Results 201 to 210 of about 301,899 (294)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Multivariate models improve accuracy of genomic prediction for spring frost tolerance in Norway spruce. [PDF]

Plant Genome
Aro T, Tan B, Chen ZQ, Hallingbäck H, Suontama M, Westin J, Wu H, Hurry V.   +7 more
europepmc   +1 more source

Genomic Prediction in Pea: Effect of Marker Density and Training Population Size and Composition on Prediction Accuracy [PDF]

, 2015
Nadim Tayeh, Anthony Klein, Marie‐Christine Le Paslier, Françoise Jacquin, Hervé Houtin, Céline Rond, Marianne Chabert-Martinello, Jean-Bernard Magnin-Robert, Pascal Marget, Grégoire Aubert, Judith Burstin   +10 more
openalex   +1 more source

Harnessing Non‐Covalent Protein–Protein Interaction Domains for Production of Biocatalytic Materials Systems

Advanced Functional Materials, EarlyView.
Non‐covalent protein–protein interactions mediated by SH3, PDZ, or GBD domains enable the self‐assembly of stable and biocatalytically active hydrogel materials. These soft materials can be processed into monodisperse foams that, once dried, exhibit enhanced mechanical stability and activity and are easily integrated into microstructured flow ...
Julian S. Hertel, Maria Alessandra Martini, Marius Stoeckle, Annika J. Weber, Kersten S. Rabe, Christof M. Niemeyer   +5 more
wiley   +1 more source

A Deep Autoencoder Compression-Based Genomic Prediction Method for Whole-Genome Sequencing Data. [PDF]

Biology (Basel)
Song H, Dong T, Wang W, Yan X, Geng C, Bai S, Hu H.   +6 more
europepmc   +1 more source

Tester and Environment Affecting Genomic Prediction in Exotic Maize Germplasm and Derivation Penal in China [PDF]

Qi Sun, Jianjun Wang, Zhaohua Ding, Tingru Zeng, Shouping Lu, Meng Zhao, Wencai Li, Zhaodong Meng   +7 more
openalex   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Genomic prediction models for morpho-phenological traits in durum wheat based on Vrn, Ppd, and Rht alleles. [PDF]

Plant Genome
Puglisi D, Afshari-Behbahanizadeh S, Angione G, Colella I, Fania F, Spadanuda P, Esposito S, De Vita P.   +7 more
europepmc   +1 more source

Integrative Harmonization of Phenotypic and Genomic Data Improves Bone Mineral Density Prediction in Multi‐Study Osteoporosis Research [PDF]

Anqi Liu, Jianing Liu, Lang Wu, Qing Wu
openalex   +1 more source

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source