Results 61 to 70 of about 150,001 (296)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Epidemiological Genomics of Klebsiella pneumoniae isolates from hospitals across Colombia

npj Antimicrobials and Resistance
Klebsiella pneumoniae is one of the most important nosocomial pathogens worldwide. In Colombia, K. pneumoniae has been identified as the second most frequent microbial etiologic agent of healthcare-associated infections.
Victor A. Medina, Angela S. García-Vega, Fernando Rodríguez, Enmanuel S. Triviño-García, Jaime A. Robledo, Aura L. Leal, Julián C. Galvis, Luis F. Reyes, Genomic Epidemiology of Antimicrobial Resistance Consortium (GEAR), Iruka N. Okeke, Natacha Couto, Emmanuelle A. Kumaran, Georgina Lewis-Woodhouse, Silvia Argimon, Stefany A. Arevalo, Anthony P. Underwood, Xavier Fargetton, David M. Aanensen, Maria P. Donado-Godoy   +18 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Determining Gaps in Publicly Shared SARS-CoV-2 Genomic Surveillance Data by Analysis of Global Submissions

Emerging Infectious Diseases, 2022
Viral genomic surveillance has been a critical source of information during the COVID-19 pandemic, but publicly available data can be sparse, concentrated in wealthy countries, and often made public weeks or months after collection.
Elizabeth C. Ohlsen, Anthony W. Hawksworth, Kimberly Wong, Sarah Anne J. Guagliardo, James A. Fuller, Michelle L. Sloan, Kevin O’Laughlin   +6 more
doaj   +1 more source

Global genomic surveillance of monkeypox virus

Nature Medicine
Abstract Monkeypox virus (MPXV) is endemic in Western and Central Africa and, in May 2022, a clade IIb lineage (B.1) caused a global outbreak outside Africa, resulting in its detection in 117 countries/territories. To understand the global phylogenetics of MPXV, we carried out the first analysis of all available MPXV sequences ...
James R. Otieno, Christopher Ruis, Anyebe B. Onoja, Krutika Kuppalli, Ana Hoxha, Andreas Nitsche, Annika Brinkmann, Janine Michel, Placide Mbala-Kingebeni, Daniel Mukadi-Bamuleka, Muntasir Mohammed Osman, Hanadi Hussein, Muhammad Ali Raja, Richard Fotsing, Belinda L. Herring, Mory Keita, Jairo Mendez Rico, Lionel Gresh, Amal Barakat, Victoria Katawera, Karen Nahapetyan, Dhamari Naidoo, R. Andres Floto, Jane Cunningham, Maria D. Van Kerkhove, Rosamund F. Lewis, Lorenzo Subissi   +26 more
openaire   +3 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Genomic surveillance and evolution of Getah virus

Virus Evolution
Abstract Getah virus (GETV), a member of the Alphaviruses, has spread widely and is expanding its host range worldwide, posing a serious threat to public health safety and the farming industry. However, genetic monitoring of GETV is inadequate, and its evolution and transmission remain unclear.
Jiaqi Shen, Shaogui Liu, Shiqiang Liu, Shiyi Shen, Mingkai Lei, Qian Xu, Wentao Li, Qigai He, Xiaojuan Xu, Xuwang Cai   +9 more
openaire   +2 more sources

Genomic Surveillance of Rabies Virus in Georgian Canines

Viruses, 2023
Rabies is a fatal zoonosis that is considered a re-emerging infectious disease. Although rabies remains endemic in canines throughout much of the world, vaccination programs have essentially eliminated dog rabies in the Americas and much of Europe. However, despite the goal of eliminating dog rabies in the European Union by 2020, sporadic cases of dog ...
Celeste Huaman, Adrian C. Paskey, Caitlyn Clouse, Austin Feasley, Madeline Rader, Gregory K. Rice, Andrea E. Luquette, Maren C. Fitzpatrick, Hannah M. Drumm, Lianying Yan, Regina Z. Cer, Marina Donduashvili, Tamar Buchukuri, Anna Nanava, Christine E. Hulseberg, Michael A. Washington, Eric D. Laing, Francisco Malagon, Christopher C. Broder, Kimberly A. Bishop-Lilly, Brian C. Schaefer   +20 more
openaire   +3 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source