Results 141 to 150 of about 150,001 (296)

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source

Post-genomic surveillance for communicable disease control [PDF]

Genomic surveillance is now at the forefront of translational research due to recent significant advances in genomics and informatics, increasing demands for rapid detection of outbreaks and transformational impact of culture-independent testing on ...

core  

Pathogen Genomic Surveillance and Bioinformatics Training and Capacity Development Across Africa

International Journal of Infectious Diseases
Introduction: The recent emergence and re-emergence of infectious diseases across Africa have emphasised the critical need for vigorous pathogen genomic surveillance systems on the continent.
Ms Siddiqah George, Ms Kirsty Lee Garson, Mr Tony Yiquan Li, Mr Perceval Maturure, Professor Nicola Mulder   +4 more
doaj   +1 more source

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

One health genomic surveillance in the post-COVID-19 era: opportunities and challenges [PDF]

During the COVID-19 pandemic, genomic surveillance of SARS-CoV-2 by using next-generation sequencing (NGS) becomes an integral component for studying the viral evolution and identification of new variants so that mitigation strategies can be carried out ...
Ang, Geik Yong, Zakaria, Zunita, Mat Isa, Nurulfiza, Yee, Yu Choo   +3 more
core  

Genomic epidemiology of SARS-CoV-2 in Bolivia, 2020–2024

Microbiology Spectrum
The COVID-19 pandemic has severely impacted Bolivia due to its high social vulnerability and limited healthcare resources. In response to the limited local capacity for genomic surveillance during the pandemic, we characterized the genetic diversity and ...
Esdenka Pérez-Cascales, Francesca Caballero, Anne Martínez-Ventura, Brenda Ayzanoa, Mauricio Prado-Zapata, Eliana Baldiviezo-Soliz, Paula Carballo-Jiménez, Freddy Tinajeros-Guzmán, Diego Cuicapuza, Pablo Tsukayama   +9 more
doaj   +1 more source

Genomics in Epidemiology and Disease Surveillance: An Exploratory Analysis

Life
Genomics has revolutionized epidemiology and disease surveillance by providing powerful tools for identifying, tracking, and analyzing pathogens at the molecular level. This exploratory analysis examines the integration of genomic with traditional epidemiological approaches, highlighting the role of whole-genome sequencing as a key method for pathogen ...
Shraddha Tiwari, Thakur Dhakal, Baek-Jun Kim, Gab Sue Jang, Yeonsu Oh   +4 more
openaire   +2 more sources

Innovations in Gastric Cancer Surgery During Early Minimally Invasive Era and Future Perspectives

Annals of Gastroenterological Surgery, EarlyView.
With continuing revelations in tumor biology and the emergence of artificial intelligence, new horizons for surgical innovation are opening. At the center of this transformative journey stands the innovative surgeon, driven by passion, guided by data, and steadfast in the commitment to patient safety and quality of life.
Reut El‐On, Young‐Woo Kim
wiley   +1 more source

A response playbook for early detection and population surveillance of new SARS-CoV-2 variants in a regional public health laboratory

BMC Public Health
Background Timely genomic surveillance is required to inform public health responses to new SARS-CoV-2 variants. However, the processes involved in local genomic surveillance introduce inherent time constraints.
Hannah J. Barbian, Alyse Kittner, Richard Teran, Sofiya Bobrovska, Xueting Qiu, Kayla English, Stefan J. Green, Isaac Ghinai, Massimo Pacilli, Mary K. Hayden   +9 more
doaj   +1 more source

Prognostic Impact of Metastasis Timing in Metastatic Gastrointestinal Stromal Tumors: A Multicenter Retrospective Cohort Study

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Gastrointestinal stromal tumors (GISTs) commonly metastasize to the liver and peritoneum. Metastases may be detected synchronously at the time of initial diagnosis or develop metachronously after curative‐intent resection. Nonetheless, the prognostic significance of metastasis timing in advanced GIST remains unclear.
Kunihiko Kawai, Tsuyoshi Takahashi, Ryugo Teranishi, Shinsuke Sato, Yukinori Kurokawa, Toshirou Nishida, Seiichi Hirota, Jyunya Fujita, Yuichiro Doki, Toshimasa Tsujinaka   +9 more
wiley   +1 more source