Results 261 to 270 of about 536,771 (324)

Leveraging genetic resources and genomic prediction to enhance flavonol content in cranberry fruit. [PDF]

Plant Genome
Jiménez NP, Fong S, Neyhart JL, Johnson-Cicalese J, Vorsa N, Sideli GM.   +5 more
europepmc   +1 more source

Macrophages Mediate Mesoscale Brain Mechanical Homeostasis

Advanced Materials, EarlyView.
We investigated the role of infiltrating immune cells in sculpting the developing brain. Using Brillouin microscopy and active microrheology, we found microglia actively maintain tissue viscoelasticity. Moreover, colony stimulating factor one receptor (CSF1R)‐driven stromal remodeling alters brain mechanics in vivo. These findings link immune activity,
Woong Young So, Bailey Johnson, Patricia B. Gordon, Kevin S. Bishop, Hyeyeon Gong, Hannah A Burr, Jack Rory Staunton, Chenchen Handler, Khanh Loan Ly, Raman Sood, Giuliano Scarcelli, Kandice Tanner   +11 more
wiley   +1 more source

Assessment of genomic prediction capabilities of transcriptome data in a barley multi-parent RIL population. [PDF]

Theor Appl Genet
Arlt C, van Inghelandt D, Li J, Stich B.
europepmc   +1 more source

Structural Characterization and AI‐Enhanced Modeling of a Broadly Neutralizing Camelid Antibody Against SARS‐CoV‐2 Variants

Advanced Therapeutics, EarlyView.
This study characterizes a camelid antibody (B10) with potent neutralizing activity against SARS‐CoV‐2 Wildtype and Omicron variants. Through binding assays, epitope mapping, pseudovirus neutralization, and AI‐driven modeling, the antibody is shown to target conserved RBD regions in a closed Spike conformation.
Katja Hanack, Urszula Orzeł, Anja Schlör, Sourabh Mehta, Anandi Krishnan, Slawomir Filipek, Rushika Patel, Madhvi Joshi, Markus Hoffmann, Stefan Pöhlmann, Chaitanya Joshi, Dorian Liepmann, Ramasamy Paulmurugan, Venkatesan Renugopalakrishnan   +13 more
wiley   +1 more source

Improved genomic prediction performance with ensembles of diverse models. [PDF]

G3 (Bethesda)
Tomura S, Wilkinson MJ, Cooper M, Powell O.   +3 more
europepmc   +1 more source

Predictive Ability of Statistical Genomic Prediction Methods When Underlying Genetic Architecture of Trait Is Purely Additive [PDF]

, 2016
Mehdi Momen, Ahmad Ayatollahi Mehrgardi, A. Sheikhy, Ali Esmailizadeh, M. Assadi Foozi   +4 more
openalex  

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

Disentangling soybean GxE effects in an integrated genomic prediction and machine learning-GWAS workflow. [PDF]

Plant Methods
Verbrigghe N, Muylle H, Pegard M, Rietman H, Đorđević V, Ćeran M, Roldán-Ruiz I.   +6 more
europepmc   +1 more source

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Transferability of genomic prediction models across market segments in potato and the effect of selection. [PDF]

Theor Appl Genet
Thelen K, Wu PY, Baig N, Prigge V, Bruckmüller J, Muders K, Truberg B, Hartje S, Renner J, Van Inghelandt D, Stich B.   +10 more
europepmc   +1 more source