Results 161 to 170 of about 179,984 (263)

Novel Mutations in KCNJ10 Gene Associated With SeSAME Syndrome: Rare Disorder With Possible Common Mutation. [PDF]

Mol Genet Genomic Med
Shakeri S, Mohammadi S, Sadeghipour F, Masoudi M, Entezam M.   +4 more
europepmc   +1 more source

Molecular Engineering Mediated Interfacial Assembly as an Artificial Extracellular Matrix Remolds Bacteria With Enhanced Abiotic Resilience

Advanced Science, EarlyView.
A biomimetic artificial extracellular matrix is assembled directly on Pseudomonas fluorescens by co‐assembling amyloid‐like lysozyme and alginate at the cell surface. This conformal nanocoating acts as both a hydration buffer and a physiological priming layer, markedly enhancing desiccation tolerance, seed adhesion, storage stability, and biocontrol ...
Yuanyuan Wang, Zili Jia, Yang Li, Qitao Wang, Shuai Hou, Lei Liu   +5 more
wiley   +1 more source

Evaluation and Selection of Stable Reference Genes for qRT-PCR Analysis in Different Tissues of <i>Mugilogobius chulae</i> Under Pollutant Exposure. [PDF]

Animals (Basel)
Dong Z, Gao J, Li X, Chen Z, Li J, Liao J, Zhang Y, Wang Z, Guo Y, Zhang N.   +9 more
europepmc   +1 more source

All‐Flex Plasma Patch for In Vivo Delivery of Reactive Species

Advanced Science, EarlyView.
A fully flexible plasma patch enables stable, conformal treatment on complex biological surfaces and enhances transdermal delivery of reactive species. This platform achieves significant tumor suppression in vivo and reveals coordinated regulation of calcium signaling, metabolism, and programmed cell death, providing a promising strategy for safe and ...
Luxiang Zhao, Abulaihaiti Tuergong, Hanshu Yang, Shuang Xue, An Yan, Mingzhen Wang, Weilong Song, Wenzhe Si, Ruixue Wang   +8 more
wiley   +1 more source

Genetic and Epigenetic Mechanisms Underlying Reversible Adaptive Responses in Fungi. [PDF]

J Fungi (Basel)
Dan L, Liu S, Qiang Z, Ye X, Zhang J.
europepmc   +1 more source

When Biology Meets Medicine: A Perspective on Foundation Models

Advanced Intelligent Discovery, EarlyView.
Artificial intelligence, and foundation models in particular, are transforming life sciences and medicine. This perspective reviews biological and medical foundation models across scales, highlighting key challenges in data availability, model evaluation, and architectural design.
Kunying Niu, Yuxing Wang, Limin Zou, Jing Huang   +3 more
wiley   +1 more source

Rare genetic diseases associated with G-quadruplex-induced replication stress. [PDF]

Commun Biol
Herr LM, Mukhopadhyay S, Anderson OM, Couch TH, Jones CM, Brosh RM, Rossi M.   +6 more
europepmc   +1 more source

Therapy for Myhre Syndrome: Goals, Misconceptions, and Current Agents

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre Syndrome (MYHRS, MIM #139210) is a rare, multisystem connective tissue disorder caused by recurrent heterozygous gain‐of‐function pathogenic variants in the SMAD4 gene, a key player in TGF‐β signaling and a regulator of extracellular matrix homeostasis.
Alessandro De Falco, Alfonso Manuel D'Alessio, Nicola Brunetti‐Pierri   +2 more
wiley   +1 more source

Thermostable Bioluminescent Intercalating Dyes for Real‐Time, Integrated Nucleic Acid Amplification and Detection

Angewandte Chemie, EarlyView.
We present a bioluminescent diagnostic platform that integrates DNA amplification and detection in a single step. The engineering of thermostable luciferase‐intercalating dye conjugates and controlled release of caged luciferin substrates enable real‐time, detection of attomolar concentrations of viral DNA within 30 min.
Yosta de Stigter, Harmen J. van der Veer, Sterre de Lignie, Robbert J. de Haas, Renko de Vries, Joost P. H. Schoeber, Anne J. M. Loonen, Adriaan J. C. van den Brule, Maarten Merkx   +8 more
wiley   +2 more sources

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source