Results 161 to 170 of about 149,760 (296)

Genomic surveillance of Methicillin Resistant Staphylococcus aureus in Saudi Arabia.

Methicillin-resistant Staphylococcus aureus (MRSA) surveillance in regions with mass gatherings presents unique challenges for public health systems. Saudi Arabia, hosting millions of pilgrims annually, provides a distinctive setting for studying how ...
H. Abutarboush, Mohammed, A Alshehri, Mohammad, Albarrag, Ahmed M, Hoehndorf, Robert, Kulmanov, Maxat, Kameli, Nader, B. Al-Fageeh, Mohammed, A Suliman, Bandar, G Aljohani, Areej, F Felemban, Rakan, I Hobani, Haya, Ahmad Bahitham, Wesam, Al Johani, Sameera M., Ahmed Darraj, Majid, BALKHY, Hanan H., J. Alyamani, Essam, Alarawi, Mohammed, Kafkas, Senay, Alhazmi, Abdulaziz H, S Abdoh, Mohammed, Alosaimi, Lamia, A.Shajri, Amjad, A. Huraysi, Abdulaziz, A. Hemeg, Hassan, Kaaki, Mai, Altammami, Musaad, M. Alnafjan, Basel, Al-Zahrani, Ibrahim A, Rahama, Badreldin, Alswaji, Abdulrahman A., Hala, Sharif, Aldakhil, Hind, Abdelhakim, Marwa, Hashem, Anwar M, Hong, Peiying, Mawsil Alkuraythi, Dalal, ALZAYER, Maha, M. Alhoshani, Fahad, A Alhazmi, Wafaa, Sufyani, O. O., Alamer, Edrous, A. Bakr, Abrar, Alalwan, Bassam, Gojobori, Takashi, Almaabadi, Amani, Alghoribi, Majed F, A. Bawazeer, Reema, Radley, Robert Paul, Algaissi, Abdullah, A. Alolayan, Mohammed, Abujamel, Turki S, M. Somily, Ali, Yahya Zakri, Samer, S. Bahwerth, Fayez, Ahmad Fallatah, Omniya, Kameli, Bandar, A. Alquait, Azzam, A. Aldakeel, Sumayh, Miyazaki, Satoru   +58 more
core   +1 more source

Utilizing virus genomic surveillance to predict vaccine effectiveness. [PDF]

PLoS Comput Biol
Kwon J, Li K, Warren JL, Pandya S, Hahn AM, Yale SARS-CoV-2 Genomic Surveillance Initiative, Pitzer VE, Weinberger DM, Grubaugh ND.   +8 more
europepmc   +1 more source

Stem cell–based therapies for type 1 diabetes: Progress in differentiation, clinical translation, and immune protection

Animal Models and Experimental Medicine, EarlyView.
Directed differentiation of pluripotent stem cells into functional pancreatic β cells have emerged as a promising strategy for the radical treatment of type 1 diabetes, with preclinical and early clinical evidence demonstrating reversal of hyperglycemia and insulin independence.
Zifan Li, Yu Kang, Yuyu Niu
wiley   +1 more source

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Genomic surveillance of post-immunization pneumococcal carriage in Ghana. [PDF]

Microb Genom
Akwetey SA, Kwenda S, Addy HPK, Nyarko EF, Fiam E, Quansah E, Donkor IE, Acheampong DO, Kwakye-Nuako G, Abdullah MR, Hammerschmidt S, Ismail A, Mills RO.   +12 more
europepmc   +1 more source

Development of a loop‐mediated isothermal amplification‐lateral flow dipstick (LAMP‐LFD) assay and on‐site rapid detection evaluation for Rodentibacter heylii and Rodentibacter pneumotropicus

Animal Models and Experimental Medicine, EarlyView.
This study established a closed‐tube LAMP‐LFD assay for detecting Rodentibacter heylii and Rodentibacter pneumotropicus. The method exhibited high sensitivity (detection limits of 10−5 ng/μL for R. heylii and 10−4 ng/μL for R. pneumotropicus), high specificity, reliable performance with clinical samples, and effective validation in experimental ...
Huiqiong Yan, Sisi Chen, Yuhan Gan, Jing Xing, Yufang Feng, Xin Wen, Jie Fang, Jiangtao Du, Shasang Zhou, Honggang Guo, Xiaoyin Jin, Zhiyuan Wang, Junhao Tao, Lingqun Lu, Qingming Kong, Huazhong Ying, Wei Han, Fangwei Dai   +17 more
wiley   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Post-genomic surveillance for communicable disease control

Genomic surveillance is now at the forefront of translational research due to recent significant advances in genomics and informatics, increasing demands for rapid detection of outbreaks and transformational impact of culture-independent testing on ...

core  

Genomic Surveillance of Lassa Virus through In-Country Sequencing, Guinea. [PDF]

Emerg Infect Dis
Camara J, Annibaldis G, Klaps J, Ifono K, Koundouno FR, Sidibé Y, Ryter S, Conde M, Millimono SL, Hinrichs M, Hinzmann J, Petersen NP, Le M, Renevey A, Emua EE, Lemey P, Dellicour S, Günther S, Magassouba N, Duraffour S, Kafetzopoulou LE, Boumbaly S.   +21 more
europepmc   +1 more source

Co‐Infection of Brucella canis and Brucella melitensis in a Domestic Dog With Zoonotic Transmission to Human, China

Animal Research and One Health, EarlyView.
Source attribution figure for human and dogs Brucella canis infections. ABSTRACT We report a rare occurrence of genetic material from both Brucella canis and B. melitensis detected in a domesticated dog from Jiangsu Province, China. The detection was confirmed through serological assays, quantitative PCR (qPCR), metagenomic and genomic sequencing ...
Shengxin Ge, Jian Xu, Qingchun Shen, Jiabo Ding, Xiaowen Yang   +4 more
wiley   +1 more source