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Genotype–phenotype mapping: genes as computer programs
The effects of genes on phenotype are mediated by processes that are typically unknown but whose determination is desirable. The conversion from gene to phenotype is not a simple function of individual genes, but involves the complex interactions of many genes; it is what is known as a nonlinear mapping problem.
Douglas B Kell
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Learning an evolvable genotype-phenotype mapping
We present AutoMap, a pair of methods for automatic generation of evolvable genotype-phenotype mappings. Both use an artificial neural network autoencoder trained on phenotypes harvested from fitness peaks as the basis for a genotype-phenotype mapping.
Moreno, Matthew Andres +2 more
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Emergence of Modularity in Genotype-Phenotype Mappings
A novel evolutionary method that allows us to study the emergence of modularity for genotype-phenotype mapping in the course of Darwinian evolution is described. The method is based on composite epigenotypes with two parts: a binary genotype; and a mapping of genes onto phenotype characters.
Vladimir Kvasnicka, Jiri Pospichal
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Investigation of the importance of the genotype–phenotype mapping in information retrieval
Future Generation Computer Systems, 2003An investigation of the role of the Genotype-Phenotype mapping (G-Pm) is presented for an evolutionary optimization task. A simple genetic algorithm plus a mapping creates a new Mapping Genetic Algorithm (MGA) that is used to optimize a Boolean decision tree for an information retrieval task, with the tree being created via a relatively complex mapping.
José Luis Fernández-Villacañas Martín +1 more
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Budding Yeast Strains and Genotype–Phenotype Mapping
A small number of well-studied laboratory strains of Saccharomyces cerevisiae, mostly derived from S288C, are used in yeast research. Although powerful, studies for understanding S288C do not always capture the phenotypic essence or the genetic complexity of S. cerevisiae biology. This is particularly problematic for multilocus phenotypes identified in
Gianni, Liti +2 more
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Inferring sparse structure in genotype-phenotype maps
GENETICS, 2022Abstract Correlation among multiple phenotypes across related individuals may reflect some pattern of shared genetic architecture: individual genetic loci affect multiple phenotypes (an effect known as pleiotropy), creating observable relationships between phenotypes.
Samantha Petti +2 more
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Biological Theory, 2006
The current implementation of the Neo-Darwinian model of evolution typically assumes that the set of possible phenotypes is organized into a highly symmetric and regular space. Most conveniently, a Euclidean vector space is used, representing phenotypic properties by real-valued variables.
Peter F. Stadler, Bärbel M. R. Stadler
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The current implementation of the Neo-Darwinian model of evolution typically assumes that the set of possible phenotypes is organized into a highly symmetric and regular space. Most conveniently, a Euclidean vector space is used, representing phenotypic properties by real-valued variables.
Peter F. Stadler, Bärbel M. R. Stadler
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Chapter 3 Genotype–Phenotype Mapping
International Review of Cell and Molecular Biology, 2009Joel Atallah, Ellen Larsen
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Genotype–phenotype mapping implications for genetic programming representation: Commentary on “On the mapping of genotype to phenotype in evolutionary algorithms” by Peter A. Whigham, Grant Dick, and James Maclaurin [PDF]
This comment refers to the article available at doi:10.1007/s10710-017-9288-x. Here we comment on the article “On the mapping of genotype to phenotype in evolutionary algorithms,” by Peter A. Whigham, Grant Dick, and James Maclaurin.
Aniko Ekart +2 more
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