Results 51 to 60 of about 149,760 (296)

Emergence of Plasmodium falciparum pfdhps A581G mutation in Southern Senegal under Seasonal Malaria Chemoprevention pressure, 2020-2023

Communications Medicine
Background: Malaria prevention in Senegal includes the use of Seasonal Malaria Chemoprevention with sulfadoxine-pyrimethamine plus amodiaquine. Prolonged use of sulfadoxine-pyrimethamine, however, can select for mutations in the Plasmodium falciparum ...
Mamadou Alpha Diallo, Abdoulaye Tine, Djiby Sow, Aita Sene, Amy Gaye, Yaye D. Ndiaye, Jules Gomis, Baba Dieye, Awa B. Deme, Mamadou S. Yade, Bassirou Ngom, Mamane N. Garba, Ibrahima M. Ndiaye, Khadim Diongue, Aida Sadikh Badiane, Mame Cheikh Seck, Mouhamadou Ndiaye, Daouda Ndiaye   +17 more
doaj   +1 more source

Population genomics and antimicrobial resistance dynamics of Escherichia coli in wastewater and river environments

Communications Biology, 2021
Jose F. Delgado-Blas et al. report a genomic analysis of two antimicrobial-resistant E. coli populations from wastewater and river water. They find that bacteria from wastewater are more resistant to antibiotics and rely on a diverse set of plasmids for ...
Jose F. Delgado-Blas, Cristina M. Ovejero, Sophia David, Natalia Montero, William Calero-Caceres, M. Pilar Garcillan-Barcia, Fernando de la Cruz, Maite Muniesa, David M. Aanensen, Bruno Gonzalez-Zorn   +9 more
doaj   +1 more source

Prospects for genomic surveillance for selection in schistosome parasites

Frontiers in Epidemiology, 2022
Schistosomiasis is a neglected tropical disease caused by multiple parasitic Schistosoma species, and which impacts over 200 million people globally, mainly in low- and middle-income countries. Genomic surveillance to detect evidence for natural selection in schistosome populations represents an emerging and promising approach to identify and interpret
Nikolakis, Zachary L., Adams, Richard H., Wade, Kristen J., Lund, Andrea J., Carlton, Elizabeth J., Castoe, Todd A., Pollock, David D.   +6 more
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Public health surveillance of multidrug-resistant clones of Neisseria gonorrhoeae in Europe: a genomic survey

, 2018
Euro-GASP study group: INSA - Maria José BorregoFree PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010626/Background: Traditional methods for molecular epidemiology of Neisseria gonorrhoeae are suboptimal.
Yeats, Corin A, Spiteri, Gianfranco, Borrego, MJ, Crowley, B, Euro-GASP study group, Abad, R, Cole, Michelle J., Borrego, Maria José, Cole, Michelle J, Aanensen, David M, Aanensen, David M., Harris, Simon R., Unemo, M, Group,, Euro-Gasp Study, Tripodo, Francesco, Abad, Raquel, Sánchez-Busó, L, Aanensen, DM, Tripodo, F, Abudahab, K, Harris, Simon R, Borrego, María-José, Crowley, Brendan, Golparian, D, Golparian, Daniel, Spiteri, G, Jacobsson, S, Stefanelli, P, Stefanelli, Paola, Abudahab, Khalil, Cole, MJ, Goater, Richard, Bercot, Beatrice, Harris, SR, Euro-Gasp Study Group,, Sánchez-Busó, Leonor, Yeats, Corin A., Unemo, Magnus, Bercot, B, Jacobsson, Susanne, Goater, R, Yeats, CA   +41 more
core   +1 more source

The evolution, molecular epidemiology and genomic sampling of emerging viruses

, 2023
Emerging viruses represent a challenging threat to global health. Increasing human travel and global connectivity, changing climate patterns and incremental contact rates between human and animal populations contribute to the likelihood of emerging viral
Gutierrez Granja, Bernardo Miguel
core   +1 more source

Epidemiological Genomics of Klebsiella pneumoniae isolates from hospitals across Colombia

npj Antimicrobials and Resistance
Klebsiella pneumoniae is one of the most important nosocomial pathogens worldwide. In Colombia, K. pneumoniae has been identified as the second most frequent microbial etiologic agent of healthcare-associated infections.
Victor A. Medina, Angela S. García-Vega, Fernando Rodríguez, Enmanuel S. Triviño-García, Jaime A. Robledo, Aura L. Leal, Julián C. Galvis, Luis F. Reyes, Genomic Epidemiology of Antimicrobial Resistance Consortium (GEAR), Iruka N. Okeke, Natacha Couto, Emmanuelle A. Kumaran, Georgina Lewis-Woodhouse, Silvia Argimon, Stefany A. Arevalo, Anthony P. Underwood, Xavier Fargetton, David M. Aanensen, Maria P. Donado-Godoy   +18 more
doaj   +1 more source

Determining Gaps in Publicly Shared SARS-CoV-2 Genomic Surveillance Data by Analysis of Global Submissions

Emerging Infectious Diseases, 2022
Viral genomic surveillance has been a critical source of information during the COVID-19 pandemic, but publicly available data can be sparse, concentrated in wealthy countries, and often made public weeks or months after collection.
Elizabeth C. Ohlsen, Anthony W. Hawksworth, Kimberly Wong, Sarah Anne J. Guagliardo, James A. Fuller, Michelle L. Sloan, Kevin O’Laughlin   +6 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Global genomic surveillance of monkeypox virus

Nature Medicine
Abstract Monkeypox virus (MPXV) is endemic in Western and Central Africa and, in May 2022, a clade IIb lineage (B.1) caused a global outbreak outside Africa, resulting in its detection in 117 countries/territories. To understand the global phylogenetics of MPXV, we carried out the first analysis of all available MPXV sequences ...
James R. Otieno, Christopher Ruis, Anyebe B. Onoja, Krutika Kuppalli, Ana Hoxha, Andreas Nitsche, Annika Brinkmann, Janine Michel, Placide Mbala-Kingebeni, Daniel Mukadi-Bamuleka, Muntasir Mohammed Osman, Hanadi Hussein, Muhammad Ali Raja, Richard Fotsing, Belinda L. Herring, Mory Keita, Jairo Mendez Rico, Lionel Gresh, Amal Barakat, Victoria Katawera, Karen Nahapetyan, Dhamari Naidoo, R. Andres Floto, Jane Cunningham, Maria D. Van Kerkhove, Rosamund F. Lewis, Lorenzo Subissi   +26 more
openaire   +3 more sources