Results 111 to 120 of about 927,032 (316)
Genomics and drug discovery [PDF]
, 2002 Genomics represents a new tool in drug discovery. Microbial genomics have been at the forefront of a new era of whole cell molecular biology because genomic data provides a quantum leap in available genetic data.
Hazell, Stuart L.
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Aquatic Plant Genomics: Advances, Applications, and Prospects [PDF]
, 2017 Genomics is a discipline in genetics that studies the genome composition of organisms and the precise structure of genes and their expression and regulation. Genomics research has resolved many problems where other biological methods have failed.
Hu, Shiqi +7 more
core +1 more source
From individuals to communities: How genomics is transforming biodiversity conservation [PDF]
Genetics and Molecular BiologyGenomics has rapidly become one of the most transformative scientific approaches in modern conservation biology. As biodiversity faces increasing threats from climate change, habitat degradation, invasive species, and other human impacts, the use of ...
Larissa S. Arantes +6 more
doaj +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
GENOMICS IN ASIA: A CLASH OF BIOETHICAL INTERESTS?
, 2004 Contents -- Acknowledgements -- Introduction -- Ch. 1. Genomics in Asia: cultural values and bioethical practices / Margaret Sleeboom -- Pt. I. Religious perspectives -- Ch. 2. Ethical issues: an Islamic perspective / Anwar Nasim -- Ch. 3.
Sleeboom, Margaret, ed.
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A summary report of the 8th annual International Workshop on Environmental Genomics (IWEG)
Centre for Environmental Genomics Applications, CEGA
core +1 more source
Frontiers in Genetics, 2019 Genomic medicine applications have the potential to considerably improve health care in developing countries in the coming years. However, if developing countries do not improve their capacity for research and development (R&D) in the field, they ...
Martin Hetu +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source