Results 41 to 50 of about 130,079 (257)

Evaluating Genotype × Environment Interactions of Yield Traits and Adaptability in Rice Cultivars Grown under Temperate, Subtropical and Tropical Environments

Agriculture, 2021
Rice yield is a complex trait that is strongly affected by environment and genotype × environment interaction (GEI) effects. Consideration of GEI in diverse environments facilitates the accurate identification of optimal genotypes with high yield ...
Xing Huang, Su Jang, Backki Kim, Zhongze Piao, Edilberto Redona, Hee-Jong Koh   +5 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Multi-environments Evaluation of Zn and Fe Enhanced Bread Wheat Genotypes in Optimum Areas of Ethiopia

International Journal of Bio-Resource and Stress Management
A multi-location experiment was conducted during June, 2020–October, 2021 under rainfed condition at Kulumsa, Asasa, Adet, Holeta, and Sinana Research centers, Ethiopia to evaluate the genotype-by-environment interaction effect and grain yield stability
Alemu Dabi, Gadisa Alemu, Berhanu Sime, Ruth Duga, Negash Geleta, Abebe Delessa, Tafesse Solomon, Habtemariam Zegaye, Cherinet Kasahun, Dawit Asnake, Bayisa Asefa, Abebe Getamesay, Demeke Zewudu, Ayele Badebo, Bekele Abeyo, Tilahun Bayisa, Endashaw Girma, Velu Govindan, Zerihun Tadesse   +18 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Environmental stratification based on a 28 x 28 diallel of open-pollinated maize varieties

Crop Breeding and Applied Biotechnology, 2008
The objective of this study was to assess the representativeness of the test environments used by the maize breeding program of Embrapa in the first phase of genotype evaluation.
Cleso Antônio Patto Pacheco, Heyder Diniz Silva, Manoel Xavier dos Santos, Paulo Evaristo de Oliveira Guimarães, Sidney Netto Parentoni, Elto Eugênio Gomes e Gama, Carlos Alberto Scapim, Walter Fernandes Meirelles, Hélio Wilson Lemos de Carvalho, Pedro Abel Vieira Junior   +9 more
doaj  

Genotype by environment interaction and yield stability in sugarcane

Revista Facultad Nacional de Agronomía Medellín, 2017
Genotype by environment interaction (GEI) reduces the association between phenotype and genotype which result in relative ranking and stability differences of genotypes across environment.
Ramon Antonio Rea, Orlando De Sousa-Vieira, Alida Díaz Lucena, Miguel Ramón, Rosaura Briceño Cárdenas   +4 more
doaj   +1 more source

Grain yield stability analysis using parametric and nonparametric statistics in oat (Avena sativa L.) genotypes in Ethiopia

Grassland Research, 2023
Background The performance of oat genotypes differs across environments due to variations in biotic and abiotic factors. Thus, evaluation of oat genotypes across diverse environments is very important to identify superior and stable genotypes for yield ...
Gezahagn Kebede, Walelign Worku, Habte Jifar, Fekede Feyissa   +3 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source