Results 181 to 190 of about 4,045,535 (372)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Hydrophobic bile acids, genomic instability, Darwinian selection, and colon carcinogenesis

Clinical and Experimental Gastroenterology, 2008
Claire M Payne, Carol Bernstein, Katerina Dvorak, Harris BernsteinDepartment of Cell Biology and Anatomy, College of Medicine, University of Arizona, Tucson, Arizona, USAAbstract: Sporadic colon cancer is caused predominantly by dietary factors.
Claire M Payne, Carol Bernstein, Katerina Dvorak, Harris Bernstein   +3 more
doaj  

Signatures of positive selection after the introduction of genomic selection in the Finnish Ayrshire population

Journal of Dairy Science
: The Finnish Ayrshire (FAY) belongs to the Nordic Red breeds and is characterized by high milk yield, high milk components, good fertility, and functional conformation. The FAY breeding program is based on genomic selection.
Katri Sarviaho, Pekka Uimari, Katja Martikainen   +2 more
doaj   +1 more source

Genomic selection in white lupin [PDF]

, 2019
Genomic selection in white ...
Annicchiarico, Paolo, Ferrari, Barbara, Nazzicari, Nelson   +2 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Efficiency of Genomic Selection for Developing Superior Pure Lines

Agronomy
The objectives were to assess the efficacy of genomic selection in pure line breeding, using a simulated dataset, the significance of several factors, including model updating, selection intensity, early generation (F2) selection, dominance, and the ...
Jean Paulo Aparecido da Silva, José Marcelo Soriano Viana   +1 more
doaj   +1 more source

Simulations of genomic selection accuracy and model updating across multiple breeding strategy scenarios in common bean [PDF]

, 2022
Isabella Chiaravalotti, Jennifer Lin, Vivi N. Arief, Zulfi Jahufer, Juan M. Osorno, Phillip E. McClean, Diego Jarquín, Valerio Hoyos‐Villegas   +7 more
openalex   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Accuracy of genomic selection in a rice synthetic population developed for recurrent selection. [PDF]

, 2013
Genomic selection is a promising breeding strategy for rapid improvement of complex traits. We investigated the accuracy of genomic estimate breeding values (GEBV) through cross validation in a synthetic population (SP) of broad genetic diversity ...
Ahmadi, Nourollah, Cao-Hamadou, Tuong-Vi, Courtois, Brigitte, Grenier, Cécile, Ospina, Yolima, Tohmé, Joe   +5 more
core  

Genomic selection: A breakthrough technology in rice breeding

Crop Journal, 2021
Yang Xu, Ke Ma, Yue Zhao, Xin Wang, Kai Zhou, Guang-wei Yu, Cheng Li, Pengcheng Li, Zefeng Yang, Chenwu Xu, Shizhong Xu   +10 more
semanticscholar   +1 more source