Results 241 to 250 of about 551,388 (334)

Porous Silicon Nanoneedles Efficiently Deliver Adenine Base Editor to Correct a Recurrent Pathogenic COL7A1 Variant in Recessive Dystrophic Epidermolysis Bullosa

Advanced Materials, EarlyView.
Base editing using nanoneedles efficiently corrects pathogenic variants in the type VII collagen gene of primary fibroblasts from patients with recessive dystrophic epidermolysis bullosa. Nanoneedle editing induces minimal and reversible transcriptional perturbations while restoring the production and secretion of functional type VII collagen.
Salman Ahmad Mustfa, Marija Dimitrievska, Cong Wang, Chenlei Gu, Ningjia Sun, Katarzyna Romańczuk, Pawel Karpinski, Łukasz Łaczmański, John A. McGrath, Joanna Jacków‐Malinowska, Ciro Chiappini   +10 more
wiley   +1 more source

Balancing Sensitivity and Specificity Enhances Top and Bottom Ranking in Genomic Prediction of Cultivars. [PDF]

Plants (Basel)
Montesinos-López OA, Kismiantini, Alemu A, Montesinos-López A, Montesinos-López JC, Crossa J.   +5 more
europepmc   +1 more source

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

Genomic prediction with kinship-based multiple kernel learning produces hypothesis on the underlying inheritance mechanisms of phenotypic traits. [PDF]

Genome Biol
Raimondi D, Verplaetse N, Passemiers A, Jans DS, Cleynen I, Moreau Y.   +5 more
europepmc   +1 more source

PNA Functionalized Gold Nanoparticles on TiO2 Nanotubes Biosensor for Electrochemical DNA Fragment Detection

Advanced Materials Interfaces, EarlyView.
This experiment investigates the development of a highly sensitive biosensor platform incorporating AuNPs with TiO2‐NTs as electrode materials. Robust PNA probes and an optimized hybridization protocol are employed to enhance performance. An appropriate level of AuNPs on the surface effectively prevents non‐specific binding of target DNA fragments ...
Younghwan Kim, Swomitra Kumar Mohanty
wiley   +1 more source

Terahertz Metamaterial Sensors: Design Theory, Optimization Approach, and Advancements in Biosensing Applications

Advanced Materials Technologies, EarlyView.
This review provides an in‐depth overview of the design principles and optimization strategies for terahertz (THz) metamaterials (MMs) sensors based on the dielectric perturbation theory. Various structures and methods are explored to enhance sensor performance, focusing on improving sensitivity and Q‐factor.
Lei Cao, Shanshan Jia, Fanqi Meng, Merle Richter, Yannik Loth, Anna Katharina Wigger, Chenglin Yang, Liuyang Zhang, Peter Haring Bolívar, Hartmut G. Roskos   +9 more
wiley   +1 more source

Machine learning-enhanced multi-trait genomic prediction for optimizing cannabinoid profiles in cannabis. [PDF]

Plant J
Yoosefzadeh Najafabadi M, Torkamaneh D.
europepmc   +1 more source

3P297 Development of structure prediction server and model quality assessment platform for proteins(Bioinformatics: Structural genomics,The 48th Annual Meeting of the Biophysical Society of Japan)

, 2010
Shugo Nakamura, Mizuki Morita, Masanori Kakuta, Kentaro Shimizu   +3 more
openalex   +2 more sources

Autologous Peripheral Vγ9Vδ2 T Cell Synergizes with αβ T Cell Through Antigen Presentation and BTN3A1 Blockade in Immunotherapy of Cervical Cancer

Advanced Science, EarlyView.
This study provides proof‐of‐concept evidence showing that through direct killing, antigen presentation, and competitively binding to BTN3A1, Vγ9Vδ2 T cells amplified from cervical cancer (CC) patients can synergize with αβ T cells to exert anti‐CC function both in vitro and in vivo.
Min Wu, Jian Liu, Liting Liu, Yifan Yang, Hong Liu, Long Yu, Haihong Zeng, Shuo Yuan, Ruiyi Xu, Hangyu Liu, Han Jiang, Shen Qu, Liming Wang, Ying Chen, Jingyu Wang, Yuwei Zhang, Shan He, Ling Feng, Junyan Han, Wanjiang Zeng, Hui Wang, Yafei Huang   +21 more
wiley   +1 more source