for Yield and Fruit Weight in Biparental Populations of Vaccinium macrocarpon Ait

Frontiers in Plant Science, 2018
The development of high-throughput genotyping has made genome-wide association (GWAS) and genomic selection (GS) applications possible for both model and non-model species.
Giovanny Covarrubias-Pazaran, Brandon Schlautman, Luis Diaz-Garcia, Luis Diaz-Garcia, Edward Grygleski, James Polashock, Jennifer Johnson-Cicalese, Nicholi Vorsa, Massimo Iorizzo, Juan Zalapa   +9 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Asymmetric attrition and secondary chromosome destabilization after double-strand breaks in human embryonic development

Nature Communications
DNA repair in human embryos is poorly understood, and double-strand breaks (DSBs) can cause chromosome loss. We show that chromosomal alterations relative to an induced DSB are asymmetric: acentric arms show complementary gains and losses, while centric ...
Jenna Turocy, Stepan Jerabek, Woonyung Hur, Jimin Kim, Shuangyi Xu, Qiaojin Zhao, Jia Xu, Alex Robles, Xiangyi Liu, Nathan Treff, Diego Marin, Anna-Katerina Hadjantonakis, Dieter Egli   +12 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source