Results 71 to 80 of about 150,001 (296)

Genomic surveillance of dengue virus in Benin

Infection, Genetics and Evolution
Dengue is a widespread viral infection transmitted from mosquitoes to humans, mainly in tropical and subtropical climates. In Benin, only dengue virus (DENV) serotype 2 infection has been previously described in humans. This study aimed to investigate DENV infection and serotypes in suspected patients.Plasma samples from 464 patients attending health ...
Yadouleton, Anges, Nouatin, Odilon, Kissira, Islamiath, Houngbegnon, Parfait, Cottrell, Gilles, Fievet, Nadine, Sohou, Stephane, Butel, Christelle, Serrano, Laetitia, Guichet, Emilande, Vidal, Nicole, Delaporte, Eric, Ayouba, Ahidjo, Peeters, Martine, Massougbodji, Achille   +14 more
openaire   +2 more sources

Optimal capacity sharing for global genomic surveillance

Epidemics, 2023
Recent technological advances and substantial cost reductions have made the genomic surveillance of pathogens during pandemics feasible. Our paper focuses on full genome sequencing as a tool that can serve two goals: the estimation of variant prevalences, and the identification of new variants.
Zsombor Z. Méder, Robert Somogyi
openaire   +4 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Malaria Diagnostics and Surveillance in the Post-Genomic Era [PDF]

Public Health Genomics, 2013
Genome sequences are available for 3 human-infecting malaria parasites, <i>Plasmodium falciparum</i>, <i>P. vivax</i> and <i>P. knowlesi</i>, and population genomics data are available for many endemic regions. This review summarizes how genomic data have been used to develop new, species-specific molecular targets ...
N W, Lucchi, J, Oberstaller, J C, Kissinger, V, Udhayakumar   +3 more
openaire   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Genomic and Epidemiologic Surveillance of SARS-CoV-2 in the Pandemic Period: Sequencing Network of the Lazio Region, Italy [PDF]

, 2023
Since the beginning of the COVID-19 pandemic, large-scale genomic sequencing has immediately pointed out that SARS-CoV-2 has rapidly mutated during the course of the pandemic, resulting in the emergence of variants with a public health impact.
Paola Scognamiglio, Maria Beatrice Valli, Cesare Ernesto Maria Gruber, Enrico Girardi, Fabrizio Maggi, Lavinia Fabeni, Giulia Berno, Maria Valli, Emanuela Giombini, SARS-CoV-2 Lazio Genomic Surveillance Study Group, Francesco Vairo, Cesare Gruber, Alessandro Agresta, Ornella Butera, Martina Spaziante, Martina Rueca, Alessandra Barca   +16 more
core   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Whole-genome sequencing of major malaria vectors reveals the evolution of new insecticide resistance variants in a longitudinal study in Burkina Faso

Malaria Journal
Background Intensive deployment of insecticide based malaria vector control tools resulted in the rapid evolution of phenotypes resistant to these chemicals.
Mahamadi Kientega, Chris S. Clarkson, Nouhoun Traoré, Tin-Yu J. Hui, Samantha O’Loughlin, Abdoul-Azize Millogo, Patric Stephane Epopa, Franck A. Yao, Adrien M. G. Belem, Jon Brenas, Alistair Miles, Austin Burt, Abdoulaye Diabaté   +12 more
doaj   +1 more source