Results 11 to 20 of about 3,072,702 (307)
HSP70 and Genomic Stability [PDF]
Cell Cycle, 2004 The 70 kDa heat shock proteins (HSP70s) were initially identified by their elevated expression following hyperthermic cell stress, however, these highly conserved proteins also protect critical cellular functions from a wider range of important environmental and physiological stresses.Tej K, Pandita, Ryuji, Higashikubo, Clayton R, Hunt +2 moreopenaire +2 more sourcesSIRT7: a sentinel of genome stability [PDF]
Open Biology, 2021 SIRT7 is a class III histone deacetylase that belongs to the sirtuin family. The past two decades have seen numerous breakthroughs in terms of understanding SIRT7 biological function. We now know that this enzyme is involved in diverse cellular processes, ranging from gene regulation to genome stability, ageing and tumorigenesis. Genomic instability is Ming Tang, Huangqi Tang, Bo Tu, Wei-Guo Zhu +3 moreopenaire +3 more sourcesDiploid-specific genome stability genes of S. cerevisiae: genomic screen reveals haploidization as an escape from persisting DNA rearrangement stress. [PDF]
, 2011 Maintaining a stable genome is one of the most important tasks of every living cell and the mechanisms ensuring it are similar in all of them. The events leading to changes in DNA sequence (mutations) in diploid cells occur one to two orders of magnitude Skoneczna, Adrianna, Malgorzata Alabrudzinska, Marek Skoneczny, Alabrudzinska Malgorzata, Skoneczna Adrianna, Skoneczny Marek, Alabrudzinska, Malgorzata, Skoneczny, Marek, Adrianna Skoneczna +8 morecore +3 more sourcesHypoxia stabilizes SETDB1 to maintain genome stability
Nucleic Acids Research, 2023 Abstract Von Hippel–Lindau (VHL) is a tumor suppressor that functions as the substrate recognition subunit of the CRL2VHL E3 complex. While substrates of VHL have been identified, its tumor suppressive role remains to be fully understood.Sungryul Park, Jin Hwa Cho, Jong-Hwan Kim, Mijin Park, Seulki Park, Seon-Young Kim, Seon-Kyu Kim, Kidae Kim, Sung Goo Park, Byoung Chul Park, Jeong Hee Moon, Gaseul Lee, Sunhong Kim, Jung-Ae Kim, Jeong-Hoon Kim +14 moreopenaire +2 more sourcesMaintenance of Genome Stability
Genomics, Proteomics & Bioinformatics, 2016 It was ever thought that genomic information is transmitted faithfully from generation to generation. But our current knowledge does not indicate that it is the case. For example, genomic variations can be generated from DNA replication infidelity and unequal chromosome segregation.Jiadong Wang, Tomas Lindahlopenaire +4 more sourcesThe founding charter of the Genomic Observatories Network [PDF]
, 2014 The co-authors of this paper hereby state their intention to work together to launch the Genomic Observatories Network (GOs Network) for which this document will serve as its Founding Charter.Leong, Jo Ann, Clark, M., Gloeckner, Frank Oliver, Gerdts, G., Coddington, Jonathan, Yuri P Springer, Naiara Rodriguez-Ezpeleta, Springer, Yuri P., Karsten Schonrogge, Bietz, Matthew J, Angel Borja, Marteinsson, Viggo Thor, Penny R Hirsch, Clark, M. S., Scholin, C., Wooley, J. C., Wooley, J., Meyer, C., Tetsukazu Yahara, Scholan, Chris, Patricia Wecker, Nathalie Simon, Hanson, Paul C., Koo, M. S., D. Myrold, David, Gates, R. D., null null, GOs-COS, Leong, J-A., Amaral-Zettler, L., Jean-Marc Hero, Meyer, Folker, Antje Wichels, Fuhrman, J., Jonathan Coddington, Scholin, Chris, Drummond, Alexei, Marteinsson, Viggó, Gerdts, Gunnar, Hero, J., Glöckner, Frank, Simon, Nathalie, Kotoulas, Gergios, Paul C Hanson, Vogler, Alfried P., Stone, G., Stones-Havas, Steve, Knight, R., Levente Bodrossy, Hirsch, Penny R., Véronique Berteaux-Lecellier, Vogler, A., Deck, J., Linda Amaral-Zettler, Field, D., Geller, J., Neil Davies, Alfried P Vogler, Schonrogge, K., Lowe, Andrew J., Wooley, John C., Polymenakou, P., Steve Stones-Havas, John C Wooley, Zingone, Adriana, co-authors, 6 7, Barbier, M., Morrison, N., Ratnasingham, Sujeevan, Field, Dawn, Bertilsson, S., Vogler, Alfried P, Barbier, Michèle, Wichels, Antje, Kate M Thibault, Gillespie, Rosemary, Marteinsson, V., Hanson, P., Bodrossy, Levente, Drummond, A., Valette-Silver, Nathalie J, Serge Planes, Ratnasingham, S., Barker, K., ?, ?, Bertilsson, Stefan, Stone, Graham N., Anna Klindworth, Jeanthon, C., Sansone, S., Springer, Y. P., Planes, Serge, Parnell, J., Chris Meyer, Hanson, P. C., Matthias Obst, Michelle S Koo, Jeanthon, Christian, Alexei Drummond, Leong, Jo-Ann, Glockner, F. O., Jansson, Janet, Myrold, David D., Jansson, Janet, K., Stone, Graham N, Sansone, Susanna-Assunta, Lowe, A., Parnell, John, Glöckner, F., Obst, M., Thibault, K. M., Barker, Katherine, Kao, R., Marteinsson, V. T., Hirsch, Penny, Thibault, Kate M., Koo, M., Davies, Neil, Sujeevan Ratnasingham, Hirsch, P., Rosemary Gillespie, Wecker, Patricia, Polymenakou, Paraskevi N, Gilbert, J., Vogler, A. P., Simon, N., Myrold, D., Faith, D., Koo, Michelle S, Gates, Ruth D., Paraskevi N Polymenakou, Andrew J Lowe, Yahara, T., Kelly Goodwin, Clark, Melody S, Jack Gilbert, Parker, Stefanie, Rodriguez- Ezpeleta, Naiara, Rodriguez-Ezpeleta, Naiara, Borja, A., Hirsch, Penny R, Clark, Melody S., Knight, Rob, George K Roderick, Yahara, Tetsukazu, Norman Morrison, Roderick, George K, John Deck, David Hoekman, Faith, Daniel P, Stephanie Parker, Gates, R., Hanson, Paul C, Fuhrman, Jed, Toonen, R., Berteaux-Lecellier, Véronique, Parnell, Jacob J., Wichels, A., Drummond, Alexei J., Meyer, Chris, Rebecca Kao, Kottmann, Renzo, Goodwin, K., Zingone, A., Wecker, P., Jason Bobe, Bobe, Jason, Gunnar Gerdts, Planes, S., Leong, J., Jansson, J., John Jacob Parnell, Hero, Jean-Marc, Katherine Barker, Roderick, G. K., Graham N Stone, Hero, J-M., Jed Fuhrman, Susanna-Assunta Sansone, Bietz, M., Pafilis, Evangelos, Renzo Kottmann, Morrison, Norman, Wooley, John C, Parker, Stephanie, Dawn Field, Deck, John, Roderick, G., Springer, Yuri P, Rob Toonen, Matthew J Bietz, Myrold, D. D., Parker, S., Berteaux-Lecellier, V., Hoekman, David, Valette-Silver, N., Ruth D Gates, Bicak, M., Hoekman, D., Geller, Jonathan, Christian Jeanthon, Polymenakou, P. N., Sansone, S-A., Lowe, Andrew J, Kotoulas, Georgios, Amaral-Zettler, Linda, Glöckner, Frank Oliver, Springer, Y., Georgios Kotoulas, Janet Jansson, Folker Meyer, Borja, Angel, Faith, Daniel P., Kottmann, R., Schonrogge, Karsten, Springer, Yuri, Obst, Matthias, Michèle Barbier, Nathalie J Valette-Silver, Bietz, Matthew J., Roderick, George K., Bietz, M. J., Goodwin, Kelly, Stefan Bertilsson, Gillespie, R., Valette-Silver, N. J., Polymenakou, Paraskevi N., Parnell, J. J., Bobe, J., Meyer, F., Jonathan Geller, Davies, N., Stone, G. N., Bicak, Mesude, Frank Oliver Glöckner, David D Myrold, Coddington, J., Gilbert, Jack, Chris Scholin, Rodriguez-Ezpeleta, N., Myrold, David D, Thibault, Kate M, Melody S Clark, Gos-Cos, Gos-Cos, Stones-Havas, S., Evangelos Pafilis, Gates, Ruth D, Klindworth, Anna, Klindworth, A., Jo-Ann Leong, Pafilis, E., Kotoulas, G., Hirsch, P. R., Koo, Michelle S., Viggó Thór Marteinsson, Mesude Bicak, Jansson, Janet,, Faith, D. P., Adriana Zingone, Rob Knight, Bodrossy, L., Thibault, K., Daniel P Faith, Toonen, Rob, Valette-Silver, Nathalie J., Kao, Rebecca, Parnell, John Jacob +266 morecore +2 more sourcesSIRT1 Prevents R-Loops during Chronological Aging by Modulating DNA Replication at rDNA Loci
Cells, 2023 In metazoans, the largest sirtuin, SIRT1, is a nuclear protein implicated in epigenetic modifications, circadian signaling, DNA recombination, replication, and repair.Bhushan L. Thakur, Nana A. Kusi, Sara Mosavarpour, Roger Zhu, Christophe E. Redon, Haiqing Fu, Anjali Dhall, Lorinc S. Pongor, Robin Sebastian, Fred E. Indig, Mirit I. Aladjem +10 moredoaj +1 more sourceKu and the Stability of the Genome [PDF]
BioMed Research International, 2002 Ku proteins are associated with a variety of cellular processes such as repair of DNA‐double‐strand breaks, telomere maintenance and retrotransposition. In recent years, we have learned a lot about their cellular and molecular functions and it has turned out that Ku‐dependent processes affect the stability of the genome, both positively and negatively, openaire +2 more sourcesCaloric restriction and genomic stability [PDF]
Nucleic Acids Research, 2007 Caloric restriction (CR) reduces the incidence and progression of spontaneous and induced tumors in laboratory rodents while increasing mean and maximum life spans. It has been suggested that CR extends longevity and reduces age-related pathologies by reducing the levels of DNA damage and mutations that accumulate with age.Heydari, Ahmad R., Unnikrishnan, Archana, Lucente, Lisa Ventrella, Richardson, Arlan +3 moreopenaire +2 more sources
