ASSESSMENT OF LEAD STRESS USING GENOME TEMPLATE STABILITY IN Hordeum vulgare
Egyptian Journal of Genetics and Cytology, 2016 Assement of genotoxins-induced DNA damage at molecular level is important in eco-genotoxicology. In this research, ISSR and SRAP were used to detect DNA damage in barley (Hordeum vulgare L.) seeding exposed to toxic ascending Pb at concentration of 50,100, and 150 mg/l for 15 days.
HALA MAHFOUZ, WALAA RAYAN
openaire +1 more source
Risks from low dose/dose rate radiation: what an understanding of DNA damage response mechanisms can tell us [PDF]
, 2009 The DNA damage response (DDR) mechanisms represent a vital line of defense against exogenous and endogenous DNA damage to enhance two distinct outcomes, survival and the maintenance of genomic stability. The latter is critical for cancer avoidance.
Jeggo, Peggy A.
core +2 more sources
Transcription-Replication Collisions—A Series of Unfortunate Events
Biomolecules, 2021 Transcription-replication interactions occur when DNA replication encounters genomic regions undergoing transcription. Both replication and transcription are essential for life and use the same DNA template making conflicts unavoidable.
Commodore St Germain +2 more
doaj +1 more source
Transcription as a Threat to Genome Integrity [PDF]
, 2016 Genomes undergo different types of sporadic alterations, including DNA damage, point mutations, and genome rearrangements, that constitute the basis for evolution.
Aguilera López, Andrés +1 more
core +1 more source
Aceh Journal of Animal Science, 2022 Fish health and the aquatic ecosystem are strongly interwoven and interrelated. The aquatic ecosystem receives a range of anthropogenic chemicals which have toxicological or lethal health effects on the aquatic animals.
Charity E. Ejikeme +2 more
doaj +1 more source
Towards a typing strategy for Arcobacter species isolated from humans and animals and assessment of the in vitro genomic stability [PDF]
, 2014 Arcobacter species have a widespread distribution with a broad range of animal hosts and environmental reservoirs, and are increasingly associated with human illness.
Baré, Julie +3 more
core +2 more sources
The prebiotic evolutionary advantage of transferring genetic information from RNA to DNA. [PDF]
, 2011 In the early 'RNA world' stage of life, RNA stored genetic information and catalyzed chemical reactions. However, the RNA world eventually gave rise to the DNA-RNA-protein world, and this transition included the 'genetic takeover' of information storage ...
Chen, Irene A +4 more
core +4 more sources
Accurate protein stability predictions from homology models
Computational and Structural Biotechnology Journal, 2023 Calculating changes in protein stability (ΔΔG) has been shown to be central for predicting the consequences of single amino acid substitutions in protein engineering as well as interpretation of genomic variants for disease risk.
Audrone Valanciute +5 more
doaj +1 more source
Is PCNA unloading the central function of the Elg1/ATAD5 replication factor C-like complex? [PDF]
, 2013 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.Peer ...
Donaldson, Anne D +2 more
core +1 more source
Impact of template backbone heterogeneity on RNA polymerase II transcription. [PDF]
, 2014 Variations in the sugar component (ribose or deoxyribose) and the nature of the phosphodiester linkage (3'-5' or 2'-5' orientation) have been a challenge for genetic information transfer from the very beginning of evolution.
Chong, Jenny +5 more
core +1 more source