Results 261 to 270 of about 3,983,457 (419)

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Genomic selection of maize test-cross hybrids leveraged by marker sampling. [PDF]

Plant Genome
Bernardeli A, Guilhen JHS, Oliveira ICM, Guimarães LJM, Borém A, Jarquin D, Pastina MM.   +6 more
europepmc   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Rapid cycling genomic selection in maize landraces. [PDF]

Theor Appl Genet
Polzer C, Auinger HJ, Terán-Pineda M, Hölker AC, Mayer M, Presterl T, Rivera-Poulsen C, da Silva S, Ouzunova M, Melchinger AE, Schön CC.   +10 more
europepmc   +1 more source

Feature Selection for Genomic and Proteomic Data Mining [PDF]

, 2008
Sun‐Yuan Kung, Man‐Wai Mak
openalex   +1 more source

CINs of the cytoplasm: dissecting dsRNA signaling in chromosomal instability

Molecular Oncology, EarlyView.
Micronuclei, formed during cell division in chromosomal instability settings, rupture and lead to the accumulation of immunogenic double‐stranded RNA in the cytoplasm, activating MAVS‐dependent interferon signaling and innate antitumor immunity.
Aglaia Skolariki, Rose L. Jady‐Clark, Eileen E. Parkes   +2 more
wiley   +1 more source

Assessing the utility of genomic selection to breed for durable Ascochyta blight resistance in chickpea. [PDF]

Plant Genome
Lin Z, Li Y, Riaz A, Sudheesh S, Yazdifar S, Atieno J, Blake S, Croser J, Fanning J, Hayden MJ, Kaur S.   +10 more
europepmc   +1 more source

Divergent selection and heterogeneous genomic divergence [PDF]

, 2009
Patrik Nosil, Daniel J. Funk, Daniel Ortiz‐Barrientos   +2 more
openalex   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Environmental genomic selection to leverage polygenic local adaptation in barley landraces. [PDF]

Commun Biol
Halpin-McCormick A, Campbell Q, Negrão S, Morrell PL, Hübner S, Neyhart JL, Kantar MB.   +6 more
europepmc   +1 more source