Results 61 to 70 of about 1,200,488 (250)

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Advanced Functional Materials, EarlyView.
Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang   +16 more
wiley   +1 more source

Profiling the resistome and virulome of Bacillus strains used for probiotic-based sanitation: a multicenter WGS analysis

BMC Genomics
Background Healthcare-associated infections (HAIs) caused by microbes that acquire antimicrobial resistance (AMR) represent an increasing threat to human health worldwide. The high use of chemical disinfectants aimed at reducing the presence of pathogens
Francesca Bini, Irene Soffritti, Maria D’Accolti, Eleonora Mazziga, Julio Diaz Caballero, Sophia David, Silvia Argimon, David M. Aanensen, Antonella Volta, Matteo Bisi, Sante Mazzacane, Elisabetta Caselli   +11 more
doaj   +1 more source

Weekly Influenza Surveillance Report Week 43 2003 [PDF]

, 2003
GP consultations rates for influenza-like illness increased during week 43 in Ireland. Influenza activity levels are higher than previously recorded for this time of year (the influenza surveillance scheme began in October 2000).
National Disease Surveillance Centre (NDSC), National Virus Reference Laboratory (NVRL), Irish College of General Practitioners (ICGP)   +2 more
core  

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Genomic insights into the spread and evolution of insecticide resistance variants in Anopheles gambiae s.l. from Burkina Faso

Scientific Reports
The intensive use of insecticide-based control tools has led to the rapid evolution of resistant phenotypes in malaria vector populations. Understanding the evolutionary processes underlying these resistances is essential to inform the development and ...
Mahamadi Kientega, Honorine Kaboré, Grégoire Sawadogo, Tin-Yu J. Hui, Nouhoun Traoré, Abdoul-Azize A. Millogo, Hamidou Maiga, Alistair Miles, Chris S. Clarkson, Abdoulaye Diabaté   +9 more
doaj   +1 more source

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source

AMR Surveillance in Africa: Are We There Yet?

International Journal of Infectious Diseases
Delineating the burden of antimicrobial resistance (AMR), detecting outbreaks due to multidrug resistant-bacteria and monitoring AMR trends for the early warning of emerging/escalating AMR in humans, animals, plants and the environment requires high ...
Prof Sabiha Essack, Sabiha Y. Essack
doaj   +1 more source

Weekly Influenza Surveillance Report Week 40 2002

, 2002
Welcome to the first influenza surveillance report of the 2002/2003 influenza season. This is the third year of influenza surveillance using computerised sentinel general practices in Ireland. The National Disease Surveillance Centre (NDSC) is working in
National Disease Surveillance Centre (NDSC), National Virus Reference Laboratory (NVRL), Irish College of General Practitioners (ICGP)   +2 more
core  

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Surveillance Hegemony

, 2015
The National Security Agency activity disclosed by Edward Snowden plugs into a larger information ecology made possible by U.S. surveillance hegemony. While the revelations of the NSA’s international spying ambitions have astonished, there is more to U.S.
Keiber, Jason
core   +1 more source