Results 111 to 120 of about 1,430,518 (311)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

GetGenome: Overcoming inequalities in access to genomics technology.

PLoS Biology
Although genomics has become integral to life science research, inequitable access to genomics technology remains prevalent. GetGenome, a non-profit organization, aims to overcome this by providing equitable access to genomics technology and training.
James Canham, Joe Win, GetGenome Network, Sophien Kamoun   +3 more
doaj   +1 more source

Ten Years of Landscape Genomics: Challenges and Opportunities

Frontiers in Plant Science, 2017
Landscape genomics is a relatively new discipline that aims to reveal the relationship between adaptive genetic imprints in genomes and environmental heterogeneity among natural populations. Although the interest in landscape genomics has increased since
Yong Li, Xue-Xia Zhang, Run-Li Mao, Jie Yang, Cai-Yun Miao, Zhuo Li, Ying-Xiong Qiu   +6 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Psychiatric Genomics: An Update and an Agenda

bioRxiv, 2017
The Psychiatric Genomics Consortium (PGC) is the largest consortium in the history of psychiatry. In the past decade, this global effort has delivered a rapidly increasing flow of new knowledge about the fundamental basis of common psychiatric disorders,
P. Sullivan, A. Agrawal, C. Bulik, O. Andreassen, A. Børglum, G. Breen, S. Cichon, H. Edenberg, S. Faraone, J. Gelernter, C. Mathews, C. Nievergelt, J. Smoller, M. O’Donovan   +13 more
semanticscholar   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Responsible genomes: How can we foster responsible innovation in synthetic genomics?

Journal of Responsible Innovation
Reflections on the responsible development of synthetic genomics have contributed to shaping Responsible Research and Innovation (RRI) as an area of inquiry.
Paolo Corsico, Philip Shapira
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Surges and insights from the genomics of insect pests

Genomics Communications
Genomics has revolutionized our understanding of agricultural insects by revealing the genetic basis of their adaptation, pesticide resistance, and ecological success, while also driving the development of sustainable pest management innovations ...
Alexander Yesaya, Lei Zhang, Yan Peng, Yutao Xiao   +3 more
doaj   +1 more source

Understanding Ethical, Legal and Societal Issues (ELSIs) in Human Biobanking and Genomics for Research and Healthcare in Zimbabwe: The Genomics Inheritance Law Ethics and Society (GILES) initiative [version 2; peer review: 2 approved]

AAS Open Research, 2019
Biobanks and human genomics applications are key for understanding health, disease and heredity in Africa and globally. Growing interest in these technologies calls for strengthening relevant legal, ethical and policy systems to address knowledge ...
Alice Matimba, Andrew Chimatira, Oppah Kuguyo, James January, Zivayi Mupambireyi, Bazondlile Marimbe-Dube, Vasco Chikwasha, Zibusiso Nyati-Jokomo, Shamiso Muteti, Pedzisayi Mangezvo, Abigail Kangwende, Alfred Chingono, Midion Chidzonga, Jonathan Gandari, James Hakim, Kusum Nathoo, Christopher Samkange, Walter Mangezi, Sandra Lee, Lovemore Gwanzura, Mildred Cho, Paul Ndebele   +21 more
doaj   +1 more source