Results 301 to 310 of about 125,041 (360)

Surface expression of antitoxin on engineered bacteria neutralizes genotoxic colibactin in the gut. [PDF]

Nat Microbiol
Yang S, Wang Z, Fang C, Yang M, Khawaled S, Bonanno S, Joshi NS, Wei Y, Zhang K, Márquez-Pellegrin V, Guan M, Zhang S, Bader AC, Ye N, Haley AE, Dame MK, Spence JR, He X, Fox JG, Yilmaz ÖH, Shah YM, Romee R, Li J.   +22 more
europepmc   +1 more source

<i>In vivo</i> genotoxicity of Chios mastic gum in rodent bone marrow micronucleus test. [PDF]

Toxicol Rep
Psarou EC, Termentzi A, Kyriakopoulou K, Anastasiadou P, Meidanis M, Fokialakis N, Machera K.   +6 more
europepmc   +1 more source

An improved lentivirus vector for safer transgene integration and protein transduction [PDF]

Schenkwein, Diana
core  

Genotoxic Impurities

, 2011
openaire   +4 more sources

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Quantifying genotoxicity and non-genotoxicity

Mutation Research/Genetic Toxicology, 1988
Since the ability to induce genotoxicity is often equated with the potential for initiating the carcinogenic process, a method for quantitating genotoxicity would provide a useful measure for this potential. It is demonstrated herein that CPBS, the Carcinogenicity Prediction and Battery Selection method, provides a useful quantitative measure of ...
H S, Rosenkranz, F K, Ennever
openaire   +2 more sources

Genotoxicity

2021
The assessment of the potential of a new drug to cause genotoxicity is a prerequisite for its progression to clinical development. This chapter gives a concise overview of the major aspects relating to genotoxicity, which are relevant in small molecule drug discovery. Testing schemes and assays recommended by regulatory guidelines are outlined.
Stephan Kirchner, Patrick Schnider
openaire   +1 more source

Genotoxicity of Nanocarriers

Current Drug Metabolism, 2018
With the rapid development of nanoparticles in drug delivery system, a lot of interest in the genotoxicity evaluation of nanocarriers has emerged currently. Here our emphasis was placed on the summary of studies on standard genotoxicity assays.We performed a PubMed/MEDLINE search for all publications in the English language related to assessment of ...
Ting, Luo, Long, Gao, Xiaowei, Chen, Ke, Xu, Meng, Niu   +4 more
openaire   +2 more sources

Genotoxicity of Streptozotocin

Mutation Research/Reviews in Mutation Research, 2002
Streptozotocin (Streptozocin, STZ, CAS No. 18883-66-4) is a monofunctional nitrosourea derivative isolated from Streptomyces achromogenes. It has broad spectrum antibiotic activity and antineoplastic properties and is often used to induce diabetes mellitus in experimental animals through its toxic effects on pancreatic beta cells.
Alejandro D, Bolzán, Martha S, Bianchi
openaire   +2 more sources