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Assessment of Estrogenic and Genotoxic Activity in Wastewater Using Planar Bioassays. [PDF]
ToxicsWindisch M, Rieser V, Kittinger C.
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Enhancing multi-task in vivo toxicity prediction via integrated knowledge transfer of chemical knowledge and in vitro toxicity information. [PDF]
J CheminformPark M, Shin Y, Kim H, Nam H.
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Mini-review: Human N-acetyltransferase genetic polymorphisms in susceptibility to aromatic amine and alkylaniline genotoxicity. [PDF]
J Pharmacol Exp TherHabil MR, Hein DW.
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Plain Language Summary of the Re-assessment of the risks to public health related to the genotoxicity of styrene present in plastic food contact materials. [PDF]
EFSA Jeuropepmc +1 more source
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Quantifying genotoxicity and non-genotoxicity
Mutation Research/Genetic Toxicology, 1988Since the ability to induce genotoxicity is often equated with the potential for initiating the carcinogenic process, a method for quantitating genotoxicity would provide a useful measure for this potential. It is demonstrated herein that CPBS, the Carcinogenicity Prediction and Battery Selection method, provides a useful quantitative measure of ...
H S, Rosenkranz, F K, Ennever
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2021
The assessment of the potential of a new drug to cause genotoxicity is a prerequisite for its progression to clinical development. This chapter gives a concise overview of the major aspects relating to genotoxicity, which are relevant in small molecule drug discovery. Testing schemes and assays recommended by regulatory guidelines are outlined.
Stephan Kirchner, Patrick Schnider
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The assessment of the potential of a new drug to cause genotoxicity is a prerequisite for its progression to clinical development. This chapter gives a concise overview of the major aspects relating to genotoxicity, which are relevant in small molecule drug discovery. Testing schemes and assays recommended by regulatory guidelines are outlined.
Stephan Kirchner, Patrick Schnider
openaire +1 more source
Current Drug Metabolism, 2018
With the rapid development of nanoparticles in drug delivery system, a lot of interest in the genotoxicity evaluation of nanocarriers has emerged currently. Here our emphasis was placed on the summary of studies on standard genotoxicity assays.We performed a PubMed/MEDLINE search for all publications in the English language related to assessment of ...
Ting, Luo +4 more
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With the rapid development of nanoparticles in drug delivery system, a lot of interest in the genotoxicity evaluation of nanocarriers has emerged currently. Here our emphasis was placed on the summary of studies on standard genotoxicity assays.We performed a PubMed/MEDLINE search for all publications in the English language related to assessment of ...
Ting, Luo +4 more
openaire +2 more sources