Results 141 to 150 of about 2,130,247 (378)

Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status [PDF]

, 2019
Paul Lyons, James E. Peters, Federico Alberici, James Liley, Richard Coulson, William J. Astle, Chiara Baldini, Francesco Bonatti, María C. Cid, Heather Elding, Giacomo Emmi, Jörg T. Epplen, Loı̈c Guillevin, David Jayne, Tao Jiang, Iva Gunnarsson, Peter Lamprecht, Stephen Leslie, Mark A. Little, Davide Martorana, Frank Moosig, Thomas Neumann, Sophie Ohlsson, Stefanie Quickert, Giuseppe A. Ramirez, Barbara Rewerska, Georg Schett, Renato Alberto Sinico, Wojciech Szczeklik, Vladimı́r Tesař, Damjan Vukcevic, Mohammed Akil, Jonathan Barratt, Neil Basu, Adam S. Butterworth, Ian N Bruce, Michael Clarkson, Niall Conlon, Bhaskar Dasgupta, Timothy Doulton, Georgina Espígol‐Frigolé, Oliver Floßmann, Tianlu Li, Jolanta Gąsior, Gina Gregorini, Giuseppe Guida, José Hernández‐Rodríguez, Zdenka Hrušková, Amy W. Hudson, Ann Knight, Peter Lanyon, Raashid Luqmani, Malgorzata Magliano, Angelo A. Manfredi, Christopher Marguerie, Federica Maritati, Chiara Marvisi, Neil McHugh, Eamonn Molloy, Allan Motyer, Chetan Mukhtyar, Leonid Padyukov, Alberto Pesci, Sergio Prieto‐González, Marc Ramentol-Sintas, Petra Reis, Dario Roccatello, Patrizia Rovere‐Querini, Carlo Salvarani, Francesca Santarsia, Roser Solans‐Laqué, Nicole Soranzo, Jo Taylor, Julie Wessels, Jochen Zwerina, Benjamin Terrier, Richard A. Watts, Augusto Vaglio, Julia U. Holle, Chris Wallace, Kenneth G. C. Smith   +80 more
openalex   +1 more source

Visualizing and interpreting cancer genomics data via the Xena platform

Nature Biotechnology, 2020
M. Goldman, Brian Craft, Mim Hastie, Kristupas Repečka, Fran McDade, Akhil Kamath, Ayan Banerjee, Yunhai Luo, Dave Rogers, Angela N. Brooks, Jingchun Zhu, D. Haussler   +11 more
semanticscholar   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Genomic resolution of an aggressive, widespread, diverse and expanding meningococcal serogroup B, C and W lineage [PDF]

, 2015
Jay Lucidarme, Dorothea M. C. Hill, Holly B. Bratcher, Steve Gray, Mignon du Plessis, Raymond S. W. Tsang, Julio A. Vázquez, Muhamed‐Kheir Taha, Mehmet Ceyhan, Adriana Efron, Maria Cecília Gorla, Jamie Findlow, Keith A. Jolley, Martin Maiden, Ray Borrow   +14 more
openalex   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Genomics and Public Health: Development of Web-based Training

Preventing Chronic Disease, 2005
In 2001, the Centers for Disease Control and Prevention funded three Centers for Genomics and Public Health to develop training tools for increasing genomic awareness.
Janice V. Bach, MS, Aaron Goldenberg, MA, MPH, Toby Citrin, JD, Sarah F. Raup, MPH, Jennifer Bodzin, MPH, Sharon L.R. Kardia, PhD   +5 more
doaj  

Assessing genomics confidence and learning needs in Australian nurses and midwives: an educational program evaluation

Frontiers in Genetics
Introduction: The mainstreaming of genomics across healthcare specialties necessitates that all nurses and midwives have a high literacy in genomics.Methods: We aimed to design, develop, implement and evaluate a genomics education workshop for nurses and
Kim E. Alexander, Kim E. Alexander, Melanie Rolfe, Melanie Rolfe, Michael T. Gabbett   +4 more
doaj   +1 more source

Big Data: Astronomical or Genomical?

PLoS Biology, 2015
Genomics is a Big Data science and is going to get much bigger, very soon, but it is not known whether the needs of genomics will exceed other Big Data domains.
Zachary D Stephens, Skylar Y Lee, Faraz Faghri, Roy H Campbell, Chengxiang Zhai, Miles J Efron, Ravishankar Iyer, Michael C Schatz, Saurabh Sinha, Gene E Robinson   +9 more
doaj   +1 more source