Results 171 to 180 of about 302,540 (297)

Context‐Dependent Role of GDF15: GDF15+ Tumor‐Associated Macrophages Suppress OSCC Progression by Enhancing Phagocytosis

Advanced Science, EarlyView.
This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou, Zhihang Zhou, Houyu Ju, Chaoyang Guo, Fangxing Zhu, Yiyi Zhang, Xu Chen, Tongchao Zhao, Laiping Zhong, Jingzhou Hu   +9 more
wiley   +1 more source

Genotype-by-environment interaction with high-dimensional environmental data: an example in pigs. [PDF]

Genet Sel Evol
Bussiman F, Lourenco D, Hidalgo J, Chen CY, Holl J, Misztal I, Vitezica ZG.   +6 more
europepmc   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Genotype-by-environment interaction influencing sensory attributes and biochemical components of peanuts from China. [PDF]

Front Plant Sci
Tang Y, Cao S, Zhang C, Hu W, Zhou H, Wang M, Zhu L, Chen J, Zhang J, Zhang J.   +9 more
europepmc   +1 more source

Direct Extracellular Matrix Modulation Attenuates Intestinal Fibrosis via a Fibronectin‐Targeted Approach

Advanced Science, EarlyView.
Fibronectin regulates the extracellular matrix (ECM)–myofibroblast cycle through three key steps: (1) its secretion and assembly by myofibroblasts (inhibited by pUR4); (2) collagen deposition along its scaffold (inhibited by R1R2); and (3) integrin α5β1‐mediated mechanotransduction (inhibited by ATN161).
Wenlong Ma, Siyu Yang, Tengkai Wang, Di Zhang, Hewei Wu, Shichen Fu, Xiaohan Wan, Lixiang Li, Xiuli Zuo, Yanqing Li, Jiaoyang Lu   +10 more
wiley   +1 more source

Genotype by environment interaction and yield stability analysis of durum wheat (Triticum turgidum var. durum) varieties using AMMI and GGE biplot analysis in Amahara Region, Northwest Ethiopia. [PDF]

PLoS One
Eskezia A, Ayenew A, Azene Y, Aytenew M, Nakachew K.   +4 more
europepmc   +1 more source

Analysing and modelling genotype-by-environment interaction

, 2008
In sunflower crop, the actual seed yield stagnation results from a singular compensation between genetic progress (+1. 3% potential yield/year) and degradation of cultural environments and crop management. Independently of this progress, Genotype by environment (GxE) interactions lead to highly variable cultivar performance regarding pedo-climatic and ...
openaire   +1 more source

Spatial Transcriptomics of TMJ Reveals a Remodeling Fibroblast‐Immune Microenvironment Driving Arthritis Pain

Advanced Science, EarlyView.
Spatial transcriptomics reveals a remodeled fibroblast‐immune microenvironment in the temporomandibular joint (TMJ) during arthritis. By combining seqFISH with genetic mouse models, this study uncovers TMJ spatial cell atalas, macrophage‐fibroblast crosstalk, and cytokine signaling pathways driving TMJ inflammation and pain.
Ziying Lin, Supawadee Jariyasakulroj, Yang Shu, Jingyi Chen, Qing Chang, Pao‐Fen Ko, Yuyueyang Qiu, Feixiang Chen, David Ahn, Zhen Zhao, Jian‐Fu Chen   +10 more
wiley   +1 more source

A framework for simulating genotype-by-environment interaction using multiplicative models. [PDF]

Theor Appl Genet
Bančič J, Gorjanc G, Tolhurst DJ.
europepmc   +2 more sources

Genotype-by-Environment Interaction in Red Tilapia (<i>Oreochromis</i> spp.): Implications for Genetic Parameters and Trait Performance. [PDF]

Genes (Basel)
Phuc TH, Khoa PD, Dang NT, Huong TTM, Lien HTB, Tham VTH, Duy NH, Nguyen NH.   +7 more
europepmc   +1 more source