Results 111 to 120 of about 1,988,937 (263)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Meeting report : 1st international functional metagenomics workshop May 7–8, 2012, St. Jacobs, Ontario, Canada [PDF]

, 2012
This report summarizes the events of the 1st International Functional Metagenomics Workshop. The workshop was held on May 7 and 8 in St. Jacobs, Ontario, Canada and was focused on building a core international functional metagenomics community, exploring
David R. Rose, Charles, Trevor, Valla, Svein, Reid, Alexandra, Kornelia Smalla, John Doemer, Edwards, Elizabeth A., Smalla, K., Alexandra Reid, Katja Engel, Moreno-Hagelsieb, Gabriel, Charles, Trevor C., Cheng-Cang Wu, Trevor C. Charles, Reid, A., Sean F. Brady, Sjöling, Sara, Liles, Mark R., Brady, Sean F., Sara Sjöling, Sjöling, Sara,, David A. Mead, Eric C. Martens, O’gara, Fergal, Streit, Wolfgang R., Sessitsch, Angela, Wellington, Elizabeth M.H., Edwards, E. A., Simonet, Pascal, Jennifer Tedman-Jones, O’Gara, F., Neufeld, Joseph D., Wolfgang R. Streit, Ashby, Deborah, Elizabeth A. Edwards, Wu, Cheng-Cang, Wellington, Elizabeth, Neufeld, Josh D., Fiebig, Klaus, Tedman-Jones, Jennifer, Martens, Erik C., Martens, Eric C., Angela Sessitsch, Engel, Katja, Doemer, John, Fergal O’Gara, Cowan, Don A., Miyazaki, Kentaro, Klaus Fiebig, Elizabeth M. H. Wellington, Pascal Simonet, Don A. Cowan, Rose, David R., Mark R. Liles, Smalla, Kornelia, Josh D. Neufeld, Wellington, Elizabeth M. H., Svein Valla, Kentaro Miyazaki, Gabriel Moreno-Hagelsieb, Deborah Ashby, Dennis McCormac, Wellington, E. M. H., McCormac, Dennis, O'Gara, Fergal, Mead, David A.   +65 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Deep Kernel for Genomic and Near Infrared Predictions in Multi-environment Breeding Trials

G3: Genes, Genomes, Genetics, 2019
Kernel methods are flexible and easy to interpret and have been successfully used in genomic-enabled prediction of various plant species. Kernel methods used in genomic prediction comprise the linear genomic best linear unbiased predictor (GBLUP or GB ...
Jaime Cuevas, Osval Montesinos-López, Philomin Juliana, Carlos Guzmán, Paulino Pérez-Rodríguez, José González-Bucio, Juan Burgueño, Abelardo Montesinos-López, José Crossa   +8 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Genomic variations define divergence of water/wildlife-associated Campylobacter jejuni niche specialists from common clonal complexes [PDF]

, 2011
Although the major food-borne pathogen Campylobacter jejuni has been isolated from diverse animal, human and environmental sources, our knowledge of genomic diversity in C.
French, Nigel P., Hinds, Jason, Hall, N, Hepworth, Philip J., Gould, Katherine A., Gould, Katherine A, Adam A. Witney, Ashelford, Kevin E., Birtles, Richard J, Philip J. Hepworth, Kevin E. Ashelford, Nicola J. Williams, Winstanley, Craig, Howard Leatherbarrow, Wren, BW, Witney, AA, Birtles, Richard J., Neil Hall, French, Nigel P, Katherine A. Gould, Witney, Adam A., Hinds, J, Williams, Nicola J., Jason Hinds, Nigel P. French, Winstanley, C, Leatherbarrow, Howard, Paul Wigley, Williams, Nicola J, Birtles, RJ, Wren, Brendan W, Craig Winstanley, Mendonca, C, Mendonca, Chriselle, Hepworth, Philip J, Gould, KA, Wigley, Paul, Brendan W. Wren, Wren, Brendan W., Nick Dorrell, French, NP, Wigley, P, Hepworth, PJ, Leatherbarrow, H, Williams, NJ, Witney, Adam A, Dorrell, Nick, Chriselle Mendonca, Hall, Neil, Dorrell, N, Ashelford, KE, Ashelford, Kevin E, Richard J. Birtles   +52 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Estimating quantitative genetic parameters in wild populations:A comparison of pedigree and genomic approaches [PDF]

, 2014
The estimation of quantitative genetic parameters in wild populations is generally limited by the accuracy and completeness of the available pedigree information. Using relatedness at genome-wide markers can potentially remove this limitation and lead to
Pemberton, Josephine M, Ellis, Philip A., Pemberton, Josephine M., Bérénos, Camillo, Ellis, Philip A, Pilkington, Jill G., Pilkington, Jill G   +6 more
core   +1 more source

Enhancing genomic prediction of wheat resistance to Fusarium head blight through integration of passive resistance traits

Frontiers in Plant Science
Fusarium head blight (FHB) is one of the most devastating wheat diseases worldwide. Wheat resistance to FHB is controlled by multiple small-effect genes involved in active and passive resistance mechanisms.
Andrii Gorash, Shayan Syed, Gintaras Brazauskas   +2 more
doaj   +1 more source