Results 81 to 90 of about 358,877 (267)

LoRTE: Detecting transposon-induced genomic variants using low coverage PacBio long read sequences

Mobile DNA, 2017
Background Population genomic analysis of transposable elements has greatly benefited from recent advances of sequencing technologies. However, the short size of the reads and the propensity of transposable elements to nest in highly repeated regions of ...
Eric Disdero, Jonathan Filée
doaj   +1 more source

Genomics of Divergence along a Continuum of Parapatric Population Differentiation [PDF]

, 2015
MM received funding from the Max Planck innovation funds for this project. PGDF was supported by a Marie Curie European Reintegration Grant (proposal nr 270891). CE was supported by German Science Foundation grants (DFG, EI 841/4-1 and EI 841/6-1)
A Abyzov, A Alexa, A Auton, A Auton, A Keinan, A McKenna, AD Cutter, AR Quinlan, B Charlesworth, BE Deagle, BJ White, BL Browning, C Eizaguirre, C Eizaguirre, Christophe Eizaguirre, CI Wu, D Berner, Erich Bornberg-Bauer, FC Jones, FJJ Chain, Frédéric J. J. Chain, GAT McVean, H Li, H Li, Irene E. Samonte, Jianzhi Zhang, JL Feder, JL Feder, JL Feder, JM Smith, KM Wegner, M Hanikenne, M Kalbe, M Nei, M Roesti, M Roesti, M Roesti, MA DePristo, MAF Noor, Mahesh Panchal, Manfred Milinski, Martin Kalbe, Monika Stoll, MW Nachman, N Barton, N Udpa, O Seehausen, P Danecek, P Flicek, P Nosil, PA Hohenlohe, PA Hohenlohe, PF Colosimo, PGD Feulner, Philine G. D. Feulner, R Kaeuffer, R Waples, S Renaut, S Via, SD McCormick, T Hofer, TE Cruickshank, Thorsten B. H. Reusch, TL Turner, Tobias L. Lenz, V Soria-Carrasco, Yun Huang   +66 more
core   +5 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Optical genome mapping identifies clinically relevant genomic rearrangements in prostate cancer biopsy sample

Cancer Cell International, 2022
Background Prostate cancer (PCa) is characterized by complex genomic rearrangements such as the ETS oncogene family fusions, yet the clinical relevance is not well established.
Yeeun Shim, Jongsoo Lee, Jieun Seo, Cheol Keun Park, Saeam Shin, Hyunho Han, Seung-Tae Lee, Jong Rak Choi, Byung Ha Chung, Young Deuk Choi   +9 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Evolution of genomic structural variation and genomic architecture in the adaptive radiations of African cichlid fishes

Frontiers in Genetics, 2014
African cichlid fishes are an ideal system for studying explosive rates of speciation and the origin of diversity in adaptive radiation. Within the last few million years, more than 2000 species have evolved in the Great Lakes of East Africa, the largest
Shaohua eFan, Axel eMeyer
doaj   +1 more source

ProtocadherinX/Y, a Candidate Gene-Pair for Schizophrenia and Schizoaffective Disorder: A DHPLC Investigation of Gonomic Sequence [PDF]

, 2004
Protocadherin X and Protocadherin Y (PCDHX and PCDHY) are cell-surface adhesion molecules expressed predominantly in the brain. The PCDHX/Y gene-pair was generated by an X-Y translocation approximately 3 million years ago (MYA) that gave rise to the Homo
Crow, Prof TJ, DeLisi, Prof LE, Giouzeli, Ms M, Lonie, Dr LJ, Williams, Dr NA   +4 more
core  

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries. [PDF]

, 2018
Lipoprotein(a), Lp(a), is a modified low-density lipoprotein particle that contains apolipoprotein(a), encoded by LPA, and is a highly heritable, causal risk factor for cardiovascular diseases that varies in concentrations across ancestries. Here, we use
Alver, Maris, Bloom, Jonathan, Budoff, Matthew, Chaffin, Mark, Correa, Adolfo, Cupples, L Adrienne, Daly, Mark J, Engreitz, Jesse, Ernst, Jason, Esko, Tonu, Fu, Mao, Ganna, Andrea, Handsaker, Robert E, Johnson, W Craig, Kathiresan, Sekar, Kellis, Manolis, Manichaikul, Ani, McCarroll, Steven, Metspalu, Andres, Mitchell, Braxton D, Natarajan, Pradeep, Neale, Benjamin M, NHLBI TOPMed Lipids Working Group, Peloso, Gina M, Post, Wendy, Poterba, Timothy, Rich, Stephen S, Ripatti, Samuli, Rotter, Jerome I, Ruotsalainen, Sanni, Ryan, Kathleen A, Salomaa, Veikko, Seed, Cotton, Surakka, Ida, Tsai, Michael, Vasan, Ramachandran S, Wilson, James G, Yang, Chaojie, Zekavat, Seyedeh M   +38 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Genome-wide diversity and gene expression profiling of Babesia microti isolates identify polymorphic genes that mediate host-pathogen interactions [PDF]

, 2016
Babesia microti, a tick-transmitted, intraerythrocytic protozoan parasite circulating mainly among small mammals, is the primary cause of human babesiosis.
Ben Mamoun, Choukri, Brancato, Jana, Chibucos, Marcus, Colinge, Jacques, Cornillot, Emmanuel, Crabtree, Jonathan, Dwivedi, Ankit, Fraser, Claire M., Frutos, Roger, Gotia, Hanzel T., Hung, Chris, Ifeonu, Olukemi O., Krause, Peter J., Kumar, Vidya, Kumari, Priti, Lawres, Lauren, McCracken, Carrie, Molina, Douglas M., Orvis, Joshua, Ott, Sandy, Pablo, Jozelyn V., Pazzi, Joseph E., Reynes, Christelle, Sadzewicz, Lisa, Sengamalay, Naomi, Shetty, Amol C., Silva, Joana C., Su, Qi, Tallon, Luke, Tretina, Kyle, Usmani-Brown, Sahar, Virji, Azan Z.   +31 more
core   +3 more sources