Results 1 to 10 of about 3,072,702 (307)

Transposons disrupt genomic stability and trigger cancers [PDF]

Frontiers in Cellular and Infection Microbiology
Transposons (TEs) are genetic elements that can change their positions within genome. They cause transcriptional activation or repression by inserting into regulatory elements of related genes or by modulating epigenetic modifications on regulatory ...
Weixia Dong, Menghui Li, Ping Li, Xiaoli Hou, Fei He, Shaoping Ji, Shaoping Ji, Shaoping Ji   +7 more
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The Effect of Dia2 Protein Deficiency on the Cell Cycle, Cell Size, and Recruitment of Ctf4 Protein in Saccharomyces cerevisiae

Molecules, 2021
Cells have evolved elaborate mechanisms to regulate DNA replication machinery and cell cycles in response to DNA damage and replication stress in order to prevent genomic instability and cancer. The E3 ubiquitin ligase SCFDia2 in S.
Aneliya Ivanova, Aleksandar Atemin, Sonya Uzunova, Georgi Danovski, Radoslav Aleksandrov, Stoyno Stoynov, Marina Nedelcheva-Veleva   +6 more
doaj   +1 more source

DNArepairK: An Interactive Database for Exploring the Impact of Anticancer Drugs onto the Dynamics of DNA Repair Proteins

Biomedicines, 2021
Cells are constantly exposed to numerous mutagens that produce diverse types of DNA lesions. Eukaryotic cells have evolved an impressive array of DNA repair mechanisms that are able to detect and repair these lesions, thus preventing genomic instability.
Yordan Babukov, Radoslav Aleksandrov, Aneliya Ivanova, Aleksandar Atemin, Stoyno Stoynov   +4 more
doaj   +1 more source

Stem Cell-Based Therapeutic Strategies for Premature Ovarian Insufficiency and Infertility: A Focus on Aging

Cells, 2022
Reproductive aging is on the rise globally and inseparable from the entire aging process. An extreme form of reproductive aging is premature ovarian insufficiency (POI), which to date has mostly been of idiopathic etiology, thus hampering further ...
Ilyas Ali, Arshad Ahmed Padhiar, Ting Wang, Liangge He, Mingzhuang Chen, Shengda Wu, Yan Zhou, Guangqian Zhou   +7 more
doaj   +1 more source

Integrative Analysis of Machine Learning and Molecule Docking Simulations for Ischemic Stroke Diagnosis and Therapy

Molecules, 2023
Due to the narrow therapeutic window and high mortality of ischemic stroke, it is of great significance to investigate its diagnosis and therapy. We employed weighted gene coexpression network analysis (WGCNA) to ascertain gene modules related to stroke ...
Jingwei Song, Syed Aqib Ali Zaidi, Liangge He, Shuai Zhang, Guangqian Zhou   +4 more
doaj   +1 more source

Rothmund-Thomson syndrome, a disorder far from solved

Frontiers in Aging, 2023
Rothmund-Thomson syndrome (RTS) is a rare autosomal recessive disorder characterized by a range of clinical symptoms, including poikiloderma, juvenile cataracts, short stature, sparse hair, eyebrows/eyelashes, nail dysplasia, and skeletal abnormalities ...
Davi Jardim Martins, Ricardo Di Lazzaro Filho, Ricardo Di Lazzaro Filho, Debora Romeo Bertola, Debora Romeo Bertola, Nícolas Carlos Hoch   +5 more
doaj   +1 more source

Autologous Platelet Rich Plasma (PRGF) Preserves Genomic Stability of Gingival Fibroblasts and Alveolar Osteoblasts after Long-Term Cell Culture

Dentistry Journal, 2022
Plasma rich in growth factors (PRGF) has several applications in dentistry that may require repeated applications of PRGF. Furthermore, it has been used for ex vivo expansion of human origin cells for their clinical application.
Eduardo Anitua, María de la Fuente, María Troya, Mar Zalduendo, Mohammad Hamdan Alkhraisat   +4 more
doaj   +1 more source

Mitotic and DNA Damage Response Proteins: Maintaining the Genome Stability and Working for the Common Good

Frontiers in Cell and Developmental Biology, 2021
Cellular function is highly dependent on genomic stability, which is mainly ensured by two cellular mechanisms: the DNA damage response (DDR) and the Spindle Assembly Checkpoint (SAC). The former provides the repair of damaged DNA, and the latter ensures
Fernando Luna-Maldonado, Marco A. Andonegui-Elguera, José Díaz-Chávez, Luis A. Herrera, Luis A. Herrera   +4 more
doaj   +1 more source

Regulation of Redox Profile and Genomic Instability by Physical Exercise Contributes to Neuroprotection in Mice with Experimental Glioblastoma

Antioxidants, 2023
Glioblastoma (GBM) is an aggressive, common brain cancer known to disrupt redox biology, affecting behavior and DNA integrity. Past research remains inconclusive.
Luis F. B. Marqueze, Amanda K. Costa, Giulia S. Pedroso, Franciane F. Vasconcellos, Bruna I. Pilger, Schellen Kindermann, Vanessa M. Andrade, Ana C. B. Alves, Tatyana Nery, Aderbal A. Silva, Stephanie R. S. Carvalhal, Matheus F. Zazula, Katya Naliwaiko, Luiz C. Fernandes, Zsolt Radak, Ricardo A. Pinho   +15 more
doaj   +1 more source

SFPQ and NONO suppress RNA:DNA-hybrid-related telomere instability

Nature Communications, 2019
LncRNA TERRA forms RNA-DNA hybrids at telomere sites leading to telomere instability. Here the authors identify the RNA interacting factors NONO and SFPQ as proteins that interact with TERRA and telomere chromatin and reveal putative roles for these ...
Eleonora Petti, Valentina Buemi, Antonina Zappone, Odessa Schillaci, Pamela Veneziano Broccia, Roberto Dinami, Silvia Matteoni, Roberta Benetti, Stefan Schoeftner   +8 more
doaj   +1 more source