Results 271 to 280 of about 333,629 (311)
Some of the next articles are maybe not open access.
2010
Advances in the biological characterization of tumors has led to the design and development of anticancer agents targeting specific molecular alterations. The majority of these agents are designed to silence phosphorylation signals that are required for the development and maintenance of the cancer phenotype in specific tumor types.
Rakesh, Kumar, Rafael G, Amado
openaire +2 more sources
Advances in the biological characterization of tumors has led to the design and development of anticancer agents targeting specific molecular alterations. The majority of these agents are designed to silence phosphorylation signals that are required for the development and maintenance of the cancer phenotype in specific tumor types.
Rakesh, Kumar, Rafael G, Amado
openaire +2 more sources
Genomics and the prediction of xenobiotic toxicity
Toxicology, 2002The systematic identification and functional analysis of human genes is revolutionizing the study of disease processes and the development and rational use of drugs. It increasingly enables medicine to make reliable assessments of the individual risk to acquire a particular disease, raises the number and specificity of drug targets and explains ...
Urs-A, Meyer, Josef, Gut
openaire +2 more sources
[Prediction of transcription and genomic sequences].
Medecine sciences : M/S, 2004Technological developments have enhanced DNA sequencing at genomic scale. On the basis of the resulting sequences, computational biologists now attempt to localise the most important functional regions, starting with genes, but also importantly the regulatory motifs and conditions controlling their expression.
Martin, David +2 more
openaire +3 more sources
Evaluation of Predictive Genomic Applications
2020The last fifteen years have seen the emergence of Public Health Genomics (PHG), a multidisciplinary field related to the effective and responsible translation of genome-based knowledge and technologies to improve population health. While at the beginning the main concern of PHG was that genetic/genomic applications should be evaluated rigorously before
Villari P. +3 more
openaire +2 more sources
Predicting structures for genome proteins
Current Opinion in Structural Biology, 1999Assigning three-dimensional protein folds to genome sequences is essential to understanding protein function. Although experimental three-dimensional structures are currently available for only a very small fraction of these sequences, computational fold assignment is able to assign folds to 20-30% of the sequences in various genomes.
D, Fischer, D, Eisenberg
openaire +2 more sources
Exon prediction in eucaryotic genomes
Biochimie, 1996Two independent computer systems, NetPlantGene and AMELIE, dedicated to the identification of splice sites in plant and human genomes, respectively, are introduced here. Both methods were designed in relation to experimental work; they rely on automatically generated rules involving the nucleotide content of sequences regardless of the coding ...
Vignal, L. +6 more
openaire +3 more sources
2020
Genomic prediction is transforming animal and plant breeding and its utility to predict human disease risk is being explored. The method aims to predict an individual’s future phenotype based on only a DNA test. This lecture will introduce genomic prediction, including the basic concepts, main statistical models, validation strategies, and method ...
openaire +1 more source
Genomic prediction is transforming animal and plant breeding and its utility to predict human disease risk is being explored. The method aims to predict an individual’s future phenotype based on only a DNA test. This lecture will introduce genomic prediction, including the basic concepts, main statistical models, validation strategies, and method ...
openaire +1 more source
Fold Predictions for Bacterial Genomes
Journal of Structural Biology, 2001Fold assignments for newly sequenced genomes belong to the most important and interesting applications of the booming field of protein structure prediction. We present a brief survey and a discussion of such assignments completed to date, using as an example several fold assignment projects for proteins from the Escherichia coli genome.
K, Pawlowski +3 more
openaire +2 more sources
SIFT missense predictions for genomes
Nature Protocols, 2015The SIFT (sorting intolerant from tolerant) algorithm helps bridge the gap between mutations and phenotypic variations by predicting whether an amino acid substitution is deleterious. SIFT has been used in disease, mutation and genetic studies, and a protocol for its use has been previously published with Nature Protocols.
Robert Vaser +4 more
openaire +2 more sources
Operon Prediction in Bacterial Genomes
2008Operons are sets of adjacent genes that encode proteins with related metabolic functions. Operon prediction may be useful for understanding the systems of regulation and for genome annotation. In this work, we present an extension of the PROCSIMO tool to allow the operon prediction in bacterial genomes based on the similarity evaluation between pairs ...
Matheus B. S. Barros +2 more
openaire +1 more source