Results 111 to 120 of about 333,629 (311)

Deep Kernel for Genomic and Near Infrared Predictions in Multi-environment Breeding Trials

G3: Genes, Genomes, Genetics, 2019
Kernel methods are flexible and easy to interpret and have been successfully used in genomic-enabled prediction of various plant species. Kernel methods used in genomic prediction comprise the linear genomic best linear unbiased predictor (GBLUP or GB ...
Jaime Cuevas, Osval Montesinos-López, Philomin Juliana, Carlos Guzmán, Paulino Pérez-Rodríguez, José González-Bucio, Juan Burgueño, Abelardo Montesinos-López, José Crossa   +8 more
doaj   +1 more source

TACOA - Taxonomic classification of environmental genomic fragments using a kernelized nearest neighbor approach

, 2009
Diaz NN, Krause L, Goesmann A, Niehaus K, Nattkemper TW. TACOA - Taxonomic classification of environmental genomic fragments using a kernelized nearest neighbor approach. BMC Bioinformatics.
Nattkemper, Tim Wilhelm ; https://orcid.org/, Nattkemper Tim W, Naryttza N Diaz, Lutz Krause, Krause, Lutz, Niehaus Karsten, Diaz Naryttza N, Goesmann, Alexander ; https://orcid.org/, Goesmann Alexander, Niehaus, Karsten, Tim W Nattkemper, Goesmann, Alexander, Karsten Niehaus, Diaz, Naryttza N., Nattkemper, Tim W., Krause Lutz, Alexander Goesmann   +16 more
core   +1 more source

Genomics and predictive medicine

The Siberian Journal of Clinical and Experimental Medicine, 2021
Progress in understanding of structural and functional human genome organization and deciphering primary DNA sequence in human cells allowed for hitherto unreachable new capabilities of medical genetics in identifying the causes and mechanisms of inherited and inborn pathology.
openaire   +2 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

A clinical grid infrastructure supporting adverse hypotensive event prediction [PDF]

, 2009
The condition of hypotension - where a person's arterial blood pressure drops to an abnormally low level - is a common and potentially fatal occurrence in patients under intensive care. As medical interventions to treat such events are typically reactive
Jiang, J., Richard Sinnott, Jipu Jiang, Sinnott, R.O., Stell, A.J., Anthony Stell   +5 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Optimizing clinico-genomic disease prediction across ancestries: a machine learning strategy with Pareto improvement

Genome Medicine
Background Accurate prediction of an individual’s predisposition to diseases is vital for preventive medicine and early intervention. Various statistical and machine learning models have been developed for disease prediction using clinico-genomic data ...
Yan Gao, Yan Cui
doaj   +1 more source

Integrating Gene Expression Data into Single-Step Method (ssBLUP) Improves Genomic Prediction Accuracy for Complex Traits of Duroc × Erhualian F₂ Pig Population

Current Issues in Molecular Biology
The development of multi-omics has increased the likelihood of further improving genomic prediction (GP) of complex traits. Gene expression data can directly reflect the genotype effect, and thus, they are widely used for GP.
Fangjun Xu, Zhaoxuan Che, Jiakun Qiao, Pingping Han, Na Miao, Xiangyu Dai, Yuhua Fu, Xinyun Li, Mengjin Zhu   +8 more
doaj   +1 more source

Modeling copy number variation in the genomic prediction of maize hybrids

, 2019
Non-additive effects resulting from the actions of multiple loci may influence trait variation in single-cross hybrids. In addition, complementation of allelic variation could be a valuable contributor to hybrid genetic variation, especially when ...
Alves, F. C., Morosini, Júlia Silva, Massaine Bandeira e Sousa, Filipe Couto Alves, Morosini, J. S., Vidotti, Miriam Suzane, Fritsche-Neto, R., Júlia Silva Morosini, Granato, Ítalo Stefanine Correia, Granato, I. S. C., Danilo Hottis Lyra, Vidotti, M. S., Miriam Suzane Vidotti, Roberto Fritsche-Neto, Lyra, D. H., Giovanni Galli, Crossa, J., Fritsche-Neto, Roberto, Sousa, M. B., Ítalo Stefanine Correia Granato, Lyra, Danilo Hottis, Crossa, José, Galli, Giovanni, Alves, Filipe Couto, José Crossa, Galli, G., Bandeira e Sousa, Massaine   +26 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source