Review of State Comprehensive Cancer Control Plans for Genomics Content
Preventing Chronic Disease, 2005 Introduction The goals of this study were to determine U.S. states with Comprehensive Cancer Control plans that include genomics in some capacity and to review successes with and barriers to implementation of genomics-related cancer control initiatives.
Robert C. Millikan, DVM, PhD +3 more
doaj
Health Fetishism Among The Nacirema: A Fugue On Jenny Reardon’s The Postgenomic Condition: Ethics, Justice, and Knowledge After The Genome (Chicago University Press, 2017) And Isabelle Stengers’ Another Science Is Possible: A Manifesto For Slow Science (Polity Press, 2018) [PDF]
, 2018 Personalized medicine has become a goal of genomics and of health policy makers. This article reviews two recent books that are highly critical of this approach, finding their arguments very thoughtful and important. According to Stengers, biology’s rush
Gilbert, Scott F.
core +2 more sources
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Frontiers in Genetics, 2019 Genomic medicine applications have the potential to considerably improve health care in developing countries in the coming years. However, if developing countries do not improve their capacity for research and development (R&D) in the field, they ...
Martin Hetu +2 more
doaj +1 more source
Gastric cancer and genomics: review of literature [PDF]
, 2022 Takumi Onoyama +2 more
openalex +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Phandango: an interactive viewer for bacterial population genomics
bioRxiv, 2017 Summary Fully exploiting the wealth of data in current bacterial population genomics datasets requires synthesising and integrating different types of analysis across millions of base pairs in hundreds or thousands of isolates.
J. Hadfield +5 more
semanticscholar +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
GetGenome: Overcoming inequalities in access to genomics technology.
PLoS BiologyAlthough genomics has become integral to life science research, inequitable access to genomics technology remains prevalent. GetGenome, a non-profit organization, aims to overcome this by providing equitable access to genomics technology and training.
James Canham +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source