Results 231 to 240 of about 150,001 (296)

Global solidarity in genomic surveillance improves early detection of acute respiratory virus threats. [PDF]

Nat Commun
de Jong SPJ, Nichols BE, de Ruijter A, Parker E, Mitesser V, Happi C, de Jong MD, Han AX, Russell CA.   +8 more
europepmc   +1 more source

Gene signatures characterizing driver mutations in lung squamous carcinoma are predictive of the progression of pre‐cancer lesions

International Journal of Cancer, EarlyView.
What's New? Lung squamous cell carcinoma (LUSC) is more aggressive than lung adenocarcinoma, and is most often diagnosed at an advanced stage. Here, the authors evaluated gene expression data from LUSC tumors and came up with gene signatures for 34 genetic abnormalities whose expression changes throughout different precancerous stages. Several of these
Yupei Lin, Venugopalareddy Mekala, Jianrong Li, Xiang Wang, Muhammad Aminu, Jia Wu, Jianjun Zhang, Robert Taylor Ripley, Christopher I. Amos, Chao Cheng   +9 more
wiley   +1 more source

Correction to "The Development of Global Genomic Surveillance of Respiratory Syncytial Virus: Insights From 25 Project Countries, 2019-2023". [PDF]

Influenza Other Respir Viruses
europepmc   +1 more source

Genomic surveillance inequities in emerging infectious diseases: Why fragile settings like Somalia are critical to global health security. [PDF]

New Microbes New Infect
Hassan AA, Abdullahi YB, Sudi LA, Mohamed MD, Ibrahim IO.   +4 more
europepmc   +1 more source

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

Persistence of legacy antimalarial resistance markers in The Gambia from a malaria genomic surveillance study

Diop MF, Amambua-Ngwa BN, Demba MA, Bah M, Njie BK, Cham F, Mendy M, Bojang F, Ndiath MO, Correa A, Ünlü ES, Mains A, Mohammed NI, D’Alessandro U, Simpson VJ, Rajatileka S, Samateh W, Gibba B, Oriero EC, Amambua-Ngwa A.   +19 more
europepmc   +1 more source

Tuberculosis in the Americas: a worsening crisis amid genomic surveillance gaps. [PDF]

Lancet Reg Health Am
Salvato RS, Walter KS, Dos Santos-Filho ET, Perdigão J, Kritski AL.   +4 more
europepmc   +1 more source

Living at genetic risk: The patient experience of Lynch syndrome

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome is a germline cancer predisposition syndrome caused by a variant in one of four genes. Lynch syndrome places individuals at significantly higher risk for a range of cancers, especially colorectal and endometrial. Depending on which gene is affected, the risk of ovarian, gastric, small bowel, pancreatic, biliary urothelial, brain,
Nicola Reents, Georgina Hoffmann, Kelly Kohut   +2 more
wiley   +1 more source

Nationwide genomic surveillance of carbapenem- and colistin-resistant Klebsiella pneumoniae bloodstream isolates in Thailand (2020-2024). [PDF]

Sci Rep
Krobanan K, Kamjumphol W, Leethongdee P, Unahalekhaka A, Sripichai O, Cheunban N, Thadtapong N, Kurehong C, Okada PA, Premsuriya J.   +9 more
europepmc   +1 more source

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source