Results 181 to 190 of about 95,572 (232)

Comparative Sequence Analysis of the Envelope Gene of Kyasanur Forest Disease Virus Vaccine Strain With Currently Circulating Field Strains. [PDF]

Adv Virol
Kaje K, Marinaik CB, Gomes AR, Rizwan A, Hiremath J, Rathnamma D, Isloor S, Patil SS, Archana M.   +8 more
europepmc   +1 more source

Integrating Reinforcement Learning With Explainable Artificial Intelligence for Real‐Time Clinical Decision Support in Dynamic Healthcare Environments

Advanced Intelligent Systems, EarlyView.
A hybrid Reinforcement Learning–Explainable AI framework integrates SHAP and LIME explanations directly into a Deep Q‐Network inference loop for real‐time ICU decision support. Trained on 18 142 mechanically ventilated stays from the eICU database, the system attains 93.0% decision accuracy, 20% fewer errors than RL alone, and a 91% clinician trust ...
Jannatul Ferdaus Disha, MD Faiaz Zaman Dehan, Kazi Md. Tanvir Anzum   +2 more
wiley   +1 more source

Spatial Coupling of Viral RNA Translation and Replication in Zika Infection. [PDF]

ACS Omega
Zheng G, Li Y, He X, Tao Y, Zhang J, Zhang L, Chen M, Cai P, Cho WC, Zheng Y, Zhang X.   +10 more
europepmc   +1 more source

Intermolecular Carbon–Carbon Naphthalene Coupling Involves a Radical Mechanism Driven by Cytochrome P450 in Alternaria alternata

Angewandte Chemie, EarlyView.
1,8‐DHN is an important intermediate to form complex aromatic ring systems. Phenol‐coupling reactions are important for the dimerization of two molecules. Here, we show that a fungal cytochrome P450 enzyme catalyzes specific C─C bonds. ABSTRACT Dihydroxynaphthalene (DHN) derivatives are precursors of biologically important molecules, including melanin ...
Jia Gao, Leyao Chen, Karin Steffen, Henrik Schweder, Birgit Schreckenberger, Shu‐Ming Li, Ben Auxier, Antonis Rokas, Reinhard Fischer   +8 more
wiley   +1 more source

Benchmarking Denoising Strategies and Nucleic Acid Templates for ITS2 Amplicon Sequencing of Gut Mycobiome. [PDF]

FASEB J
Dai T, Dai Y, Bai J, Li W, Chen P.
europepmc   +1 more source

dsRADAR: Imaging and Detecting Cellular dsRNA by Repurposing RNA‐Binding Proteins

Angewandte Chemie, EarlyView.
Double‐stranded RNA (dsRNA) plays an important role in the innate immune system, but can be misregulated in disease, leading to inflammation. Despite the importance of this motif, methods for detecting dsRNA remain limited. This work shows that ADAR3 can be repurposed to provide improved detection of dsRNA, which is demonstrated in the context of viral
Weina Cheng, Tyson D. Todd, Alexandria L. Quillin, Harshad Ingle, Angela M. Halstead, Megan T. Baldridge, José B. Sáenz, Jennifer M. Heemstra   +7 more
wiley   +1 more source

The G-force in the genome: Unknowns on the functional flairs of DNA G-quadruplexes. [PDF]

PLoS Biol
Gallina I, Richter SN.
europepmc   +1 more source

Reverse Genetics of Orthoflaviviruses: Strategies for Constructing Functional or Infectious cDNA. [PDF]

J Med Virol
Lee YM.
europepmc   +1 more source

A Dual-Plasmid CRISPR/Cas9-Based Genome Editing System for Efficient Gene Knockout and Large DNA Integration in <i>Cronobacter malonaticus</i>. [PDF]

Pathogens
Yan S, Zhang J, Han Y, Jia J, Yun G, Liu D, Ma Y, Liu Z, Wang Y, Wang H.   +9 more
europepmc   +1 more source