Results 51 to 60 of about 358,877 (267)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Discovery and population genomics of structural variation in a songbird genus
Nature Communications, 2020 Structural genomic variation can fuel evolution. Here, authors present genome data from seven Corvus species and unearth structural variants that vary between incipient crow species in Europe, with implications for premating isolation involving plumage ...
Matthias H. Weissensteiner +11 more
doaj +1 more source
The Plant Genome, 2021 Positional‐based cloning is a foundational method for understanding the genes and gene networks that control valuable agronomic traits such as grain yield components.
Ella Taagen +3 more
doaj +1 more source
Biological Significance of the Genomic Variation and Structural Dynamics of SARS-CoV-2 B.1.617
Frontiers in Microbiology, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have been emerging and circulating globally since the start of the COVID-19 pandemic, of which B.1.617 lineage that was first reported in India at the end of 2020, soon became ...
Lin-qian Fan +7 more
doaj +1 more source
The elusive evidence for chromothripsis. [PDF]
, 2014 The chromothripsis hypothesis suggests an extraordinary one-step catastrophic genomic event allowing a chromosome to 'shatter into many pieces' and reassemble into a functioning chromosome.
Bafna, Vineet +2 more
core +1 more source
Identification of structural variation in mouse genomes [PDF]
Frontiers in Genetics, 2014 Structural variation is variation in structure of DNA regions affecting DNA sequence length and/or orientation. It generally includes deletions, insertions, copy-number gains, inversions, and transposable elements. Traditionally, the identification of structural variation in genomes has been challenging.
Keane, Thomas +5 more
openaire +6 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Evolutionary biology for the 21st century [PDF]
, 2013 New theoretical and conceptual frameworks are required for evolutionary biology to capitalize on the wealth of data now becoming available from the study of genomes, phenotypes, and organisms - including humans - in their natural environments.Molecular ...
Arnold, Stevan J. +14 more
core +5 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Cell GenomicsSummary: The NPIP gene family is among the most positively selected gene families in humans/apes and drives independent duplication in primate lineages.
Philip C. Dishuck +8 more
doaj +1 more source