Results 121 to 130 of about 844,050 (314)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
GetGenome: Overcoming inequalities in access to genomics technology.
PLoS BiologyAlthough genomics has become integral to life science research, inequitable access to genomics technology remains prevalent. GetGenome, a non-profit organization, aims to overcome this by providing equitable access to genomics technology and training.
James Canham +3 more
doaj +1 more source
Responsible genomes: How can we foster responsible innovation in synthetic genomics?
Journal of Responsible InnovationReflections on the responsible development of synthetic genomics have contributed to shaping Responsible Research and Innovation (RRI) as an area of inquiry.
Paolo Corsico, Philip Shapira
doaj +1 more source
Ten Years of Landscape Genomics: Challenges and Opportunities
Frontiers in Plant Science, 2017 Landscape genomics is a relatively new discipline that aims to reveal the relationship between adaptive genetic imprints in genomes and environmental heterogeneity among natural populations. Although the interest in landscape genomics has increased since
Yong Li +6 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Surges and insights from the genomics of insect pests
Genomics CommunicationsGenomics has revolutionized our understanding of agricultural insects by revealing the genetic basis of their adaptation, pesticide resistance, and ecological success, while also driving the development of sustainable pest management innovations ...
Alexander Yesaya +3 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Functional Genomics for Plant Breeding 3.0 [PDF]
Functional genomics, as a scientific discipline, has significantly transformed the landscape of plant breeding in recent years [...
José Manuel Cruz-Rubio, Fatemeh Maghuly
core +1 more source
Genomics and Public Health: Development of Web-based Training
Preventing Chronic Disease, 2005 In 2001, the Centers for Disease Control and Prevention funded three Centers for Genomics and Public Health to develop training tools for increasing genomic awareness.
Janice V. Bach, MS +5 more
doaj
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source