Results 101 to 110 of about 149,760 (296)

Diversity of Pharmaceuticals Enhances Antibiotic Resistance in the Invertebrate Gut via Biofilm‐Mediated Mechanisms

Advanced Science, EarlyView.
Pharmaceutical diversity acts as an independent driver of antibiotic resistance in soil invertebrates. While bulk soil remains unaffected, the collembolan gut microbiome exhibits significant resistance gene enrichment under complex chemical exposure and diurnal warming.
Yi‐Fei Wang, Ya‐Ning Wang, Da Lin, Jia‐Yang Xu, Feng‐Yuan Qi, Hui‐Ling Cui, Hui‐Jie Lu, Min Qiao, Edward Topp, Dong Zhu, Matthias C. Rillig, Yong‐Guan Zhu   +11 more
wiley   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Strengthening pathogen genomic surveillance: the way forward [PDF]

Next-generation sequencing (NGS) technologies were instrumental in the identification and evolutional tracking of SARS-CoV-2 during the COVID-19 pandemic.
Yong, Ang Geik, Zakaria, Zunita, Mat Isa, Nurulfiza, Yee, Yu Choo   +3 more
core  

Genomic and Epidemiologic Surveillance of SARS-CoV-2 in the Pandemic Period: Sequencing Network of the Lazio Region, Italy

, 2023
Since the beginning of the COVID-19 pandemic, large-scale genomic sequencing has immediately pointed out that SARS-CoV-2 has rapidly mutated during the course of the pandemic, resulting in the emergence of variants with a public health impact.
Paola Scognamiglio, Maria Beatrice Valli, Cesare Ernesto Maria Gruber, Enrico Girardi, Fabrizio Maggi, Lavinia Fabeni, Giulia Berno, Maria Valli, Emanuela Giombini, SARS-CoV-2 Lazio Genomic Surveillance Study Group, Francesco Vairo, Cesare Gruber, Alessandro Agresta, Ornella Butera, Martina Spaziante, Martina Rueca, Alessandra Barca   +16 more
core   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Genomic surveillance reveals geographical heterogeneity and differences in known and novel insecticide resistance mechanisms in Anopheles arabiensis across Kenya

BMC Genomics
Background Insecticide resistance in disease vectors poses a significant threat to the control of transmission globally. In Anopheles mosquitoes, resistance has jeopardized gains made in malaria control and led to the resurgence of cases.
Brian Polo, Kelly L. Bennett, Sonia Barasa, Jon Brenas, Silas Agumba, Joseph Mwangangi, Lucy Wachira, Stanley Kitur, Damaris Matoke-Muhia, David M. Mburu, Edith Ramaita, Elijah O. Juma, Charles Mbogo, Eric Ochomo, Chris S. Clarkson, Alistair Miles, Luna Kamau   +16 more
doaj   +1 more source

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

Advanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang, Jiajia Liu, Jianguo Wen, Yangyang Luo, Zhiwei Fan, Liren Yang, Xi Hu, Ruihan Luo, Yankai Yu, Sophia Li, Weiling Zhao, Xiaobo Zhou   +11 more
wiley   +1 more source

Benchmarking of human read removal strategies for viral and microbial metagenomics

Cell Reports: Methods
Summary: Human reads are a key contaminant in microbial metagenomics and enrichment-based studies, requiring removal for computational efficiency, biological analysis, and privacy protection.
Matthew Forbes, Duncan Y.K. Ng, Róisín M. Boggan, Andrea Frick-Kretschmer, Jillian Durham, Oliver Lorenz, Bruhad Dave, Florent Lassalle, Carol Scott, Josef Wagner, Adrianne Lignes, Fernanda Noaves, David K. Jackson, Kevin Howe, Ewan M. Harrison   +14 more
doaj   +1 more source

Haplotype‐Resolved 3D Genomic Landscapes and Their Impacts on Agronomic Traits in Grapevine

Advanced Science, EarlyView.
This study presents a haplotype‐resolved 3D genomic landscape of grapevine, revealing that structural variations (SVs) are closely associated with phased topologically associating domain (TAD) boundary transitions. These rearrangements coordinate with allele‐specific DNA methylation (ASM) and allele‐biased gene expression (ASE) to shape key agronomic ...
Yanling Peng, Lianzhu Zhou, Xinyue Fang, Ruoyan Zhao, Qi Xu, Mengrui Du, Ting Hou, Guizhou Huang, Yingchun Zhang, Sheng Yan, Ruo Yang, Zhongxin Jin, Yang Dong, Yanshuai Xu, Hua Xiao, Xiaodong Xu, Yi Liao, Xiping Wang, Yongfeng Zhou   +18 more
wiley   +1 more source