Results 131 to 140 of about 150,001 (296)

Pipeline for SARS-CoV-2 genomic surveillance [PDF]

In the United States, CDC tracks emerging variants through genomic surveillance using a multilayered approach.Publication date from document properties.tracking-sars-cov-3-variants-infographic-9-2 ...

core  

Genomic Surveillance of Foodborne Pathogens: Advances and Obstacles

Journal of Public Health Management & Practice
Context: The genomic surveillance of foodborne pathogens in the United States has grown exponentially in the past decade, grounded in a powerful combination of novel sequencing technologies, bioinformatic approaches, data-sharing networks, and metadata harmonization efforts.
Gensheimer, Kathleen, Allard, Marc W., Timme, Ruth E., Brown, Eric, Hintz, Leslie, Pettengill, Jamie, Strain, Errol, Tallent, Sandra M., Vélez, Lili F., King, Ewa, Shea, Sharon L.   +10 more
openaire   +2 more sources

Risk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model

Advanced Science, EarlyView.
Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen   +16 more
wiley   +1 more source

National investment case development for pathogen genomics

Cell Genomics
Summary: Sustaining and expanding genomic surveillance capacity requires broader investment in genomics that target both novel and pandemic pathogens. Currently, there is no standardized methodology to evaluate the cost and benefit of a multi-pathogen ...
Yoong Khean Khoo, Suci Wulandari, Marya Getchell, La Moe, Shurendar Selva Kumar, Elyssa Jiawen Liu, Yimei Sun, Junxiong Pang, Swapnil Mishra, Hannah Clapham, Ben Marais, Vitali Sintchenko, Ruklanthi de Alwis, David Hipgrave, Paul Michael Pronyk   +14 more
doaj   +1 more source

CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano, Allen C. Luo, Paul Taufalele, Jenna A. Dombroski, Ehsan Aalaei, Schyler J. Rowland, Melissa S. Cantú, Alexandria T. Carter, Samantha V. Knoblauch, Cynthia A. Reinhart‐King, Michael R. King   +10 more
wiley   +1 more source

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

Genomic surveillance of Methicillin Resistant Staphylococcus aureus in Saudi Arabia. [PDF]

Methicillin-resistant Staphylococcus aureus (MRSA) surveillance in regions with mass gatherings presents unique challenges for public health systems. Saudi Arabia, hosting millions of pilgrims annually, provides a distinctive setting for studying how ...
H. Abutarboush, Mohammed, A Alshehri, Mohammad, Albarrag, Ahmed M, Hoehndorf, Robert, Kulmanov, Maxat, Kameli, Nader, B. Al-Fageeh, Mohammed, A Suliman, Bandar, G Aljohani, Areej, F Felemban, Rakan, I Hobani, Haya, Ahmad Bahitham, Wesam, Al Johani, Sameera M., Ahmed Darraj, Majid, BALKHY, Hanan H., J. Alyamani, Essam, Alarawi, Mohammed, Kafkas, Senay, Alhazmi, Abdulaziz H, S Abdoh, Mohammed, Alosaimi, Lamia, A.Shajri, Amjad, A. Huraysi, Abdulaziz, A. Hemeg, Hassan, Kaaki, Mai, Altammami, Musaad, M. Alnafjan, Basel, Al-Zahrani, Ibrahim A, Rahama, Badreldin, Alswaji, Abdulrahman A., Hala, Sharif, Aldakhil, Hind, Abdelhakim, Marwa, Hashem, Anwar M, Hong, Peiying, Mawsil Alkuraythi, Dalal, ALZAYER, Maha, M. Alhoshani, Fahad, A Alhazmi, Wafaa, Sufyani, O. O., Alamer, Edrous, A. Bakr, Abrar, Alalwan, Bassam, Gojobori, Takashi, Almaabadi, Amani, Alghoribi, Majed F, A. Bawazeer, Reema, Radley, Robert Paul, Algaissi, Abdullah, A. Alolayan, Mohammed, Abujamel, Turki S, M. Somily, Ali, Yahya Zakri, Samer, S. Bahwerth, Fayez, Ahmad Fallatah, Omniya, Kameli, Bandar, A. Alquait, Azzam, A. Aldakeel, Sumayh, Miyazaki, Satoru   +58 more
core   +1 more source

Integrating Genomic Data into Public Health Surveillance for Multidrug-Resistant Organisms, Washington, USA

Emerging Infectious Diseases
Mitigating antimicrobial resistance (AMR) is a public health priority to preserve antimicrobial treatment options. The Washington State Department of Health in Washington, USA, piloted a process to leverage longitudinal genomic surveillance on the basis
Laura Marcela Torres, Jared Johnson, Audrey Valentine, Audrey Brezak, Emily C. Schneider, Marisa D’Angeli, Jennifer Morgan, Claire Brostrom-Smith, Chi N. Hua, Michael Tran, Darren Lucas, Joenice Gonzalez De Leon, Drew MacKellar, Philip Dykema, Kelly J. Kauber, Allison Black   +15 more
doaj   +1 more source

Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3

Advanced Science, EarlyView.
This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death.
Dan Zhao, Lingling Zhang, Yue Wen, Lianghui Cheng, Sidan Tian, Fanling Meng, Liang Luo   +6 more
wiley   +1 more source