Results 31 to 40 of about 3,072,702 (307)

Platinum and PARP Inhibitor Resistance Due to Overexpression of MicroRNA-622 in BRCA1-Mutant Ovarian Cancer

Cell Reports, 2016
High-grade serous ovarian carcinomas (HGSOCs) with BRCA1/2 mutations exhibit improved outcome and sensitivity to double-strand DNA break (DSB)-inducing agents (i.e., platinum and poly(ADP-ribose) polymerase inhibitors [PARPis]) due to an underlying ...
Young Eun Choi, Khyati Meghani, Marie-Eve Brault, Lucas Leclerc, Yizhou J. He, Tovah A. Day, Kevin M. Elias, Ronny Drapkin, David M. Weinstock, Fanny Dao, Karin K. Shih, Ursula Matulonis, Douglas A. Levine, Panagiotis A. Konstantinopoulos, Dipanjan Chowdhury   +14 more
doaj   +1 more source

CUL4A ubiquitin ligase: a promising drug target for cancer and other human diseases [PDF]

Open Biology, 2014
The ability of cullin 4A (CUL4A), a scaffold protein, to recruit a repertoire of substrate adaptors allows it to assemble into distinct E3 ligase complexes to mediate turnover of key regulatory proteins.
Puneet Sharma, Alo Nag
doaj   +1 more source

STUbLs in chromatin and genome stability [PDF]

Biopolymers, 2012
AbstractChromatin structure and function is based on the dynamic interactions between nucleosomes and chromatin‐associated proteins. In addition to the other post‐translational modifications considered in this review issue of Biopolymers, ubiquitin and SUMO proteins also have prominent roles in chromatin function.
Renee, Garza, Lorraine, Pillus
openaire   +2 more sources

Potential Roles of PTEN on Longevity in Two Closely Related Argopecten Scallops With Distinct Lifespans

Frontiers in Physiology, 2022
Phosphatase and tensin homolog deleted on chromosome ten (PTEN) has been found to regulate longevity through the PI3K/Akt/FoxO pathway and maintenance of genome integrity in worms, flies, and mammals.
Hanzhi Xu, Xia Lu, Chunde Wang, Chunde Wang, Junhao Ning, Min Chen, Yuan Wang, Yuan Wang, Ke Yuan, Ke Yuan   +9 more
doaj   +1 more source

Sequencing data: A genomic network to monitor Earth

, 2012
We propose that a network of genomic observatories should be established to take the planet's 'biological pulse'. We invite participants to assist in the shaping of this network (see genomicobservatories.org).
Field, D., The Genomic Observatories Network, Neil Davies, Hirsch, P. R., The Genomic Observatories Network, ., The Genomic Observatories Network,, Davies, N., Field, Dawn, Bates, N., Dawn Field, Davies, Neil   +10 more
core   +1 more source

Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis

eLife, 2015
NCOA4 is a selective cargo receptor for the autophagic turnover of ferritin, a process critical for regulation of intracellular iron bioavailability. However, how ferritinophagy flux is controlled and the roles of NCOA4 in iron-dependent processes are ...
Joseph D Mancias, Laura Pontano Vaites, Sahar Nissim, Douglas E Biancur, Andrew J Kim, Xiaoxu Wang, Yu Liu, Wolfram Goessling, Alec C Kimmelman, J Wade Harper   +9 more
doaj   +1 more source

A quantitative account of genomic island acquisitions in prokaryotes [PDF]

, 2011
Background Microbial genomes do not merely evolve through the slow accumulation of mutations, but also, and often more dramatically, by taking up new DNA in a process called horizontal gene transfer.
van Passel, Mark W. J., van Passel Mark WJ, Passel, M.W.J., van, Mark WJ van Passel, Roos Tom E, Roos, T.E., van Passel, M.W.J., Roos, Tom E., Tom E Roos   +8 more
core   +3 more sources

ARID1A mutation and genomic stability [PDF]

Molecular & Cellular Oncology, 2020
We have recently discovered that AT-rich interactive domain-containing protein 1A (ARID1A) protects telomere cohesion through regulation of the cohesin subunit stromal antigen 1 (STAG1). ARID1A inactivation results in mitotic defects and negatively selects gross chromosomal aberrations, resulting in preservation of genomic stability in ARID1A-mutated ...
Timothy Nacarelli, Bo Zhao, Xue Hao, Rugang Zhang   +3 more
openaire   +3 more sources

A unified mechanism for PARP inhibitor-induced PARP1 chromatin retention at DNA damage sites in living cells

Cell Reports
Summary: Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) not only suppress PARP1 catalytic activity but also prolong its association to damaged chromatin.
Petar-Bogomil Kanev, Sylvia Varhoshkova, Irina Georgieva, Maria Lukarska, Dilyana Kirova, Georgi Danovski, Stoyno Stoynov, Radoslav Aleksandrov   +7 more
doaj   +1 more source

Genome Stability Requires p53 [PDF]

Cold Spring Harbor Perspectives in Medicine, 2016
It is now clear that functional p53 is critical to protect the genome from alterations that lead to tumorigenesis. However, with the myriad of cellular stresses and pathways linked to p53 activation, much remains unknown about how p53 maintains genome stability and the proteins involved. The current understanding of the multiple ways p53 contributes to
openaire   +2 more sources