Results 41 to 50 of about 95,572 (232)

The Impact of Zinc Oxide Nanoparticles on Cytotoxicity, Genotoxicity, and miRNA Expression in Barley (Hordeum vulgare L.) Seedlings

The Scientific World Journal, 2020
Zinc oxide nanoparticles are one of the most commonly engineered nanomaterials and necessarily enter the environment because of the large quantities produced and their widespread application. Understanding the impacts of nanoparticles on plant growth and
Ilona Plaksenkova, Inese Kokina, Anastasija Petrova, Marija Jermaļonoka, Vjačeslavs Gerbreders, Marina Krasovska   +5 more
doaj   +1 more source

Determination of cytogenetic and epigenetic effects of manganese and copper on Zea mays L.

ISPEC Journal of Agricultural Sciences, 2021
Heavy metal accumulation and its possible effects are prominent problem for not only human health but also for the environment and plant systems due to that heavy metals are non-biodegradable.
Filiz AYGÜN ERTÜRK, Serap SUNAR, Güleray AĞAR   +2 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Heavy Metals Pollution and its Genotoxicity Assessment through the Green Marine Ulva lactuca (Chlorophyceae) Algae in the Lattakia-Coastline, Syria [PDF]

Journal of Stress Physiology & Biochemistry, 2020
The current study was conducted to investigate pollution level in Lattakia-coastline, Syria using Ulva lactuca (Chlorophyta) algae as bioindicator for sea water pollution based on Zn, Pb, Cu and Cd concentration using Atomic Absorption Spectrometry (AAS)
Basel Saleh
doaj  

Application of Nucleic Acid Reference Material for Rapid Detection of Cronobacter sakazakii (Cronobacter spp.) in Flammulina velutipes

Journal of Food Quality, 2020
Cronobacter sakazakii (C. sakazakii) widely exists in the environment and is a common foodborne pathogenic microorganism. It can cause meningitis, bacteremia, and necrotizing enterocolitis in infants and elderly people with low immunity.
Huandie Yang, Danyang Guo, Leilei Chen, Alexander Suvorov, Qingxin Zhou, Junhua Wang, Xiaofeng Gao, Jinyu Yang, Xiangyan Chen   +8 more
doaj   +1 more source

Mycobacterium Time-Series Genome Analysis Identifies AAC2′ as a Potential Drug Target with Naloxone Showing Potential Bait Drug Synergism

Molecules, 2022
The World Health Organization has put drug resistance in tuberculosis on its list of significant threats, with a critical emphasis on resolving the genetic differences in Mycobacterium tuberculosis. This provides an opportunity for a better understanding
Vidya Niranjan, Akshay Uttarkar, Keerthana Murali, Swarna Niranjan, Jayalatha Gopal, Jitendra Kumar   +5 more
doaj   +1 more source

Genomic Template Stability assessed in almond trees of cv. ‘Vairo’ treated with biostimulants and boron-based fertilizers

, 2022
Almond is highly produced in the NE of Portugal, where late frosts during flowering, low precipitation, and high temperature in summer affect productivity and quality. In addition to late-flowering cultivars, plant biostimulants (PBs) and boron-based fertilizers have been used to improve cell division, vegetative growth, photoassimilates rate, and ...
Carvalho, Ana, Esteves, Ana, Roque, J., Rodrigues, M.A., Correia, Carlos M., Lima-Brito, José   +5 more
openaire   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source