Results 61 to 70 of about 1,988,937 (263)

Genomic Prediction Using Prior Quantitative Trait Loci Information Reveals a Large Reservoir of Underutilised Blackleg Resistance in Diverse Canola (Brassica napus L.) Lines

open access: yesThe Plant Genome, 2018
Genomic prediction is becoming a popular plant breeding method to predict the genetic merit of lines. While some genomic prediction results have been reported in canola, none have been evaluated for blackleg disease.
Mulusew Fikere   +11 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Genomic selection in dairy cattle [PDF]

open access: yes, 2011
The objectives of this Ph.D. thesis were (1) to optimise genomic selection in dairy cattle with respect to the accuracy of predicting total genetic merit and (2) to optimise a dairy cattle breeding program using genomic selection. The study was performed
de Roos, A.P.W., Roos, A.P.W., de
core  

Effect of breed composition in genomic prediction using crossbred pig reference population

open access: yesJournal of Animal Science and Technology
In contrast to conventional genomic prediction, which typically targets a single breed and circumvents the necessity for population structure adjustments, multi-breed genomic prediction necessitates accounting for population structure to mitigate ...
Euiseo Hong   +9 more
doaj   +1 more source

Multivariate GBLUP Improves Accuracy of Genomic Selection for Yield and Fruit Weight in Biparental Populations of Vaccinium macrocarpon Ait

open access: yesFrontiers in Plant Science, 2018
The development of high-throughput genotyping has made genome-wide association (GWAS) and genomic selection (GS) applications possible for both model and non-model species.
Giovanny Covarrubias-Pazaran   +9 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Asymmetric attrition and secondary chromosome destabilization after double-strand breaks in human embryonic development

open access: yesNature Communications
DNA repair in human embryos is poorly understood, and double-strand breaks (DSBs) can cause chromosome loss. We show that chromosomal alterations relative to an induced DSB are asymmetric: acentric arms show complementary gains and losses, while centric ...
Jenna Turocy   +12 more
doaj   +1 more source

Multi-environment analysis enhances genomic prediction accuracy of agronomic traits in sesame

open access: yesFrontiers in Genetics, 2023
Introduction: Sesame is an ancient oilseed crop containing many valuable nutritional components. The demand for sesame seeds and their products has recently increased worldwide, making it necessary to enhance the development of high-yielding cultivars ...
Idan Sabag   +4 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Computational methods for splice site prediction [PDF]

open access: yes, 2006
Taher L. Computational methods for splice site prediction. Bielefeld (Germany): Bielefeld University; 2006.Completing the genome sequence of a given organism is just the beginning of a series of subsequent tasks, namely, the discovery of the ...
Taher, Leila
core  

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