Results 31 to 40 of about 1,200,488 (250)

RDT performance through high-throughput bead-based antigen detection during malaria school survey in Senegal

Frontiers in Parasitology
BackgroundRapid Diagnostic Tests (RDTs) remain the frontline tool for malaria diagnosis, but their performance in detecting low-density infections is variable and poorly characterized at the population level.ObjectiveThis study aimed to evaluate the ...
Mamadou Alpha Diallo, Ibrahima M. Ndiaye, Djiby Sow, Mame Cheikh Seck, Khadim Diongue, Mariama Touré, Katerine E. Battle, Bassirou Ngom, Mouhamad Sy, Amy Gaye, Yaye Dié Ndiaye, Mamane Nassirou Garba, Aida Sadikh Badiane, Aita Sene, Medoune Ndiop, Jules François Gomis, Sarah K. Volkman, Doudou Sene, Bronwyn L. MacInnis, Ibrahima Diallo, Mouhamadou Ndiaye, Dyann F. Wirth, Daouda Ndiaye   +22 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The 'named person': surveillance and the wellbeing of children and young people in Scotland. [PDF]

, 2015
The Scottish Parliament’s ‘Children and Young People’ Bill has extended statutory responsibilities for the welfare of children to include their well-being.
Stoddart, Eric
core   +1 more source

Emergence of Plasmodium falciparum pfdhps A581G mutation in Southern Senegal under Seasonal Malaria Chemoprevention pressure, 2020-2023

Communications Medicine
Background: Malaria prevention in Senegal includes the use of Seasonal Malaria Chemoprevention with sulfadoxine-pyrimethamine plus amodiaquine. Prolonged use of sulfadoxine-pyrimethamine, however, can select for mutations in the Plasmodium falciparum ...
Mamadou Alpha Diallo, Abdoulaye Tine, Djiby Sow, Aita Sene, Amy Gaye, Yaye D. Ndiaye, Jules Gomis, Baba Dieye, Awa B. Deme, Mamadou S. Yade, Bassirou Ngom, Mamane N. Garba, Ibrahima M. Ndiaye, Khadim Diongue, Aida Sadikh Badiane, Mame Cheikh Seck, Mouhamadou Ndiaye, Daouda Ndiaye   +17 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Epidemiological Genomics of Klebsiella pneumoniae isolates from hospitals across Colombia

npj Antimicrobials and Resistance
Klebsiella pneumoniae is one of the most important nosocomial pathogens worldwide. In Colombia, K. pneumoniae has been identified as the second most frequent microbial etiologic agent of healthcare-associated infections.
Victor A. Medina, Angela S. García-Vega, Fernando Rodríguez, Enmanuel S. Triviño-García, Jaime A. Robledo, Aura L. Leal, Julián C. Galvis, Luis F. Reyes, Genomic Epidemiology of Antimicrobial Resistance Consortium (GEAR), Iruka N. Okeke, Natacha Couto, Emmanuelle A. Kumaran, Georgina Lewis-Woodhouse, Silvia Argimon, Stefany A. Arevalo, Anthony P. Underwood, Xavier Fargetton, David M. Aanensen, Maria P. Donado-Godoy   +18 more
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Determining Gaps in Publicly Shared SARS-CoV-2 Genomic Surveillance Data by Analysis of Global Submissions

Emerging Infectious Diseases, 2022
Viral genomic surveillance has been a critical source of information during the COVID-19 pandemic, but publicly available data can be sparse, concentrated in wealthy countries, and often made public weeks or months after collection.
Elizabeth C. Ohlsen, Anthony W. Hawksworth, Kimberly Wong, Sarah Anne J. Guagliardo, James A. Fuller, Michelle L. Sloan, Kevin O’Laughlin   +6 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Are schools panoptic? [PDF]

, 2010
Schools are often understood by social researchers as panoptic spaces, where power is exercised through constant surveillance and monitoring. In this paper, I use Foucault’s notorious account of the Panopticon as a point of departure for a detailed ...
Gallagher, M.
core