Results 91 to 100 of about 149,760 (296)

Traveler-based genomic surveillance for SARS-CoV-2 [PDF]

Maps, charts, and data provided by CDC, updates weekly on Friday by 8:00 pm ETLatest week of collection: 2023-05-15Surveillance of international air travelers can provide early detection of new and emerging infectious diseases, including new variants of ...

core   +4 more sources

Disparate co-evolution and prevalence of sulfadoxine and pyrimethamine resistance alleles and haplotypes at dhfr and dhps genes across Africa

Scientific Reports
Sulfadoxine-pyrimethamine (SP), despite emergence of mutations in dhfr and dhps genes associated with lower treatment efficacy, is still recommended for preventive malaria treatment. Therefore, it is important to understand the evolution of P. falciparum
Nina F. D. White, Georgia Whitton, Varanya Wasakul, Lucas Amenga-Etego, Antoine Dara, Voahangy Andrianaranjaka, Milijaona Randrianarivelojosia, Olivo Miotto, Umberto D’Alessandro, Abdoulaye Djimdé, Cristina V. Ariani, Richard D. Pearson, Alfred Amambua-Ngwa   +12 more
doaj   +1 more source

Whole genome enrichment approach for genomic surveillance of Toxoplasma gondii

Food Microbiology
Pathogenic bacteria, viruses, fungi, and protozoa can cause food and waterborne diseases. Surveillance methods must therefore screen for these pathogens at various stages of water distribution and of food from production to consumption. Detection using nucleic acid amplification methods offer rapid identification, but such methods have limited utility ...
Balaji Sundararaman, Karen Shapiro, Andrea Packham, Lauren E. Camp, Rachel S. Meyer, Beth Shapiro, Richard E. Green   +6 more
openaire   +2 more sources

Mesenchymal Stromal Cell‐Mediated Intercellular Communication: Mapping the Interactome for Skeletal Muscle Homeostasis and Regeneration

Advanced Science, EarlyView.
Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu, Edgar E. Perez Carbajal, Yih‐Chii Hwang, Sahil A. Mapkar, Benjamin W. Gilman, Sarah A. Bliss, Lam B. Tran, Kalgi T. Mehta, Jacob O. Banyasz, Ming Yu, Reynold R. Liu, Matthew N. Ly, Christapher S. Morrissey, Michael N. Wosczyna   +13 more
wiley   +1 more source

Profiling the resistome and virulome of Bacillus strains used for probiotic-based sanitation: a multicenter WGS analysis

BMC Genomics
Background Healthcare-associated infections (HAIs) caused by microbes that acquire antimicrobial resistance (AMR) represent an increasing threat to human health worldwide. The high use of chemical disinfectants aimed at reducing the presence of pathogens
Francesca Bini, Irene Soffritti, Maria D’Accolti, Eleonora Mazziga, Julio Diaz Caballero, Sophia David, Silvia Argimon, David M. Aanensen, Antonella Volta, Matteo Bisi, Sante Mazzacane, Elisabetta Caselli   +11 more
doaj   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Genomic insights into the spread and evolution of insecticide resistance variants in Anopheles gambiae s.l. from Burkina Faso

Scientific Reports
The intensive use of insecticide-based control tools has led to the rapid evolution of resistant phenotypes in malaria vector populations. Understanding the evolutionary processes underlying these resistances is essential to inform the development and ...
Mahamadi Kientega, Honorine Kaboré, Grégoire Sawadogo, Tin-Yu J. Hui, Nouhoun Traoré, Abdoul-Azize A. Millogo, Hamidou Maiga, Alistair Miles, Chris S. Clarkson, Abdoulaye Diabaté   +9 more
doaj   +1 more source

AMR Surveillance in Africa: Are We There Yet?

International Journal of Infectious Diseases
Delineating the burden of antimicrobial resistance (AMR), detecting outbreaks due to multidrug resistant-bacteria and monitoring AMR trends for the early warning of emerging/escalating AMR in humans, animals, plants and the environment requires high ...
Prof Sabiha Essack, Sabiha Y. Essack
doaj   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

The prevalences of Salmonella Genomic Island 1 variants in human and animal Salmonella Typhimurium DT104 are distinguishable using a Bayesian approach [PDF]

, 2011
Throughout the 1990s, there was an epidemic of multidrug resistant Salmonella Typhimurium DT104 in both animals and humans in Scotland. The use of antimicrobials in agriculture is often cited as a major source of antimicrobial resistance in pathogenic ...
Matthew J Denwood, Reid, S W J, Derek J Brown, Daniel T Haydon, Mellor Dominic J., Mellor, D J, Louise Matthews, Alison E. Mather, Matthews, L., Reid Stuart W. J., Mather, A E, Haydon, D T, Derek J. Brown, Alison E Mather, John E Coia, Coia John E., Matthews, L, Mather, A.E., Stuart W J Reid, Daniel T. Haydon, Brown, D J, Denwood Matthew J., Haydon, D.T., Coia, J E, Dominic J. Mellor, Brown Derek J., John E. Coia, Coia, J.E., Reid, S.W.J., Matthew J. Denwood, Matthews Louise, Stuart W. J. Reid, Denwood, M.J., Denwood, M J, Mather Alison E., Mellor, D.J., Dominic J Mellor, Haydon Daniel T., Brown, D.J.   +38 more
core   +1 more source